Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Paul J. Coleman"'
Autor:
Andres D. Ramirez, Anthony L. Gotter, Steven V. Fox, Pamela L. Tannenbaum, Lihang eYao, Spencer J. Tye, Terrence eMcDonald, Joseph eBrunner, Susan L. Garson, Duane R. Reiss, Scott D. Kuduk, Paul J. Coleman, Jason M. Uslaner, Robert eHodgson, Susan E. Browne, John J. Renger, Christopher J. Winrow
Publikováno v:
Frontiers in Neuroscience, Vol 7 (2013)
Dual orexin receptor antagonists (DORAs) are a potential treatment for insomnia that function by blocking both the orexin 1 and orexin 2 receptors. The objective of the current study was to further confirm the impact of therapeutic mechanisms targeti
Externí odkaz:
https://doaj.org/article/7a637e4e89e342579deeac811d80cf1d
Autor:
Mark E. Layton, Jeffrey C. Kern, Timothy J. Hartingh, William D. Shipe, Izzat Raheem, Monika Kandebo, Robert P. Hayes, Sarah Huszar, Donnie Eddins, Bennett Ma, Joy Fuerst, Gordon K. Wollenberg, Jing Li, Jeff Fritzen, Georgia B. McGaughey, Jason M. Uslaner, Sean M. Smith, Paul J. Coleman, Christopher D. Cox
Publikováno v:
Journal of Medicinal Chemistry. 66:1157-1171
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34d1b1b6ca3f79f9d512404321891d5
https://doi.org/10.1021/acs.jmedchem.2c01521
https://doi.org/10.1021/acs.jmedchem.2c01521
Autor:
Scott E. Wolkenberg, Richard J. O. Barnard, Steven N. Gallicchio, Michael A. Plotkin, Douglas C. Beshore, Christine Burlein, Robert W. Myers, M. Katharine Holloway, Daniel J. Klein, Vanessa L. Rada, Christopher D. Cox, David A. Powell, Daniel Krosky, Paul J. Coleman, Gregory C. Adam, Sangita B. Patel, Wei Lemaire
Publikováno v:
ACS Medicinal Chemistry Letters
A novel series of histone deacetylase (HDAC) inhibitors lacking a zinc-binding moiety has been developed and described herein. HDAC isozyme profiling and kinetic studies indicate that these inhibitors display a selectivity preference for HDACs 1, 2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d663d85c125a580cc2715339d0489294
http://europepmc.org/articles/PMC8040053
http://europepmc.org/articles/PMC8040053
Autor:
Jim J. Hagan, John J. Renger, Thomas S. Kilduff, Paul J. Coleman, Jerome M. Siegel, Jyrki P. Kukkonen, Christopher J. Winrow, Luis de Lecea, Daniel Hoyer, Roderick A. Porter, Anthony L. Gotter, Gregor J Sutcliffe, Neil Upton
Publikováno v:
IUPHAR BPS Guide Pharm CITE
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [42]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1196f26965e8dd135a136421a8771cb
https://doi.org/10.2218/gtopdb/f51/2021.3
https://doi.org/10.2218/gtopdb/f51/2021.3
Autor:
Jay A. Grobler, Abbas Walji, Paul J. Coleman, Min Xu, Timothy J. Hartingh, Natasa Pajkovic, John T. Sisko, David A. Powell, John M. Sanders, Michael D. Miller, Mark Embrey, Rada Vanessa L, Keith P. Moore, Daniel J. Klein, Nguyen Natalie, Izzat T. Raheem, Dubost David C, Guillaume Barbe, Louis-Charles Campeau, Daria J. Hazuda, John S. Wai, Thomas G. Steele, John D. Schreier, Jamie M. McCabe Dunn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2038-2046
HIV integrase strand transfer inhibitors (InSTIs) represent an important class of antiviral therapeutics with proven efficacy and excellent tolerability for the treatment of HIV infections. In 2007, Raltegravir became the first marketed strand transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3afda9a20f9b604f336f17e0d16627b
https://doi.org/10.1016/j.bmcl.2017.02.039
https://doi.org/10.1016/j.bmcl.2017.02.039
Autor:
Mark E. Layton, Eleftheria N. Finger, Edward C. Sherer, Amy Jo Koser, Aneta Jovanovska, Robert Gomez, Xiu Wang, Deping Wang, Xuanjia Peng, John Majercak, Melissa Egbertson, Paul J. Coleman, Rebecca M. Klein, Kristen L.G. Jones, Richard L. Kraus, Jixin Wang, Tracey Filzen, Mark O. Urban, Yuxing Li, Anthony J. Roecker, Matthew J. Cato, Ying-Hong Wang, Michelle K. Clements, Jacqueline Panigel, Leo A. Joyce, Vincent P. Santarelli, Irene Gregan, Christopher Daley, Haiyan Sun, Andrea K. Houghton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2087-2093
The voltage-gated sodium channel Nav1.7 is a genetically validated target for the treatment of pain with gain-of-function mutations in man eliciting a variety of painful disorders and loss-of-function mutations affording insensitivity to pain. Unfort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6460ec06d229cf43b30709ab80de83e3
https://doi.org/10.1016/j.bmcl.2017.03.085
https://doi.org/10.1016/j.bmcl.2017.03.085
Publikováno v:
Annual Review of Pharmacology and Toxicology. 57:509-533
Historically, pharmacological therapies have used mechanisms such as γ-aminobutyric acid A (GABAA) receptor potentiation to drive sleep through broad suppression of central nervous system activity. With the discovery of orexin signaling loss as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f03b823bb14ac4fe502377dc24ac029
https://doi.org/10.1146/annurev-pharmtox-010716-104837
https://doi.org/10.1146/annurev-pharmtox-010716-104837
Autor:
Paul J. Coleman
Publikováno v:
Space Policy Alternatives ISBN: 9780429307232
Space Policy Alternatives
Space Policy Alternatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5592a1116cf88dbf201d0ce136730d46
https://doi.org/10.4324/9780429307232-11
https://doi.org/10.4324/9780429307232-11
Autor:
Spencer D. Dreher, Nicholas K. Terrett, Emma R. Parmee, Matthew D. Truppo, Richard D. Tillyer, Robert M. Garbaccio, Kevin R. Campos, Juan C. Alvarez, Paul J. Coleman
Publikováno v:
Science (New York, N.Y.). 363(6424)
BACKGROUND Over the past century, innovations in synthetic chemistry have greatly enabled the discovery and development of important life-changing medicines, improving the health of patients worldwide. In recent years, many pharmaceutical companies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4944906dcdf6c76e77faf1e97bcee336
https://pubmed.ncbi.nlm.nih.gov/30655413
https://pubmed.ncbi.nlm.nih.gov/30655413
Autor:
Elizabeth Joshi, Zhizhen Zeng, Joseph Della Rocca, David J. Schenk, Jeffrey L. Evelhoch, Idriss Bennacef, Abbas Walji, Hyking Haley, Mona Purcell, Kerry Riffel, Serena Xu, Marie A. Holahan, Paul J. Coleman, Eric D. Hostetler, Talakad G. Lohith, Aileen Soriano, Brett Connolly, Liza Gantert, Patricia Miller, Cristian Salinas, Xiaoping Zhang, Aimie Ogawa, David Hesk
Publikováno v:
Journal of Nuclear Medicine. 57:1599-1606
A PET tracer is desired to help guide the discovery and development of disease-modifying therapeutics for neurodegenerative diseases characterized by neurofibrillary tangles (NFTs), the predominant tau pathology in Alzheimer disease (AD). We describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8733806d8e7d47383df5f2187ef2941
https://doi.org/10.2967/jnumed.115.171678
https://doi.org/10.2967/jnumed.115.171678