Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Paul J. Bédard"'
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 266-272 (2005)
Storage of motor memory involves the basal ganglia and more precisely the striatum, which receives afferents from all regions of the cerebral cortex. In Parkinsonian (MPTP) monkeys, we observed an increase in the dyskinetic response to dopaminergic a
Externí odkaz:
https://doaj.org/article/a45d74c0e0544148adb1a7d1c9611ede
Autor:
Abdallah Hadj-Tahar, Robert A. Hodgson, Thérèse Di Paolo, Tatiana M. Kazdoba, Andrew Stamford, Paul J. Bédard, Annamarie Pond, Aurelie Dare, Laurent Grégoire, John C. Hunter, Geoffrey B. Varty, Michael Grzelak, Bernard R. Neustadt, Nancy Bélanger
Publikováno v:
Experimental Neurology. 225:384-390
Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a259cd1902b557fbeef2d74fff789ae2
https://doi.org/10.1016/j.expneurol.2010.07.011
https://doi.org/10.1016/j.expneurol.2010.07.011
Autor:
Thérèse Di Paolo, Julie Graham, Paul J. Bédard, Gerd Bartoszyk, Pershia Samadi, Laurent Grégoire
Publikováno v:
Parkinsonism & Related Disorders. 15:445-452
Dyskinesia is an important complication of treatment in Parkinson's disease (PD). Sarizotan, a 5-HT1A agonist with high affinity for D3 and D4 receptors was investigated on l -Dopa-induced dyskinesia (LID) in the 1-methyl-4-phenyl-1,2,3,6-tetrahydrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969565b6b48de3e809fbaefeeb6db933
https://doi.org/10.1016/j.parkreldis.2008.11.001
https://doi.org/10.1016/j.parkreldis.2008.11.001
Autor:
Leonard T. Meltzer, Thérèse Di Paolo, Pershia Samadi, Frédéric Calon, Laurent Grégoire, Abdallah Hadj Tahar, Nancy Bélanger, Paul J. Bédard, Marc Morissette, Mehdi Dridi
Publikováno v:
Neurobiology of Aging. 29:1040-1051
Modulation of excessive glutamatergic transmission within the basal ganglia is considered as an alternative approach to reduce l-Dopa-induced dyskinesias (LIDs) in Parkinson's disease (PD). In this study receptor binding autoradiography of [3H]MPEP,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7544607520c21ce2edd19812c34f3f8e
https://doi.org/10.1016/j.neurobiolaging.2007.02.005
https://doi.org/10.1016/j.neurobiolaging.2007.02.005
Autor:
Pershia Samadi, Thérèse Di Paolo, Robert Schwarcz, Arash Rassoulpour, Emanuela Izzo, Paolo Guidetti, Paul J. Bédard, Laurent Grégoire
Publikováno v:
Behavioural Brain Research. 186:161-167
Increased glutamatergic activity is believed to play a significant role in the development of levodopa-induced dyskinesias (LID). LID may therefore be attenuated by a reduction in glutamatergic function. This was tested pharmacologically in MPTP monk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66960d1a452174cc0b63350c675ef946
https://doi.org/10.1016/j.bbr.2007.08.007
https://doi.org/10.1016/j.bbr.2007.08.007
Publikováno v:
Neurobiology of Aging. 27:1684-1693
The steroid dehydroepiandrosterone (DHEA) is abundant in men and women and decreases rapidly during aging. Parkinson's disease (PD) is the second most common neurodegenerative disorder just behind Alzheimer. l-3,4-Dihydroxyphenylalanine (l-Dopa) ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abd207490ddf532055a95b58261b5b8
https://doi.org/10.1016/j.neurobiolaging.2005.09.028
https://doi.org/10.1016/j.neurobiolaging.2005.09.028
Autor:
Frédéric Calon, Pierre Julien, Line Berthiaume, Abdallah Hadj-Tahar, Carl Julien, Thérèse Di Paolo, Paul J. Bédard, Ali H. Rajput
Publikováno v:
Neurochemistry International. 48:404-414
Fatty acids play a critical role in brain function but their specific role in the pathophysiology of Parkinson disease (PD) and levodopa-induced motor complications is still unknown. From a therapeutic standpoint, it is important to determine the rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea37d196e2317d71464800a907ee3d0
https://doi.org/10.1016/j.neuint.2005.12.002
https://doi.org/10.1016/j.neuint.2005.12.002
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 314:1248-1256
The purpose of this study is to demonstrate that sumanirole is a novel dopamine receptor agonist with high in vitro and in vivo selectivity for the D(2) receptor subtype. Sumanirole, (R)-5,6-dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea17fe04abd092489b80fc8b0955367
https://doi.org/10.1124/jpet.105.084202
https://doi.org/10.1124/jpet.105.084202
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 266-272 (2005)
Storage of motor memory involves the basal ganglia and more precisely the striatum, which receives afferents from all regions of the cerebral cortex. In Parkinsonian (MPTP) monkeys, we observed an increase in the dyskinetic response to dopaminergic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0e3ef14aed75ac1c710cf020a4d606
http://www.sciencedirect.com/science/article/pii/S0969996105000082
http://www.sciencedirect.com/science/article/pii/S0969996105000082
Autor:
Paul J. Bédard, Richard Grondin, Abdallah Hadj Tahar, Pershia Samadi, Pierre J. Blanchet, Leonard T. Meltzer, Marc Morissette, Frédéric Calon, Laurent Grégoire, Thérèse Di Paolo, Nancy Bélanger
Publikováno v:
Parkinsonism & Related Disorders. 10:297-304
For nearly 20 years, the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model has allowed great strides to be made in our understanding of the maladaptive changes underlying the levodopa-related motor response complications occurring in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37be3aff5ad8a33f93cb7c72559e4d1
https://doi.org/10.1016/j.parkreldis.2004.02.011
https://doi.org/10.1016/j.parkreldis.2004.02.011