Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Paul J Sheskey"'
Publikováno v:
Journal of Pharmaceutical Sciences. 102:4330-4336
Hot-melt granulation (HMG) by twin screw extrusion is a novel technology for the continuous processing of pharmaceuticals but confidence must still be gained regarding whether the environment affects drug properties. In this preliminary study, granul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03eff8c348cff5471aeaea807d727bd1
https://doi.org/10.1002/jps.23739
https://doi.org/10.1002/jps.23739
Publikováno v:
The Canadian Journal of Chemical Engineering. 91:725-730
This research investigated a new technique known as foam granulation for the continuous manufacturing of pharmaceuticals by a twin screw extruder. Six grades of hypromellose were compared as binders in the trials, using two addition methods: foam inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e425c61d008e4ae8867757e58072f57c
https://doi.org/10.1002/cjce.21748
https://doi.org/10.1002/cjce.21748
Publikováno v:
Powder Technology. 228:339-348
Foam granulation is a newly developed method for the wet agglomeration of powders, displaying much improved process stability in extrusion machinery compared to conventional drop-wise liquid addition approaches. This paper examines aspects of foamed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58470e19708fa80dea52e027609f61ef
https://doi.org/10.1016/j.powtec.2012.05.050
https://doi.org/10.1016/j.powtec.2012.05.050
Publikováno v:
Drug Development and Industrial Pharmacy. 38:771-784
This paper investigates foam granulation in a twin screw extruder as a new continuous wet granulation technique for pharmaceutical powder drug formulations. Foamed aqueous binder has a reportedly lower soak-to-spread ratio than drop or spray liquid a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2d649127a0888801c0e287e2a1d117
https://doi.org/10.3109/03639045.2011.633265
https://doi.org/10.3109/03639045.2011.633265
Autor:
Karen M. Balwinski, Stacey L. Dean, Paul J. Sheskey, Hui Shao, Debora L. Holbrook, Karen A. Coppens, Mladen Ladika, J. Keith Harris, Thomas H. Kalantar
Publikováno v:
Journal of Applied Polymer Science. 131
Polyampholyte latexes can exist within a certain pH range as low-viscosity aqueous dispersions, while upon a pH shift to the vicinity of the isoelectric point they undergo ionic coacervation. Three classes of coacervation latexes were synthesized and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8410ddf7bcea5da9e7cbaf749ef0f8c3
https://doi.org/10.1002/app.40049
https://doi.org/10.1002/app.40049
Publikováno v:
Drug development and industrial pharmacy. 41(1)
The influence of filler selection in wet granulation was studied for the novel case where the binder is delivered as an unstable, semi-rigid aqueous foam to an extrusion process. The work primarily examined the impact of differing concentrations of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc51d784e6c0d3cfe67fa3178e70416
https://pubmed.ncbi.nlm.nih.gov/24111830
https://pubmed.ncbi.nlm.nih.gov/24111830
Publikováno v:
Drug Development and Industrial Pharmacy. 21:2151-2165
The effects of the lubricant magnesium stearate at different concentrations, mixing shear rates, and mixing times on the tablet properties and drug dissolution from controlled-release matrix tablets containing hydroxypropyl methylcellulose 2208, USP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e226f887deed8bc3feadbcb1a35df8b6
https://doi.org/10.3109/03639049509065898
https://doi.org/10.3109/03639049509065898
Autor:
Carol Mohler, Jaime L. Curtis-Fisk, Paul J. Sheskey, Karen M. Balwinski, Karen A. Coppens, Jin Zhao
Publikováno v:
AAPS PharmSciTech. 13(4)
This study investigated the effects of polymer dispersion and hydration conditions on hypromellose (HPMC) film properties, such as strength, oxygen permeability, water vapor transmission, clarity, and haze. The focus of the study was to build a bette
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d64562b13d828a3300f02ef710d7bd
https://pubmed.ncbi.nlm.nih.gov/22961412
https://pubmed.ncbi.nlm.nih.gov/22961412
Publikováno v:
Drug development and industrial pharmacy. 37(12)
The concentration of hypromellose (HPMC) is known to significantly impact the viscosity of coating solutions. The purpose of this study was to determine the viscosity of novel low-molecular-weight (LMW) HPMC products as a function of polymer concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db078416ef3948e3d3e2ea1ba7ee0db2
https://pubmed.ncbi.nlm.nih.gov/21615208
https://pubmed.ncbi.nlm.nih.gov/21615208
Autor:
Colin M. Keary, Paul J. Sheskey
Publikováno v:
Drug development and industrial pharmacy. 30(8)
Spray granulation is commonly used to improve the flow of drug formulation powders by adding liquid binders. We have discovered a new granulation process whereby liquid binders are added as aqueous foam. Initial experiments indicate that foam granula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f573bb39229abcc1e0644e847706539
https://pubmed.ncbi.nlm.nih.gov/15521329
https://pubmed.ncbi.nlm.nih.gov/15521329