Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Paul J. Chiao"'
Autor:
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya’an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H. Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E. I. Mustapha Bahassi, Peter J. Stambrook, Peng Huang, Jason B. Fleming, Anirban Maitra, John A. Tainer, Mien-Chie Hung, Chunru Lin, Paul J. Chiao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways. Here, we find that development of apoptotic resistance and metastasi
Externí odkaz:
https://doaj.org/article/c655bcead33042daab28080db2e56eaa
Autor:
Christophe Glorieux, Xiaojun Xia, Xin You, Zining Wang, Yi Han, Jing Yang, Gauthier Noppe, Christophe de Meester, Jianhua Ling, Annie Robert, Hui Zhang, Sheng-Ping Li, Huamin Wang, Paul J. Chiao, Li Zhang, Xiaobing Li, Peng Huang
Publikováno v:
Journal of Advanced Research, Vol 40, Iss , Pp 109-124 (2022)
Introduction: Immunochemotherapy using PD-1/PD-L1 antibodies in combination with chemotherapeutic agents has become a mainstream treatment for cancer patients, but it remains unclear which drug combinations would produce best therapeutic outcome. Obj
Externí odkaz:
https://doaj.org/article/31e4ae69c8a84d92ae62b9fc4d2e23ad
Autor:
Zhikang Chen, Xiaobo Lai, Hui Ding, Aijun Zhang, Yufei Sun, Jianhua Ling, Paul J. Chiao, Zihua Chen, Xuefeng Xia
Publikováno v:
Cancer Innovation, Vol 1, Iss 1, Pp 55-69 (2022)
Abstract Background Limited by difficulties in early detection and availabilities of effective treatments, pancreatic cancer is a highly malignant disease with poor prognosis. Nuclear receptors are a family of ligand‐dependent transcription factors
Externí odkaz:
https://doaj.org/article/6333fd30f52643d4961f44b5cbdd2705
Autor:
Ya’an Kang, Jenying Deng, Jianhua Ling, Xinqun Li, Yi-Ju Chiang, Eugene J. Koay, Huamin Wang, Jared K. Burks, Paul J. Chiao, Mark W. Hurd, Manoop S. Bhutani, Jeffrey H. Lee, Brian R. Weston, Anirban Maitra, Naruhiko Ikoma, Ching-Wei D. Tzeng, Jeffrey E. Lee, Ronald A. DePinho, Robert A. Wolff, Shubham Pant, Florencia McAllister, Matthew H.G. Katz, Jason B. Fleming, Michael P. Kim
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with unpredictable responses to chemotherapy. Approaches to assay patient tumors before treatment and identify effective treatment regimens based on tumor sens
Externí odkaz:
https://doaj.org/article/79511496d0394ed69402ac29b6420cc6
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-16 (2021)
Abstract Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA sequencing, many circRNAs were found to be differentially expressed in various cancer c
Externí odkaz:
https://doaj.org/article/e13ce2c59e7f4e7fb7af5374ad572d7b
Autor:
Yihui Chen, Michela Capello, Mayrim V. Rios Perez, Jody V. Vykoukal, David Roife, Ya'an Kang, Laura R. Prakash, Hiroyuki Katayama, Ehsan Irajizad, Alia Fleury, Sammy Ferri-Borgogno, Dodge L. Baluya, Jennifer B. Dennison, Kim-Anh Do, Oliver Fiehn, Anirban Maitra, Huamin Wang, Paul J. Chiao, Matthew H.G. Katz, Jason B. Fleming, Samir M. Hanash, Johannes F. Fahrmann
Publikováno v:
Molecular Metabolism, Vol 56, Iss , Pp 101426- (2022)
Objective: Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC). Given other potential roles of CES2, we assessed its regulation
Externí odkaz:
https://doaj.org/article/f9a47ca82b9a4a3aa384f17421d279f9
Autor:
Christophe Glorieux, Xiaojun Xia, Yong-Qiao He, Yumin Hu, Kelly Cremer, Annie Robert, Junchen Liu, Fen Wang, Jianhua Ling, Paul J. Chiao, Peng Huang
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101780- (2021)
K-ras mutations are major genetic events that drive cancer development associated with aggressive malignant phenotypes, while expression of the immune checkpoint molecule PD-L1 plays a key role in cancer evasion of the immune surveillance that also p
Externí odkaz:
https://doaj.org/article/0f0079eb86ad4438a2e8999cb2d67cbf
Autor:
Huai-Qiang Ju, Haoqiang Ying, Tian Tian, Jianhua Ling, Jie Fu, Yu Lu, Min Wu, Lifeng Yang, Abhinav Achreja, Gang Chen, Zhuonan Zhuang, Huamin Wang, Deepak Nagrath, Jun Yao, Mien-Chie Hung, Ronald A. DePinho, Peng Huang, Rui-Hua Xu, Paul J. Chiao
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Kras activation and p16 inactivation cooperatively promote pancreatic cancer progression. Here, the authors show that such cooperation depends upon an increased expression of the NAD(P)H oxidase NOX4 achieved through transcription factors independent
Externí odkaz:
https://doaj.org/article/da3fdd9ee37641f7b1f60225dc58f787
Autor:
Kenji Yokoi, Sun-Jin Kim, Premal Thaker, Sertac Yazici, Do-Hyun Nam, Junqin He, Takamitsu Sasaki, Paul J. Chiao, Guido M. Sclabas, James L. Abbruzzese, Stanley R. Hamilton, Isaiah J. Fidler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 7, Pp 696-704 (2005)
Although gemcitabine has been accepted as the firstline chemotherapeutic reagent for advanced pancreatic cancer, improvement of response rate and survival is not sufficient and patients often develop resistance. We hypothesized that the inhibition of
Externí odkaz:
https://doaj.org/article/8ff4c531567847d083721acf39b738a1
Autor:
Paul J. Chiao, Peng Huang, Katsuhiko Yanaga, Jie Fu, Zhuo-Nan Zhuang, Min Wu, Mitzi Aguilar, Takeshi Gocho, Huai-Qiang Ju
Supplementary figure S1. Increased cellular ROS levels in PDAC cells treated with gemcitabine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ce70136414e7d1e65cece67576a4b7
https://doi.org/10.1158/1535-7163.22502187.v1
https://doi.org/10.1158/1535-7163.22502187.v1