Safety, immunological effects and clinical response in a phase I trial of umbilical cord mesenchymal stromal cells in patients with treatment refractory SLE

Autor: Gary Gilkeson, Zihai Li, Megan Wyatt, Paul J Nietert, Hongjun Wang, Chungwen Wei, Bethany J Wolf, Caroline Wallace, Crystal Paulos

Publikováno v: Lupus Science and Medicine, Vol 9, Iss 1 (2022)

Background Reports of clinical improvement following mesenchymal stromal cell (MSC) infusions in refractory lupus patients at a single centre in China led us to perform an explorative phase I trial of umbilical cord derived MSCs in patients refractor

Externí odkaz: https://doaj.org/article/cda34b05de2647adbfa2b68ec8bb83a8

World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions

Autor: Stephen Kaptoge, Lisa Pennells, Dirk De Bacquer, Marie Therese Cooney, Maryam Kavousi, Gretchen Stevens, Leanne Margaret Riley, Stefan Savin, Taskeen Khan, Servet Altay, Philippe Amouyel, Gerd Assmann, Steven Bell, Yoav Ben-Shlomo, Lisa Berkman, Joline W Beulens, Cecilia Björkelund, Michael Blaha, Dan G Blazer, Thomas Bolton, Ruth Bonita Beaglehole, Hermann Brenner, Eric J Brunner, Edoardo Casiglia, Parinya Chamnan, Yeun-Hyang Choi, Rajiv Chowdry, Sean Coady, Carlos J Crespo, Mary Cushman, Gilles R Dagenais, Ralph B D'Agostino Sr, Makoto Daimon, Karina W Davidson, Gunnar Engström, Ian Ford, John Gallacher, Ron T Gansevoort, Thomas Andrew Gaziano, Simona Giampaoli, Greg Grandits, Sameline Grimsgaard, Diederick E Grobbee, Vilmundur Gudnason, Qi Guo, Hanna Tolonen, Steve Humphries, Hiroyasu Iso, J Wouter Jukema, Jussi Kauhanen, Andre Pascal Kengne, Davood Khalili, Wolfgang Koenig, Daan Kromhout, Harlan Krumholz, TH Lam, Gail Laughlin, Alejandro Marín Ibañez, Tom W Meade, Karel G M Moons, Paul J Nietert, Toshiharu Ninomiya, Børge G Nordestgaard, Christopher O'Donnell, Luigi Palmieri, Anushka Patel, Pablo Perel, Jackie F Price, Rui Providencia, Paul M Ridker, Beatriz Rodriguez, Annika Rosengren, Ronan Roussel, Masaru Sakurai, Veikko Salomaa, Shinichi Sato, Ben Schöttker, Nawar Shara, Jonathan E Shaw, Hee-Choon Shin, Leon A Simons, Eleni Sofianopoulou, Johan Sundström, Henry Völzke, Robert B Wallace, Nicholas J Wareham, Peter Willeit, David Wood, Angela Wood, Dong Zhao, Mark Woodward, Goodarz Danaei, Gregory Roth, Shanthi Mendis, Oyere Onuma, Cherian Varghese, Majid Ezzati, Ian Graham, Rod Jackson, John Danesh, Emanuele Di Angelantonio

Publikováno v: The Lancet Global Health, Vol 7, Iss 10, Pp e1332-e1345 (2019)

Summary: Background: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, valid

Externí odkaz: https://doaj.org/article/cbe6b4445261496287e2ed04c8f32089

Differences in plasma levels of long chain and very long chain ceramides between African Americans and whites: An observational study.

Autor: Joy N Jones Buie, Samar M Hammad, Paul J Nietert, Gayenell Magwood, Robert J Adams, Leonardo Bonilha, Catrina Sims-Robinson

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0216213 (2019)

BackgroundPopulation-wide reductions in cardiovascular disease (CVD) have not been equally shared in the African American community due to a higher burden of CVD risk factors such as metabolic disorders and obesity. Differential concentrations of sph

Externí odkaz: https://doaj.org/article/ad38fffdb08b4777a2f7b0d307169fe8

Master Settlement Agreement (MSA) spending and tobacco control efforts.

Autor: Jayani Jayawardhana, W David Bradford, Walter Jones, Paul J Nietert, Gerard Silvestri

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114706 (2014)

We investigate whether the distributions to the states from the Tobacco Master Settlement Agreement (MSA) in 1998 is associated with stronger tobacco control efforts. We use state level data from 50 states and the District of Columbia from four time

Externí odkaz: https://doaj.org/article/5d29e7343436469d8a4c418ab2aeb0a8

Alpha-1 Antitrypsin Augmentation Therapy in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy and Islet Autotransplantation: A Randomized, Controlled Study

Autor: Hongjun Wang, Wenyu Gou, Paul J. Nietert, Jason Hirsch, Jingjing Wang, Ahmed Allawi, Abd S. Mortadha, Kelsey Cook, Morgan Overstreet, Hua Wei, David Adams, William P. Lancaster, Katherine A. Morgan, Charlie Strange

Publikováno v: Cell Transplantation, Vol 33 (2024)

Stress-induced islet graft loss during the peri-transplantation period reduces the efficacy of islet transplantation. In this prospective, randomized, double-blind clinical trial, we evaluated the safety and efficacy of 60 mg/kg human alpha-1 antitry

Externí odkaz: https://doaj.org/article/8d37e1ad0a6044cf9365247481997e32