Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Paul J. Barton"'
Autor:
Daniel Hellfeld, Mark S. Bandstra, Jayson R. Vavrek, Donald L. Gunter, Joseph C. Curtis, Marco Salathe, Ryan Pavlovsky, Victor Negut, Paul J. Barton, Joshua W. Cates, Brian J. Quiter, Reynold J. Cooper, Kai Vetter, Tenzing H. Y. Joshi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The ability to map and estimate the activity of radiological source distributions in unknown three-dimensional environments has applications in the prevention and response to radiological accidents or threats as well as the enforcement and v
Externí odkaz:
https://doaj.org/article/223ecb5a2caf4cb3b13e04018d25b2a2
Autor:
Heba Sh. Kassem, Roddy Walsh, Paul J. Barton, Besra S. Abdelghany, Remon S. Azer, Rachel Buchan, Shibu John, Ahmed Elguindy, Sarah Moharem-ElGamal, Hala M. Badran, Hoda Shehata, Stuart A. Cook, Magdi H. Yacoub
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 18, Iss 4, Pp 381-387 (2017)
Background: NGS enables simultaneous sequencing of large numbers of associated genes in genetic heterogeneous disorders, in a more rapid and cost-effective manner than traditional technologies. However there have been limited direct comparisons betwe
Externí odkaz:
https://doaj.org/article/0c6f1fead1724d898d4dc8c69c82896f
Autor:
Matthias Heinig, Michiel E. Adriaens, Sebastian Schafer, Hanneke W. M. van Deutekom, Elisabeth M. Lodder, James S. Ware, Valentin Schneider, Leanne E. Felkin, Esther E. Creemers, Benjamin Meder, Hugo A. Katus, Frank Rühle, Monika Stoll, François Cambien, Eric Villard, Philippe Charron, Andras Varro, Nanette H. Bishopric, Alfred L. George, Cristobal dos Remedios, Aida Moreno-Moral, Francesco Pesce, Anja Bauerfeind, Franz Rüschendorf, Carola Rintisch, Enrico Petretto, Paul J. Barton, Stuart A. Cook, Yigal M. Pinto, Connie R. Bezzina, Norbert Hubner
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-21 (2017)
Abstract Background Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. Results Here we report the first in-depth survey of heart
Externí odkaz:
https://doaj.org/article/8e7bacbcd5ca43fa9bd815bc4899b453
Autor:
Amrit S Lota, Mark Hazebroek, Pantazis Theotokis, Rebecca Wassall, Sara Salmi, Brian Halliday, Upasana Tayal, Job Verdonschot, Devendra Meena, Antonio de Marvao, Alma Iacob, Daniel Hammersley, Richard Jones, Rick Wage, Rachel Buchan, Momina Yazdani, Michela Noseda, Tarun Mittal, Joyce Wong, Jan Lukas Robertus, John Baksi, Vassilios Vassiliou, Ioanna Tzoulaki, Antonios Pantazis, John Cleland, Paul J Barton, stuart cook, Dudley J Pennell, Pablo Garcia-Pavia, Leslie T Cooper, Stephane Heymans, James S Ware, Sanjay K Prasad
Publikováno v:
Circulation. 144
Background: Myocarditis may predispose to dilated cardiomyopathy (DCM) and sudden cardiac death (SCD). Familial data indicate a potential genetic susceptibility shared with arrhythmogenic cardiomyopathy (ACM). We present the first large-scale genotyp
Autor:
Angela Clerk, Daniel N. Meijles, Michelle A. Hardyman, Stephen J. Fuller, Sonia P. Chothani, Joshua J. Cull, Susanna T.E. Cooper, Hajed O. Alharbi, Konstantinos Vanezis, Leanne E. Felkin, Thomais Markou, Samuel J. Leonard, Spencer W. Shaw, Owen J.L. Rackham, Stuart A. Cook, Peter E. Glennon, Mary N. Sheppard, John C. Sembrat, Mauricio Rojas, Charles F. McTiernan, Paul J. Barton, Peter H. Sugden
Publikováno v:
The Biochemical journal. 479(3)
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human hear
Autor:
Neeta Adhikari, Weihua Guan, Brian Capaldo, Aaron J Mackey, Marjorie Carlson, Sundaram Ramakrishnan, Dinesha Walek, Manu Gupta, Adam Mitchell, Peter Eckman, Ranjit John, Euan Ashley, Paul J Barton, Jennifer L Hall
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101509 (2014)
The rationale was to utilize a bioinformatics approach to identify miRNA binding sites in genes with single nucleotide mutations (SNPs) to discover pathways in heart failure (HF).The objective was to focus on the genes containing miRNA binding sites
Externí odkaz:
https://doaj.org/article/0379751938e2429a943bd0f3776b3f91
Autor:
Ben, Corden, Julian, Jarman, Nicola, Whiffin, Upasana, Tayal, Rachel, Buchan, Joban, Sehmi, Andrew, Harper, William, Midwinter, Karen, Lascelles, Vias, Markides, Mark, Mason, John, Baksi, Antonis, Pantazis, Dudley J, Pennell, Paul J, Barton, Sanjay K, Prasad, Tom, Wong, Stuart A, Cook, James S, Ware
Publikováno v:
JAMA Network Open
This cohort study investigates the association of titin-truncating genetic variants with life-threatening ventricular arrhythmias in adult patients with dilated cardiomyopathy who have implanted cardiac defibrillators or cardiac resynchronization the
Autor:
Fernando Domínguez, Sofía Cuenca, Zofia Bilińska, Rocío Toro, Eric Villard, Roberto Barriales-Villa, Juan Pablo Ochoa, Folkert Asselbergs, Arjan Sammani, Maria Franaszczyk, Mohammed Akhtar, Maria José Coronado-Albi, Diego Rangel-Sousa, Jose F. Rodriguez-Palomares, Juan Jiménez-Jáimez, José Manuel Garcia-Pinilla, Tomás Ripoll-Vera, Maria Victoria Mogollón-Jiménez, Ana Fontalba-Romero, Dolores Garcia-Medina, Julian Palomino-Doza, David de Gonzalo-Calvo, Marcos Cicerchia, Joel Salazar-Mendiguchia, Clara Salas, Sabine Pankuweit, Thomas Morris Hey, Jens Mogensen, Paul J. Barton, Philippe Charron, Perry Elliott, Pablo Garcia-Pavia, Hans Eiskjær, Roberto Barriales, Xusto Fernández Fernández, Lorenzo Monserrat, Maria Victoria Mogollón, Tomás Ripoll, Pascale Richard, Julian Palomino Doza, Ana Fontalba, Luis Alonso-Pulpón, Marta Cobo-Marcos, Manuel Gómez-Bueno, Esther González-López, Aitor Hernández-Hernández, Francisco José Hernández-Pérez, Ángela López-Sainz, Alejandra Restrepo-Córdoba, Javier Segovia-Cubero, Rocio Toro, Félix Rosa Longobardo, Javier Limeres, Jose Manuel Garcia-Pinilla, Miguel A. López-Garrido, Juan Jiménez-Jaimez, Diego Rangel Sousa, Maria Luisa Peña, Thomas Morris-Hey, Stuart A. Cook, William Midwinter, Angharad M. Roberts, James S. Ware, Roddy Walsh, Perry M. Elliott, Luis Rocha-Lopes, Konstantinos Savvatis, Petros Syrris, Ewa Michalak, Rafal Ploski, Malgorzata Sobieszczanska-Malek, Annette Baas, Dennis Dooijes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
European Genetic Cardiomyopathies Initiative Investigators 2018, ' Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations ', Journal of the American College of Cardiology, vol. 72, no. 20, pp. 2471-2481 . https://doi.org/10.1016/j.jacc.2018.08.2181
Journal of the American College of Cardiology, 72(20), 2471-2481. Elsevier USA
Journal of the American College of Cardiology, 72(20), 2471. Elsevier USA
instname
European Genetic Cardiomyopathies Initiative Investigators 2018, ' Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations ', Journal of the American College of Cardiology, vol. 72, no. 20, pp. 2471-2481 . https://doi.org/10.1016/j.jacc.2018.08.2181
Journal of the American College of Cardiology, 72(20), 2471-2481. Elsevier USA
Journal of the American College of Cardiology, 72(20), 2471. Elsevier USA
[Background] The BAG3 (BLC2-associated athanogene 3) gene codes for an antiapoptotic protein located on the sarcomere Z-disc. Mutations in BAG3 are associated with dilated cardiomyopathy (DCM), but only a small number of cases have been reported to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c004afefe87b9030135940c3623712d
http://hdl.handle.net/10261/176842
http://hdl.handle.net/10261/176842
Autor:
Ben Corden, Julian Jarman, Nicola Whiffin, Upasana Tayal, Rachel Buchan, Joban Sehmi, Andrew Harper, William Midwinter, Karen Lascelles, Vias Markides, Mark Mason, Dudley J Pennell, Paul J Barton, Sanjay K Prasad, Tom Wong, Stuart A Cook, James S Ware
Publikováno v:
Circulation. 136
Introduction: There is an urgent need for better arrhythmic risk stratification in non-ischaemic dilated cardiomyopathy (DCM), where the benefit of ICD implantation is unclear. Titin truncating variants (TTNtv) are the commonest genetic cause of DCM
Autor:
Roddy, Walsh, Rachel, Buchan, Alicja, Wilk, Shibu, John, Leanne E, Felkin, Kate L, Thomson, Tang Hak, Chiaw, Calvin Chin Woon, Loong, Chee Jian, Pua, Claire, Raphael, Sanjay, Prasad, Paul J, Barton, Birgit, Funke, Hugh, Watkins, James S, Ware, Stuart A, Cook
Publikováno v:
European Heart Journal
Aim Hypertrophic cardiomyopathy (HCM) exhibits genetic heterogeneity that is dominated by variation in eight sarcomeric genes. Genetic variation in a large number of non-sarcomeric genes has also been implicated in HCM but not formally assessed. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b2713a07ff32cf161f9dd93ab5796619
http://hdl.handle.net/10044/1/55752
http://hdl.handle.net/10044/1/55752