Zobrazeno 1 - 10
of 315
pro vyhledávání: '"Paul J Hertzog"'
Autor:
Jemma R Mayall, Jay C Horvat, Niamh E Mangan, Anne Chevalier, Huw McCarthy, Daniel Hampsey, Chantal Donovan, Alexandra C Brown, Antony Y Matthews, Nicole A de Weerd, Eveline D de Geus, Malcolm R Starkey, Richard Y Kim, Katie Daly, Bridie J Goggins, Simon Keely, Steven Maltby, Rennay Baldwin, Paul S Foster, Michael J Boyle, Pradeep S Tanwar, Nicholas D Huntington, Paul J Hertzog, Philip M Hansbro
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 2, Pp 267-293 (2024)
Abstract The uterus is a unique mucosal site where immune responses are balanced to be permissive of a fetus, yet protective against infections. Regulation of natural killer (NK) cell responses in the uterus during infection is critical, yet no studi
Externí odkaz:
https://doaj.org/article/27c077dad3a5489b8adb434699dbf324
Autor:
Rosa C Coldbeck-Shackley, Ornella Romeo, Sarah Rosli, Linden J Gearing, Jodee A Gould, San S Lim, Kylie H Van der Hoek, Nicholas S Eyre, Byron Shue, Sarah A Robertson, Sonja M Best, Michelle D Tate, Paul J Hertzog, Michael R Beard
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1010843 (2023)
The immunological surveillance factors controlling vulnerability of the female reproductive tract (FRT) to sexually transmitted viral infections are not well understood. Interferon-epsilon (IFNɛ) is a distinct, immunoregulatory type-I IFN that is co
Externí odkaz:
https://doaj.org/article/5466e29dbea44bb9bb2a994a75c3a117
Autor:
Damien J Zanker, Alex J Spurling, Natasha K Brockwell, Katie L Owen, Jasmine M Zakhour, Tina Robinson, Hendrika M Duivenvoorden, Paul J Hertzog, Stefanie R Mullins, Robert W Wilkinson, Belinda S Parker
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 9, Pp n/a-n/a (2020)
Abstract Objectives Loss of tumor‐inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progression via decreased immunogenicity and antitumor immunity. Previous studies in murine models of triple‐negative
Externí odkaz:
https://doaj.org/article/61578605bee846698ae1d74398aee779
Autor:
Linden J Gearing, Helen E Cumming, Ross Chapman, Alexander M Finkel, Isaac B Woodhouse, Kevin Luu, Jodee A Gould, Samuel C Forster, Paul J Hertzog
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0215495 (2019)
The availability of large amounts of high-throughput genomic, transcriptomic and epigenomic data has provided opportunity to understand regulation of the cellular transcriptome with an unprecedented level of detail. As a result, research has advanced
Externí odkaz:
https://doaj.org/article/a018a2d8f027438484eb71d2b5994a33
Autor:
Jane A C Wilson, Natalie A Prow, Wayne A Schroder, Jonathan J Ellis, Helen E Cumming, Linden J Gearing, Yee Suan Poo, Adam Taylor, Paul J Hertzog, Francesca Di Giallonardo, Linda Hueston, Roger Le Grand, Bing Tang, Thuy T Le, Joy Gardner, Suresh Mahalingam, Pierre Roques, Phillip I Bird, Andreas Suhrbier
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006155 (2017)
Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease. Herein we describe a comprehensive RNA-Seq analysis of feet and lymph nodes at peak viraemia (day 2 post infection), acute arthritis (d
Externí odkaz:
https://doaj.org/article/0653401484b34f76b6ecd728f514cfb1
Autor:
Ismail Sebina, Kylie R James, Megan S F Soon, Lily G Fogg, Shannon E Best, Fabian de Labastida Rivera, Marcela Montes de Oca, Fiona H Amante, Bryce S Thomas, Lynette Beattie, Fernando Souza-Fonseca-Guimaraes, Mark J Smyth, Paul J Hertzog, Geoffrey R Hill, Andreas Hutloff, Christian R Engwerda, Ashraful Haque
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005999 (2016)
Parasite-specific antibodies protect against blood-stage Plasmodium infection. However, in malaria-endemic regions, it takes many months for naturally-exposed individuals to develop robust humoral immunity. Explanations for this have focused on antig
Externí odkaz:
https://doaj.org/article/a54be06609244dfbb023d5a998aed957
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Type I interferons (IFNs) are an important family of cytokines that regulate innate and adaptive immune responses to pathogens, in cancer and inflammatory diseases. While the regulation and role of protein-coding genes involved in these responses are
Externí odkaz:
https://doaj.org/article/6d5c496facb743e3b7898c9134723ea8
Autor:
Saleela M Ruwanpura, Louise McLeod, Andrew R Lilja, Gavin Brooks, Lovisa F Dousha, Huei J Seow, Steven Bozinovski, Ross Vlahos, Paul J Hertzog, Gary P Anderson, Brendan J Jenkins
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78095 (2013)
Myeloid differentiation factor 88 (MyD88) and MyD88-adaptor like (Mal)/Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) play a critical role in transducing signals downstream of the Toll-like receptor (TLR) family. While genetic
Externí odkaz:
https://doaj.org/article/408edc3f232048dfacd9bf0d20b96689
Autor:
Wendy J van Zuylen, Valerie Garceau, Adi Idris, Kate Schroder, Katharine M Irvine, Jane E Lattin, Dmitry A Ovchinnikov, Andrew C Perkins, Andrew D Cook, John A Hamilton, Paul J Hertzog, Katryn J Stacey, Stuart Kellie, David A Hume, Matthew J Sweet
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15723 (2011)
BackgroundThe ten mouse and six human members of the Schlafen (Slfn) gene family all contain an AAA domain. Little is known of their function, but previous studies suggest roles in immune cell development. In this report, we assessed Slfn regulation
Externí odkaz:
https://doaj.org/article/0e772b52cc8148969f6d70d48c2a29ad
Autor:
Daniel J Gough, Nicole L Messina, Linda Hii, Jodee A Gould, Kanaga Sabapathy, Ashley P S Robertson, Joseph A Trapani, David E Levy, Paul J Hertzog, Christopher J P Clarke, Ricky W Johnstone
Publikováno v:
PLoS Biology, Vol 8, Iss 4, p e1000361 (2010)
Autocrine priming of cells by small quantities of constitutively produced type I interferon (IFN) is a well-known phenomenon. In the absence of type I IFN priming, cells display attenuated responses to other cytokines, such as anti-viral protection i
Externí odkaz:
https://doaj.org/article/534b147fa2ff4ed686a5638eb2e548af