Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Paul J. Chaplin"'
Autor:
Paul J. Chaplin, Jan M. Tennent, Ross N. P. Cahill, Peter McWaters, Robert De Rose, Wayne G. Kimpton, Jean-Pierre Y. Scheerlinck, Paul R. Wood
Publikováno v:
Veterinary Immunology and Immunopathology. 90:55-63
DNA vaccination, delivered through various routes, has been used extensively in laboratory animals. Few studies have focused on veterinary species and while results obtained in laboratory animals can often be extrapolated to veterinary species this i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae56aa5649e1daa14c994ff853dcf59b
https://doi.org/10.1016/s0165-2427(02)00221-0
https://doi.org/10.1016/s0165-2427(02)00221-0
Autor:
Jean-Pierre Y. Scheerlinck, Jan M. Tennent, Gerard Casey, Paul J. Chaplin, D. J. Woollard, Marshall W. Lightowlers, Peter McWaters, Julie Kelly
Publikováno v:
Vaccine. 19:4053-4060
A large-scale DNA vaccination trial was performed in sheep to investigate whether co-delivery of the cytokine genes IL-4, IL-5, IL-15, GM-CSF or IFN-γ could modulate the immune response generated to an antigen, in a DNA prime-recombinant protein boo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb217fd78574b23d498fed5844c2ec26
https://doi.org/10.1016/s0264-410x(01)00133-5
https://doi.org/10.1016/s0264-410x(01)00133-5
Targeting Improves the Efficacy of a DNA Vaccine against Corynebacterium pseudotuberculosis in Sheep
Autor:
Peter McWaters, Jean-Pierre Y. Scheerlinck, Jan M. Tennent, Andrew M. Lew, Paul J. Chaplin, Jefferey S. Boyle, Julie Kelly, Robert De Rose
Publikováno v:
Infection and Immunity. 67:6434-6438
A large-scale DNA vaccination trial was performed with sheep to investigate whether an antigen targeted by CTLA-4 enhanced and accelerated the humoral immune response. Vaccination with genetically detoxified phospholipase D (ΔPLD) has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14287ac54f79d28e2e405f09f4b1fd7
https://doi.org/10.1128/iai.67.12.6434-6438.1999
https://doi.org/10.1128/iai.67.12.6434-6438.1999
Autor:
Paul J. Chaplin, Martin D. Ryan, Evelyn B. Camon, Barnardo Villarreal-Ramos, R.A. Collins, Micheal Flint
Publikováno v:
Journal of Interferon & Cytokine Research. 19:235-241
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two disulfide-linked subunits (p40 and p35) encoded by separate genes. We used the apparent autocleavage property of a 2A peptide from the foot-and-mouth disease virus (FMDV) to express b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6149ea743b1bfb779be58a6191e8e571
https://doi.org/10.1089/107999099314162
https://doi.org/10.1089/107999099314162
Publikováno v:
Journal of Interferon & Cytokine Research. 16:25-30
A cDNA encoding a distinct bovine (Bo) interferon (IFN) alpha, designated BoIFN-alpha E, was generated from gut epithelial cells isolated from a rotavirus-infected calf. The BoIFN-alpha E cDNA sequence shared a greater than 90% identity with the othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab15b58ef1616fb2aa910c80f7b1d6e
https://doi.org/10.1089/jir.1996.16.25
https://doi.org/10.1089/jir.1996.16.25
Autor:
James A. Triccas, Umaimainthan Palendira, Carl G. Feng, Warwick J. Britton, Arun T. Kamath, Paul J. Chaplin, Ela Martin
More effective vaccines againstMycobacterium tuberculosismay contribute to the control of this major human pathogen. DNA vaccines encoding single mycobacterial proteins stimulate antimycobacterial T-cell responses and induce partial protection agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c590db98eb56096528fa95b6cd00441d
https://europepmc.org/articles/PMC127841/
https://europepmc.org/articles/PMC127841/
Publikováno v:
Parasite immunology. 24(2)
SUMMARY Fasciola hepatica infection has been shown to suppress sheep lymphocyte proliferation in vitro and this is at least partially attributable to excretory/secretory products (ES) released by F. hepatica parasites. We identified a suppressive com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc151027ecb090bd67c5bfc83938baa
https://pubmed.ncbi.nlm.nih.gov/11874560
https://pubmed.ncbi.nlm.nih.gov/11874560
Autor:
Jan M. Tennent, Lorraine Beezum, Alan Coulter, J-P.Y. Scheerlinck, Peter McWaters, Wayne G. Kimpton, Martin J. Pearse, R.G. Windon, Anders Sjölander, Ross N. P. Cahill, Paul J. Chaplin, Debbie Drane, M. Tzatzaris, M. Tavarnesi
Publikováno v:
Vaccine. 20(3-4)
The peripheral (draining) lymph node, as the primary site of immune induction, determines the course of systemic responses to an injected antigen. Lymphatic duct cannulation procedures in sheep were used to investigate local immunoreactivity to human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1be0a8260b0da3a62b32412bf6e1641
https://pubmed.ncbi.nlm.nih.gov/11672914
https://pubmed.ncbi.nlm.nih.gov/11672914
Publikováno v:
Europe PubMed Central
The uptake of respiratory syncytial virus (RSV) antigen by cattle dendritic cells was investigated. Pathways of antigen uptake were monitored by flow cytometry using specific tracers and by proliferation assays, which were used to measure the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239a3db8c47f031fe767b7489f7c8b30
https://pubmed.ncbi.nlm.nih.gov/10410989
https://pubmed.ncbi.nlm.nih.gov/10410989
Publikováno v:
Veterinary immunology and immunopathology. 63(1-2)
The cytokine IL-12 is a key molecule in the regulation of CD4+T cell development and specifically potentiates the development of T helper 1 responses in mouse and man. However the biological effects mediated by bovine IL-12 have not been defined in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d97c7fc0dc91404ba1db555009cd41
https://pubmed.ncbi.nlm.nih.gov/9656442
https://pubmed.ncbi.nlm.nih.gov/9656442