Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Paul J. Adam"'
Autor:
Leticia Corrales, Susanne Hipp, Katharina Martin, Nicolas Sabarth, Iñigo Tirapu, Klaus Fuchs, Barbara Thaler, Christian Walterskirchen, Kathrin Bauer, Markus Fabits, Michael Bergmann, Carina Binder, Paolo ML. Chetta, Anne B. Vogt, Paul J. Adam
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Colorectal cancer (CRC) is one of the most common cancers worldwide and demands more effective treatments. We sought to identify tumor selective CRC antigens and their therapeutic potential for cytotoxic T-cell targeting by transcriptomic and immunoh
Externí odkaz:
https://doaj.org/article/4e657dd29c1a4cc39eab8fbf55b96587
Publikováno v:
Antibodies, Vol 9, Iss 4, p 65 (2020)
T-cell Engaging bispecific antibodies (TcEs) that can re-direct cytotoxic T-cells to kill cancer cells have been validated in clinical studies. To date, the clinical success with these agents has mainly been seen in hematologic tumor indications. How
Externí odkaz:
https://doaj.org/article/e2d56adc7fe64fd6a72748680d8fff3e
Autor:
Paul J. Adam, Günther Adolf, Michael N. Pollak, Eric Borges, Christian Koessl, Herbert R. Lamche, Elinborg Ostermann, Monika Kroez, Marco H. Hofmann, Katrin Friedbichler
PDF - 385KB, IGF and insulin receptor mRNA expression in RD-ES and GEO cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa4f6f55342c01f8b95692174be86e1
https://doi.org/10.1158/1535-7163.22499922.v1
https://doi.org/10.1158/1535-7163.22499922.v1
Autor:
Paul J. Adam, Günther Adolf, Michael N. Pollak, Eric Borges, Christian Koessl, Herbert R. Lamche, Elinborg Ostermann, Monika Kroez, Marco H. Hofmann, Katrin Friedbichler
PDF - 595KB, Correlation of rapamycin-induced AKT phosphorylation with effect of BI 836845 treatment on cell viability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04217f702743961db0ce97d1c0a2cea0
https://doi.org/10.1158/1535-7163.22499919.v1
https://doi.org/10.1158/1535-7163.22499919.v1
Autor:
Paul J. Adam, Günther Adolf, Michael N. Pollak, Eric Borges, Christian Koessl, Herbert R. Lamche, Elinborg Ostermann, Monika Kroez, Marco H. Hofmann, Katrin Friedbichler
Insulin-like growth factor (IGF) signaling is thought to play a role in the development and progression of multiple cancer types. To date, therapeutic strategies aimed at disrupting IGF signaling have largely focused on antibodies that target the IGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73de9e5357d0ab6ad2de6d1e242b8831
https://doi.org/10.1158/1535-7163.c.6536307
https://doi.org/10.1158/1535-7163.c.6536307
Autor:
Thomas Bogenrieder, Stephen R. Plymate, Cynthia C. Sprenger, Gang Liu, Eva Corey, Holly M. Nguyen, Norbert Kraut, Flavio Solca, Paul J. Adam, Rosa Baumgartinger, Katrin Friedbichler, Marco H. Hofmann, Ulrike Weyer-Czernilofsky
Supplementary Methods. Supplementary Table S1 shows the dates of mycoplasma testing and STR analysis for each cell line; Supplementary Table S2 shows the primary antibodies used for Western blot or Simple Western{trade mark, serif} analysis, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059bd5de6643f221e7f188a742a690ee
https://doi.org/10.1158/1535-7163.22507077.v1
https://doi.org/10.1158/1535-7163.22507077.v1
Autor:
Paul J. Adam, Günther Adolf, Michael N. Pollak, Eric Borges, Christian Koessl, Herbert R. Lamche, Elinborg Ostermann, Monika Kroez, Marco H. Hofmann, Katrin Friedbichler
PDF - 124KB, Supplementary Materials and Methods describing 2D cell viability assays, Western blot and qRT-PCR analyses, and determination of total rat serum IGF-1 levels and ex vivo IGF-1 bioactivity; Supplementary Table 1 (summary of BI 836845 bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377f3cd61423d321ca452f220a0df01a
https://doi.org/10.1158/1535-7163.22499913.v1
https://doi.org/10.1158/1535-7163.22499913.v1
Autor:
Paul J. Adam, Günther Adolf, Michael N. Pollak, Eric Borges, Christian Koessl, Herbert R. Lamche, Elinborg Ostermann, Monika Kroez, Marco H. Hofmann, Katrin Friedbichler
PDF - 421KB, Schematic illustrating the mechanism of synergy for BI 836845 and rapamycin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa31f63c9cfcbbc22cd92b2398a8dd4
https://doi.org/10.1158/1535-7163.22499916.v1
https://doi.org/10.1158/1535-7163.22499916.v1
Autor:
Thomas Bogenrieder, Stephen R. Plymate, Cynthia C. Sprenger, Gang Liu, Eva Corey, Holly M. Nguyen, Norbert Kraut, Flavio Solca, Paul J. Adam, Rosa Baumgartinger, Katrin Friedbichler, Marco H. Hofmann, Ulrike Weyer-Czernilofsky
Androgen deprivation therapy and second-generation androgen receptor signaling inhibitors such as enzalutamide are standard treatments for advanced/metastatic prostate cancer. Unfortunately, most men develop resistance and relapse; signaling via insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::607ee0b1f3a72eb901c30c873587dfde
https://doi.org/10.1158/1535-7163.c.6538572.v1
https://doi.org/10.1158/1535-7163.c.6538572.v1
Autor:
Susanne Hipp, Paul J. Adam, Vladimir Voynov, Craig Giragossian, Arnima Bisht, Martin P. Barnes, Lindsey J. Hudson, Anne B. Vogt, Leticia Corrales, Carina Binder, Michael Bergmann, Markus Fabits, Farzaneh Sayedian, Ling Yang, Yu-Hsi Lin, Kathrin Bauer, Christian Walterskirchen, Xiaoyun Liao, Aurélie Auguste, Wei Zhang
Purpose:Advanced-stage gastrointestinal cancers represent a high unmet need requiring new effective therapies. We investigated the antitumor activity of a novel T cell–engaging antibody (B7-H6/CD3 ITE) targeting B7-H6, a tumor-associated antigen th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eff614389ecd9231034633c4eb4db76
https://doi.org/10.1158/1078-0432.c.6532800
https://doi.org/10.1158/1078-0432.c.6532800