Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Paul J Kostenuik"'
Autor:
Ifaz T. Haider, Lindsay L. Loundagin, Andrew Sawatsky, Paul J. Kostenuik, Steven K. Boyd, W. Brent Edwards
Publikováno v:
Journal of Bone and Mineral Research. 38:403-413
Prolonged use of antiresorptives like the bisphosphonate alendronate (ALN) and the RANKL inhibitor denosumab (DMAb) are associated with rare cases of atypical femoral fracture (AFF). The etiology of AFF is unclear, but it has been hypothesized that p
Autor:
Monica Florio, Paul J. Kostenuik, Marina Stolina, Franklin J. Asuncion, Mario Grisanti, Hua Zhu Ke, Michael S. Ominsky
Publikováno v:
Journal of Bone and Joint Surgery.
Autor:
Carmen Streicher, Alexandra Heyny, Olena Andrukhova, Barbara Haigl, Svetlana Slavic, Christiane Schüler, Karoline Kollmann, Ingrid Kantner, Veronika Sexl, Miriam Kleiter, Lorenz C. Hofbauer, Paul J. Kostenuik, Reinhold G. Erben
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produce
Externí odkaz:
https://doaj.org/article/8deacb25c8e6455ab90cd1d806872bfd
Autor:
Felicitas Beck, Eliza S. Hartmann, Miriam I. Koehler, Julia I. Redeker, Sabine Schluessel, Baerbel Schmitt, Andreas Fottner, Marina Unger, Martijn van Griensven, Jan Michael, Burkhard Summer, Karl-Heinz Kunzelmann, Rene Beutner, Dieter Scharnweber, Paul J. Kostenuik, Susanne Mayer-Wagner
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1002 (2019)
Immobilization of proteins has been examined to improve implant surfaces. In this study, titanium surfaces were modified with nanofunctionalized denosumab (cDMAB), a human monoclonal anti-RANKL IgG. Noncoding DNA oligonucleotides (ODN) served as link
Externí odkaz:
https://doaj.org/article/490825e20ca841d6bf77ccb5dad06324
Autor:
William V. Giannobile, Frederic Kauffmann, Paul J. Kostenuik, Gill Holdsworth, Yao Yao, Lea Sarment, Shogo Maekawa, Edward J. Doherty, James V. Sugai, Caroline A. Schmiedeler
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Destruction of the alveolar bone in the jaws can occur due to periodontitis, trauma or following tumor resection. Common reconstructive therapy can include the use of bone grafts with limited predictability and efficacy. Romosozumab, approved by the
Autor:
Ifaz T, Haider, Andrew, Sawatsky, Ying, Zhu, Rebecca, Page, Paul J, Kostenuik, Steven K, Boyd, W Brent, Edwards
Publikováno v:
SSRN Electronic Journal.
Upper extremity fractures, including those at the humerus, are common among women with postmenopausal osteoporosis. Denosumab was shown to reduce humeral fractures in this population; however, no clinical or preclinical studies have quantified the ef
Autor:
Allen Pierce, Heidi Chandler, Michael S. Ominsky, Jeffery Brown, Beate Lanske, Gary Hattersley, Paul J. Kostenuik
Publikováno v:
Journal of Orthopaedic Research. 37:812-820
Fractures typically heal via endochondral and intramembranous bone formation, which together form a callus that achieves union and biomechanical recovery. PTHrP, a PTH receptor agonist, plays an important physiological role in fracture healing as an
Autor:
Jeffrey L. Brown, Aurore Varela, Bruce H. Mitlak, Marilyne Boyer, Paul J. Kostenuik, Allen Pierce, Martin Guillot, Beate Lanske, Heidi Chandler, Gary Hattersley, Roland Baron, Michael S. Ominsky
Publikováno v:
Bone. 120:148-155
Male osteoporosis can occur with advanced age and with hypogonadism, with increased bone resorption and/or inadequate bone formation contributing to reduced bone mass and increased fracture risk. Abaloparatide is a selective PTH receptor agonist that
Autor:
Sundeep Khosla, Susan L. Greenspan, Paul J Kostenuik, Paul D. Miller, John P. Bilezikian, E. Michael Lewiecki, Lora Giangregorio, Roberto Pacifici, Kelly Krohn, Michael R. McClung
Publikováno v:
Journal of Clinical Densitometry. 22:1-19
The Santa Fe Bone Symposium is an annual meeting devoted to clinical applications of recent advances in skeletal research. The 19th Santa Fe Bone Symposium convened August 3–4, 2018, in Santa Fe, New Mexico, USA. Attendees included physicians of ma
Autor:
Yao, Yao, Frederic, Kauffmann, Shogo, Maekawa, Lea V, Sarment, James V, Sugai, Caroline A, Schmiedeler, Edward J, Doherty, Gill, Holdsworth, Paul J, Kostenuik, William V, Giannobile
Publikováno v:
Scientific reports. 10(1)
Destruction of the alveolar bone in the jaws can occur due to periodontitis, trauma or following tumor resection. Common reconstructive therapy can include the use of bone grafts with limited predictability and efficacy. Romosozumab, approved by the