Výsledky vyhledávání - "Paul J. O’Brien"

Akademický článek

Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina.

Autor: Ágnes I Berta, Kathleen Boesze-Battaglia, Sem Genini, Orly Goldstein, Paul J O'Brien, Ágoston Szél, Gregory M Acland, William A Beltran, Gustavo D Aguirre

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24074 (2011)

A homozygous mutation in STK38L in dogs impairs the late phase of photoreceptor development, and is followed by photoreceptor cell death (TUNEL) and proliferation (PCNA, PHH3) events that occur independently in different cells between 7-14 weeks of a

Externí odkaz: https://doaj.org/article/ef3cee9753b54707876ef03d7b12fd55

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Bio-Orthogonal Mediated Nucleic Acid Transfection of Cells via Cell Surface Engineering

Autor: Muhammad N. Yousaf, Sina Elahipanah, Paul J. O’Brien, Dmitry Rogozhnikov

Publikováno v: ACS Central Science, Vol 3, Iss 5, Pp 489-500 (2017)
ACS Central Science

The efficient delivery of foreign nucleic acids (transfection) into cells is a critical tool for fundamental biomedical research and a pillar of several biotechnology industries. There are currently three main strategies for transfection including re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948b5eb84d89e7e64c0583cb6864e51e
https://doaj.org/article/fd9f90968f754a30bbcda8f42470232c

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Spheroid and Tissue Assembly via Click Chemistry in Microfluidic Flow

Autor: Jean Chen, Muhammad N. Yousaf, Dmitry Rogozhnikov, Paul J. O’Brien, Wei Luo

Publikováno v: Bioconjugate Chemistry. 26:1939-1949

Proper cell-cell contact and communication are essential for the correct development and survival of higher order organisms. In order to study complex cell interactions that occur in vivo, model systems that are able to recapitulate 3D cell-cell inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc38d428defbbad40f1f6a015915b84
https://doi.org/10.1021/acs.bioconjchem.5b00376

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General Dialdehyde Click Chemistry for Amine Bioconjugation

Autor: Paul J. O’Brien, Dmitry Rogozhnikov, Muhammad N. Yousaf, Sina Elahipanah

Publikováno v: Bioconjugate chemistry. 28(5)

The development of methods for conjugating a range of molecules to primary amine functional groups has revolutionized the fields of chemistry, biology, and material science. The primary amine is a key functional group and one of the most important nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b2971e721d88ba11cf40a6d7b0ce9
https://pubmed.ncbi.nlm.nih.gov/28436674

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Scaffold Free Bio-orthogonal Assembly of 3-Dimensional Cardiac Tissue via Cell Surface Engineering

Autor: Paul J. O’Brien, Dmitry Rogozhnikov, Muhammad N. Yousaf, Sina Elahipanah

Publikováno v: Scientific Reports

There has been tremendous interest in constructing in vitro cardiac tissue for a range of fundamental studies of cardiac development and disease and as a commercial system to evaluate therapeutic drug discovery prioritization and toxicity. Although t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dcd34f8d6a5d54d19b752988aaa6141

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Generation of a Scaffold-Free Three-Dimensional Liver Tissue via a Rapid Cell-to-Cell Click Assembly Process

Autor: Dmitry Rogozhnikov, Muhammad N. Yousaf, Sina Elahipanah, Paul J. O’Brien, Wei Luo

Publikováno v: Bioconjugate chemistry. 27(9)

There has been tremendous interest in constructing in vitro liver organ models for a range of fundamental studies of cell signaling, metabolism, and infectious diseases, and as a commercial system to evaluate therapeutic drug discovery prioritization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0275855c916298187b2f3b46a62f8c
https://pubmed.ncbi.nlm.nih.gov/27508505

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Rewiring Gram-Negative Bacteria Cell Surfaces with Bio-Orthogonal Chemistry via Liposome Fusion

Autor: Paul J. O’Brien, Dmitry Rogozhnikov, Wei Luo, Muhammad N. Yousaf, Parham Radmanesh, Sina Elahipanah

Publikováno v: Bioconjugate chemistry. 27(4)

The ability to tailor bacteria cell surfaces with non-native molecules is critical to advance the study of bacteria communication, cell behavior, and for next-generation therapeutics to improve livestock and human health. Such modifications would all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90bf255c3f566abc047b3879bd6479be
https://pubmed.ncbi.nlm.nih.gov/27019118

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