Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Paul J. Kemp"'
Autor:
Charlene Smith-Geater, Sarah J. Hernandez, Ryan G. Lim, Miriam Adam, Jie Wu, Jennifer T. Stocksdale, Brook T. Wassie, Maxwell Philip Gold, Keona Q. Wang, Ricardo Miramontes, Lexi Kopan, Iliana Orellana, Shona Joy, Paul J. Kemp, Nicholas D. Allen, Ernest Fraenkel, Leslie M. Thompson
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 406-419 (2020)
Summary: Aberrant neuronal development and the persistence of mitotic cellular populations have been implicated in a multitude of neurological disorders, including Huntington's disease (HD). However, the mechanism underlying this potential pathology
Externí odkaz:
https://doaj.org/article/ec7c074fe8934cefbe2687c75ff40f03
Autor:
Veronica J. Garcia, David J. Rushton, Colton M. Tom, Nicholas D. Allen, Paul J. Kemp, Clive N. Svendsen, Virginia B. Mattis
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
In Huntington’s disease (HD), while the ubiquitously expressed mutant Huntingtin (mtHTT) protein primarily compromises striatal and cortical neurons, glia also undergo disease-contributing alterations. Existing HD models using human induced pluripo
Externí odkaz:
https://doaj.org/article/7009091143fd4c03ba857bb05ef20179
Autor:
Fraser I. Young, Vsevolod Telezhkin, Sarah J. Youde, Martin S. Langley, Maria Stack, Paul J. Kemp, Rachel J. Waddington, Alastair J. Sloan, Bing Song
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Cellular heterogeneity presents an important challenge to the development of cell-based therapies where there is a fundamental requirement for predictable and reproducible outcomes. Transplanted Dental Pulp Stem/Progenitor Cells (DPSCs) have demonstr
Externí odkaz:
https://doaj.org/article/6509d82a57d045c7a208ed29b28e0525
Autor:
Leanne Grimes, Paul J. Kemp, Andrea Brancale, Mark T. Young, Wynand van der Goes van Naters, Gaia Pasqualetto, Julia Griffiths
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
The P2X receptor family of ATP-gated cation channels are attractive drug targets for pain and inflammatory disease, but no subtype-selective agonists, and few partially selective agonists have been described to date. As proof-of-concept for the disco
Autor:
Jeremy P.T. Ward, Christopher Corrigan, Beth Mansfield, Kasope L. Wolffs, Petar A. Popov, Daniel A. Pass, Daniela Riccardi, Richard T. Bruce, Paul J. Kemp, Benjamin D. Hope-Gill
Publikováno v:
Molecular pathology and functional genomics.
Autor:
Marco Straccia, Gerardo Garcia-Diaz Barriga, Phil Sanders, Georgina Bombau, Jordi Carrere, Pedro Belio Mairal, Ngoc-Nga Vinh, Sun Yung, Claire M Kelly, Clive N Svendsen, Paul J Kemp, Jamshid Arjomand, Ryan C Schoenfeld, Jordi Alberch, Nicholas D Allen, Anne E Rosser, Josep M Canals
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
A systematic characterization of the spatio-temporal gene expression during human neurodevelopment is essential to understand brain function in both physiological and pathological conditions. In recent years, stem cell technology has provided an in v
Externí odkaz:
https://doaj.org/article/a9286052aa584356b06eb800c8941e2b
Autor:
Ngoc-Nga Vinh, Ana Garcia, Anne Elizabeth Rosser, Oliver J.M. Bartley, Nigel Williams, Sophie Victoria Precious, Victoria H. Roberton, Christian Schnell, Paul J. Kemp, Narawadee Choompoo, Claire Kelly
Publikováno v:
Cytotherapy
Background\ud Cell replacement therapy (CRT) for Huntington disease (HD) requires a source of striatal (STR) progenitors capable of restoring the function lost due to STR degeneration. Authentic STR progenitors can be collected from the fetal putativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2522f84cfab752648295a4e6a12ab8
https://orca.cardiff.ac.uk/id/eprint/137641/1/PIIS146532492030760X.pdf
https://orca.cardiff.ac.uk/id/eprint/137641/1/PIIS146532492030760X.pdf
Autor:
Sarah C Brennan, Brenda A Finney, Maria Lazarou, Anne E Rosser, Caroline Scherf, Dirk Adriaensen, Paul J Kemp, Daniela Riccardi
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80294 (2013)
Airway branching morphogenesis in utero is essential for optimal postnatal lung function. In the fetus, branching morphogenesis occurs during the pseudoglandular stage (weeks 9-17 of human gestation, embryonic days (E)11.5-16.5 in mouse) in a hyperca
Externí odkaz:
https://doaj.org/article/a3992367cf884c8992808814a86c0540
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81031 (2013)
Optimal use of patient-derived, induced pluripotent stem cells for modeling neuronal diseases is crucially dependent upon the proper physiological maturation of derived neurons. As a strategy to develop defined differentiation protocols that optimize
Externí odkaz:
https://doaj.org/article/42295f54848f43cdaf8f8e2ed2c79e74
Autor:
David R Thickett, Bethan Mansfield, Ian Mudway, Tzer-Ren Ho, Luis A. J. Mur, Paul J. Kemp, Zoe Cariad Prytherch, Daniela Riccardi, Simon Scofield, Sebastian T Lugg, Christopher Corrigan, Jeremy P.T. Ward, Catherine M. Hawrylowicz, Keir Lewis
Publikováno v:
Airway cell biology and immunopathology.
Introduction: Previously we have shown that blockers of the calcium-sensing receptor (CaSR, calcilytics), reduce BHR, inflammation and remodelling in Th2/IgE- and alarmin-driven asthma models. Exposure to urban particulate matter (UPM) exacerbates as