Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Paul J. Boersema"'
Autor:
Yansheng Liu, Christelle Borel, Li Li, Torsten Müller, Evan G. Williams, Pierre-Luc Germain, Marija Buljan, Tatjana Sajic, Paul J. Boersema, Wenguang Shao, Marco Faini, Giuseppe Testa, Andreas Beyer, Stylianos E. Antonarakis, Ruedi Aebersold
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Trisomy 21 (T21) is a major cause of Down syndrome but little is known about its impact on the cellular proteome. Here, the authors define the proteome of T21 fibroblasts and its turnover and also map proteomic differences in monozygotic T21-discorda
Externí odkaz:
https://doaj.org/article/5fd1464d14644e54b82f2a253ca5d0c7
Autor:
Timo K van den Berg, Hugo Olsman, Hanke L Matlung, Katka Franke, Imke Lodewijks, Lilian Driessen-Engels, Mary J van Helden, Seline A Zwarthoff, Roel J Arends, Inge M J Reinieren-Beeren, Marc C B C Paradé, Karin de Laat-Arts, Désirée Damming, Ellen W H Santegoeds-Lenssen, Daphne W J van Kuppeveld, Ellen Mattaar-Hepp, Marloes E M Stokman, Benny de Wit, Dirk H R F Glaudemans, Daniëlle E J W van Wijk, Lonnie Joosten-Stoffels, Jan Schouten, Paul J Boersema, Monique van der Vleuten, Jorien W H Sanderink, Wendela A Kappers, Diels van den Dobbelsteen, Marco Timmers, Ruud Ubink, Gerard J A Rouwendal, Gijs Verheijden, Miranda M C van der Lee, Wim H A Dokter
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Preclinical studies have firmly established the CD47-signal-regulatory protein (SIRP)α axis as a myeloid immune checkpoint in cancer, and this is corroborated by available evidence from the first clinical studies with CD47 blockers. Howev
Externí odkaz:
https://doaj.org/article/b070a5b304cf452fb3bfdad0492340e0
Autor:
Markus Hartl, Magdalena Füßl, Paul J Boersema, Jan‐Oliver Jost, Katharina Kramer, Ahmet Bakirbas, Julia Sindlinger, Magdalena Plöchinger, Dario Leister, Glen Uhrig, Greg BG Moorhead, Jürgen Cox, Michael E Salvucci, Dirk Schwarzer, Matthias Mann, Iris Finkemeier
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 10, Pp 1-16 (2017)
Abstract Histone deacetylases have central functions in regulating stress defenses and development in plants. However, the knowledge about the deacetylase functions is largely limited to histones, although these enzymes were found in diverse subcellu
Externí odkaz:
https://doaj.org/article/d0f8553dd4c84af98422005719471a34
Autor:
Mary J van Helden, Seline A Zwarthoff, Roel J Arends, Inge M J Reinieren-Beeren, Marc C B C Paradé, Lilian Driessen-Engels, Karin de Laat-Arts, Désirée Damming, Ellen W H Santegoeds-Lenssen, Daphne W J van Kuppeveld, Imke Lodewijks, Hugo Olsman, Hanke L Matlung, Katka Franke, Ellen Mattaar-Hepp, Marloes E M Stokman, Benny de Wit, Dirk H R F Glaudemans, Daniëlle E J W van Wijk, Lonnie Joosten-Stoffels, Jan Schouten, Paul J Boersema, Monique van der Vleuten, Jorien W H Sanderink, Wendela A Kappers, Diels van den Dobbelsteen, Marco Timmers, Ruud Ubink, Gerard J A Rouwendal, Gijs Verheijden, Miranda M C van der Lee, Wim H A Dokter, Timo K van den Berg
Publikováno v:
van Helden, M J, Zwarthoff, S A, Arends, R J, Reinieren-Beeren, I M J, Paradé, M C B C, Driessen-Engels, L, de Laat-Arts, K, Damming, D S, Santegoeds-Lenssen, E W H, van Kuppeveld, D W J, Lodewijks, I, Olsman, H, Matlung, H L, Franke, K, Mattaar-Hepp, E, Stokman, M E M, de Wit, B, Glaudemans, D H R F, van Wijk, D E J W, Joosten-Stoffels, L, Schouten, J, Boersema, P J, van der Vleuten, M, Sanderink, J W H, Kappers, W A, van den Dobbelsteen, D, Timmers, M, Ubink, R, Rouwendal, G J A, Verheijden, G, van der Lee, M M C, Dokter, W H A & van den Berg, T K 2023, ' BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγon T cells ', Journal for Immunotherapy of Cancer, vol. 11, no. 4, jitc-2022-006567 . https://doi.org/10.1136/jitc-2022-006567
BackgroundPreclinical studies have firmly established the CD47-signal-regulatory protein (SIRP)α axis as a myeloid immune checkpoint in cancer, and this is corroborated by available evidence from the first clinical studies with CD47 blockers. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f6e6308ed606888d418126a12792c8
https://research.vumc.nl/en/publications/67116c0e-064c-4154-86d3-6797beec296d
https://research.vumc.nl/en/publications/67116c0e-064c-4154-86d3-6797beec296d
Autor:
Paul J. Boersema, Francesco Bertoni, Andrea Rinaldi, Maurizio Molinari, Ilaria Fregno, Fiorenza Fumagalli, Paola Picotti, Timothy J. Bergmann
Publikováno v:
Journal of Biological Chemistry. 293:5600-5612
The stress sensors ATF6, IRE1, and PERK monitor deviations from homeostatic conditions in the endoplasmic reticulum (ER), a protein biogenesis compartment of eukaryotic cells. Their activation elicits unfolded protein responses (UPR) to re-establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5d3e70aabda7f70e829e38b0d367f7
https://doi.org/10.1074/jbc.ra117.001484
https://doi.org/10.1074/jbc.ra117.001484
Autor:
Oliver Müller, Pascal Leuenberger, Simone Schopper, Ilaria Piazza, Paul J. Boersema, Abdullah Kahraman, Paola Picotti, Yuehan Feng
Publikováno v:
Nature Protocols, 12 (11)
Protein structural changes induced by external perturbations or internal cues can profoundly influence protein activity and thus modulate cellular physiology. A number of biophysical approaches are available to probe protein structural changes, but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600a01f3f6e076993706a6a926209081
https://doi.org/10.1038/nprot.2017.100
https://doi.org/10.1038/nprot.2017.100
Autor:
Stylianos E. Antonarakis, Paul J. Boersema, Tatjana Sajic, Yansheng Liu, Andreas Beyer, Torsten Müller, Christelle Borel, Marco Faini, Giuseppe Testa, Evan G. Williams, Ruedi Aebersold, Wenguang Shao, Li Li, Marija Buljan, Pierre-Luc Germain
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications, Vol. 8, No 1 (2017) P. 1212
Nature Communications, 8 (1)
Nature Communications
Nature Communications, Vol. 8, No 1 (2017) P. 1212
Nature Communications, 8 (1)
Down syndrome (DS) is mostly caused by a trisomy of the entire Chromosome 21 (Trisomy 21, T21). Here, we use SWATH mass spectrometry to quantify protein abundance and protein turnover in fibroblasts from a monozygotic twin pair discordant for T21, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031f35cc24f70d55f492c0c3b74f2842
https://doaj.org/article/5fd1464d14644e54b82f2a253ca5d0c7
https://doaj.org/article/5fd1464d14644e54b82f2a253ca5d0c7
Autor:
Eliezer Masliah, Adriano Aguzzi, Radoslav I. Enchev, Petra Schwarz, Thibault Courtheoux, Matthias Peter, Anthony Adame, Juan Gerez, Paola Picotti, Paul J. Boersema, Uli S. Herrmann, Natalia Cecilia Prymaczok, Roland Riek, Edward Rockenstein
Parkinson’s disease (PD) is a neurological disorder characterized by the progressive accumulation of neuronal α-synuclein (αSyn) inclusions called Lewy bodies. It is believed that Lewy bodies spread throughout the nervous system due to the cell-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21036f343bf70896f02fe82414a6570
https://doi.org/10.5167/uzh-172491
https://doi.org/10.5167/uzh-172491
Autor:
Sandrine C. Foti, Ulrich Wagner, Florent Laferrière, Paul J. Boersema, Magdalini Polymenidou, Erwan Bezard, Marian Hruska-Plochan, Tammaryn Lashley, Amanda J Lewis, Ashraf Al-Amoudi, Francesca De Giorgi, Yasmine T. Asi, Henning Stahlberg, Larissa A. B. Gilhespy, Zuzanna Maniecka, Eva-Maria Hock, Paola Picotti, Gery Barmettler, Tariq Afroz, Adrian M. Isaacs, John Ravits, François Ichas, Manuela Pérez-Berlanga
Publikováno v:
Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2019, 22 (1), pp.65-77. ⟨10.1038/s41593-018-0294-y⟩
Nature Neuroscience, 2019, 22 (1), pp.65-77. ⟨10.1038/s41593-018-0294-y⟩
Nature Neuroscience, Nature Publishing Group, 2019, 22 (1), pp.65-77. ⟨10.1038/s41593-018-0294-y⟩
Nature Neuroscience, 2019, 22 (1), pp.65-77. ⟨10.1038/s41593-018-0294-y⟩
International audience; Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d65522d507f8f98fb08f2c4a3944e6
https://hal.archives-ouvertes.fr/hal-02492708
https://hal.archives-ouvertes.fr/hal-02492708
Autor:
Paul J. Boersema, Roman A. Zubarev, Paola Picotti, Bouke P. C. Hazenberg, Junichi Kamiie, Magdalini Polymenidou, Andre Melnik, György Marko-Varga, Erik Portelius, Kaj Blennow, Melinda Rezeli
Publikováno v:
Journal of Proteome Research, 17(12), 4072-4084. NLM (Medline)
The Biology/Disease-driven (B/D) working groups of the Human Proteome Project are alliances of research groups aimed at developing or improving proteomic tools to support specific biological or disease-related research areas. Here, we describe the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac3e9723f9cc42a7d3dc02611e008f9
https://doi.org/10.5167/uzh-180857
https://doi.org/10.5167/uzh-180857