Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Paul J. Cote"'
Autor:
Ricardo Ramirez, Li Li, William E. Delaney, Stephan Menne, Sarina Ma, Changsuek Yon, Don Kang, Jason Chamberlain, Christian Voitenleitner, William Rowe, Ruth Chu, Dhivya Ramakrishnan, Magdeleine Hung, Manasa Suresh, Divya Pattabiraman, Stephane Daffis, Paul J. Cote, Rex Santos, Bei Li, Simon P. Fletcher, Scott Balsitis, Sandra Spurlock, Mish Michael R, Jim Zheng, Richard L. Mackman
Publikováno v:
Hepatology (Baltimore, Md.)
Background and aims GS-9688 (selgantolimod) is an oral selective small molecule agonist of toll-like receptor 8 in clinical development for the treatment of chronic hepatitis B. In this study, we evaluated the antiviral efficacy of GS-9688 in woodchu
Autor:
Jason Chamberlain, Richard L. Mackman, William E. Delaney, Stephane Daffis, M. Suresh, Paul J. Cote, Simon P. Fletcher, Mish Michael R, Changsuek Yon, Dhivya Ramakrishnan, William Rowe, Stephan Menne, Jim Zheng, Rita Santos
Publikováno v:
Journal of Hepatology. 66:S692-S693
Autor:
Anand Mehta, Gomathinayagam Sinnathamby, Bud C. Tennant, Ramila Philip, Timothy M. Block, Paul J. Cote, Pamela A. Norton, Stephan Menne, Lucy Betesh
Publikováno v:
Hepatology. 52:1242-1250
In this report, the possibility of pharmacologically altering the hepatitis B virus (HBV) epitopes presented by major histocompatibility complex class I on infected cells is demonstrated. The HBV middle envelope glycoprotein (MHBs) maturation appears
Autor:
Bud C. Tennant, Stephan Menne, Paul J. Cote, Andrea L. George, Jeffery Fairman, Scott D. Butler, John L. Gerin
Publikováno v:
Journal of Medical Virology. 81:1760-1772
Complexes of cationic liposomes and non-coding DNA (CLDC) have shown promise as vaccine adjuvant. Using the woodchuck animal model of hepatitis B virus (HBV) infection, the immunogenic effects of CLDC were evaluated following vaccination with three d
Publikováno v:
Hepatology. 45:614-622
Resolution of hepatitis B virus (HBV) infection is characterized by coordinated humoral and cellular immune responses. Immunity is durable over decades, protecting the host from reinfection and potential activation of residual HBV. Woodchucks infecte
Autor:
Fabian Birzele, Miriam Triyatni, Linta M. Thampi, Jade Carter, Paul J. Cote, Dalal AlDeghaither, Erik Rasmussen, Erhard Kopetzki, Hans Bitter, Palanikumar Ravindran, Stefan Lorenz, Junming Yang, Daniel J. Chin, Roland Schmucki, Lore Gruenbaum, Stephan Menne, Marta G. Murreddu, David C. Swinney, Simon P. Fletcher
Publikováno v:
PLoS Pathogens, Vol 11, Iss 9, p e1005103 (2015)
PLoS Pathogens
PLoS Pathogens
Recombinant interferon-alpha (IFN-α) is an approved therapy for chronic hepatitis B (CHB), but the molecular basis of treatment response remains to be determined. The woodchuck model of chronic hepatitis B virus (HBV) infection displays many charact
Autor:
Paul J. Cote, Mark Johnson
Publikováno v:
Materials and Manufacturing Processes. 21:628-633
A comprehensive model of the cylindrical magnetron sputtering system is described. Microstructural features that affect the performance of the coating are modeled and compared to experimental data obtained from atomic force microscopy. Dynamic scalin
Publikováno v:
Surface and Coatings Technology. 200:5767-5777
The corrosion behaviour of α- and β-Ta coatings was compared to that of Cr coatings produced by cylindrical magnetron sputtering as well as electrodeposition. For Ta coatings, the corrosion process was dominated by dissolution of the steel substrat
Autor:
Paul J. Cote, Bud C. Tennant, Chung K. Chu, John L. Casey, Illia A. Toshkov, William E. Hornbuckle, John L. Gerin, Brent E. Korba
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:4396-4399
In a small controlled study, clevudine, a potent inhibitor of hepadnaviruses, including hepatitis B virus and woodchuck hepatitis virus, suppressed hepatitis delta virus (HDV) viremia in chronically infected woodchucks. Suppression was correlated wit
Autor:
Paul J. Cote, Shelly Xiong, Ilia A. Tochkov, Brent E. Korba, Scott D. Butler, Stephan Menne, William E. Delaney, Andrea L. George, John L. Gerin, Bud C. Tennant
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:2720-2728
Tenofovir disoproxil fumarate (TDF) is a nucleotide analogue approved for treatment of human immunodeficiency virus (HIV) infection. TDF also has been shown in vitro to inhibit replication of wild-type hepatitis B virus (HBV) and lamivudine-resistant