Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Paul J McLaren"'
Autor:
Mariana Herrera, Yoav Keynan, Paul J McLaren, Juan Pablo Isaza, Bernard Abrenica, Lucelly López, Diana Marin, Zulma Vanessa Rueda
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274257 (2022)
ObjectiveTo determine the gene expression profile in individuals with new latent tuberculosis infection (LTBI), and to compare them with people with active tuberculosis (TB) and those exposed to TB but not infected.DesignA prospective cohort study. R
Externí odkaz:
https://doaj.org/article/fd5661fce36f4983ad83fa9d5f407295
Autor:
István Bartha, Paul J McLaren, Chanson Brumme, Richard Harrigan, Amalio Telenti, Jacques Fellay
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005339 (2017)
We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the
Externí odkaz:
https://doaj.org/article/ea5b8b00e9bd493e91d0905ad4831905
Autor:
István Bartha, Antonio Rausell, Paul J McLaren, Pejman Mohammadi, Manuel Tardaguila, Nimisha Chaturvedi, Jacques Fellay, Amalio Telenti
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 12, p e1004647 (2015)
Sequencing projects have identified large numbers of rare stop-gain and frameshift variants in the human genome. As most of these are observed in the heterozygous state, they test a gene's tolerance to haploinsufficiency and dominant loss of function
Externí odkaz:
https://doaj.org/article/a87d8d9c22c14ea5b4369f6d02176572
Autor:
Roland R Regoes, Paul J McLaren, Manuel Battegay, Enos Bernasconi, Alexandra Calmy, Huldrych F Günthard, Matthias Hoffmann, Andri Rauch, Amalio Telenti, Jacques Fellay, Swiss HIV Cohort Study
Publikováno v:
PLoS Biology, Vol 12, Iss 9, p e1001951 (2014)
In ecology, "disease tolerance" is defined as an evolutionary strategy of hosts against pathogens, characterized by reduced or absent pathogenesis despite high pathogen load. To our knowledge, tolerance has to date not been quantified and disentangle
Externí odkaz:
https://doaj.org/article/d417dc8d987444de8991a39ce1147a0b
Autor:
Antonio Rausell, Pejman Mohammadi, Paul J McLaren, Istvan Bartha, Ioannis Xenarios, Jacques Fellay, Amalio Telenti
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 7, p e1003757 (2014)
Loss-of-function variants in innate immunity genes are associated with Mendelian disorders in the form of primary immunodeficiencies. Recent resequencing projects report that stop-gains and frameshifts are collectively prevalent in humans and could b
Externí odkaz:
https://doaj.org/article/7d73418f899b4c33a120716f496a84b9
Autor:
Nuria Izquierdo-Useros, Maier Lorizate, Paul J McLaren, Amalio Telenti, Hans-Georg Kräusslich, Javier Martinez-Picado
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004146 (2014)
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture
Externí odkaz:
https://doaj.org/article/938f612e35424ab6a5e61426924a8881
Autor:
Dominique L Braun, Roger Kouyos, Corinna Oberle, Christina Grube, Beda Joos, Jacques Fellay, Paul J McLaren, Herbert Kuster, Huldrych F Günthard
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114111 (2014)
Best long-term practice in primary HIV-1 infection (PHI) remains unknown for the individual. A risk-based scoring system associated with surrogate markers of HIV-1 disease progression could be helpful to stratify patients with PHI at highest risk for
Externí odkaz:
https://doaj.org/article/d98d8af9798b4fd291b9c7179236333d
Autor:
István Bartha, Jonathan M Carlson, Chanson J Brumme, Paul J McLaren, Zabrina L Brumme, Mina John, David W Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J O’Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M Allen, Viktor Müller, P Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay, for the HIV Genome-to-Genome Study and the Swiss HIV Cohort Study
Publikováno v:
eLife, Vol 2 (2013)
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 seq
Externí odkaz:
https://doaj.org/article/5d773a28930442e492f392ab859e9ef9
Autor:
Paul J McLaren, Cédric Coulonges, Stephan Ripke, Leonard van den Berg, Susan Buchbinder, Mary Carrington, Andrea Cossarizza, Judith Dalmau, Steven G Deeks, Olivier Delaneau, Andrea De Luca, James J Goedert, David Haas, Joshua T Herbeck, Sekar Kathiresan, Gregory D Kirk, Olivier Lambotte, Ma Luo, Simon Mallal, Daniëlle van Manen, Javier Martinez-Picado, Laurence Meyer, José M Miro, James I Mullins, Niels Obel, Stephen J O'Brien, Florencia Pereyra, Francis A Plummer, Guido Poli, Ying Qi, Pierre Rucart, Manj S Sandhu, Patrick R Shea, Hanneke Schuitemaker, Ioannis Theodorou, Fredrik Vannberg, Jan Veldink, Bruce D Walker, Amy Weintrob, Cheryl A Winkler, Steven Wolinsky, Amalio Telenti, David B Goldstein, Paul I W de Bakker, Jean-François Zagury, Jacques Fellay
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003515 (2013)
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure
Externí odkaz:
https://doaj.org/article/8b487ebc53ca4a4eae671f4a5970e634
Autor:
Shengping Li, Ji Qian, Yuan Yang, Wanting Zhao, Juncheng Dai, Jin-Xin Bei, Jia Nee Foo, Paul J McLaren, Zhiqiang Li, Jingmin Yang, Feng Shen, Li Liu, Jiamei Yang, Shuhong Li, Shandong Pan, Yi Wang, Wenjin Li, Xiangjun Zhai, Boping Zhou, Lehua Shi, Xinchun Chen, Minjie Chu, Yiqun Yan, Jun Wang, Shuqun Cheng, Jiawei Shen, Weihua Jia, Jibin Liu, Jiahe Yang, Zujia Wen, Aijun Li, Ying Zhang, Guoliang Zhang, Xianrong Luo, Hongbo Qin, Minshan Chen, Hua Wang, Li Jin, Dongxin Lin, Hongbing Shen, Lin He, Paul I W de Bakker, Hongyang Wang, Yi-Xin Zeng, Mengchao Wu, Zhibin Hu, Yongyong Shi, Jianjun Liu, Weiping Zhou
Publikováno v:
PLoS Genetics, Vol 8, Iss 7, p e1002791 (2012)
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). To further identify novel susceptibility loci associated with HBV-related HCC and replic
Externí odkaz:
https://doaj.org/article/422907c746d84f9cae6b6c434e88d758