Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Paul J Grippo"'
Autor:
Megha Singhal, Mahsa Khatibeghdami, Daniel R Principe, Georgina E Mancinelli, Kyle M Schachtschneider, Lawrence B Schook, Paul J Grippo, Sam R Grimaldo
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0211711 (2019)
Current therapies for pancreatic ductal adenocarcinoma (PDAC) only modestly impact survival and can be highly toxic. A greater understanding of the molecules regulating this disease is critical for identifying new drug targets and developing more eff
Externí odkaz:
https://doaj.org/article/55f1db67793741ae944612964f9e2a33
Autor:
Elias Gounaris, Michael J Heiferman, Jeffrey R Heiferman, Manisha Shrivastav, Dominic Vitello, Nichole R Blatner, Lawrence M Knab, Joseph D Phillips, Eric C Cheon, Paul J Grippo, Khashayarsha Khazaie, Hidayatullah G Munshi, David J Bentrem
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121402 (2015)
Leukotrienes and prostaglandins, products of arachidonic acid metabolism, sustain both systemic and lesion-localized inflammation. Tumor-associated Inflammation can also contribute to the pathogenesis of colon cancer. Patients with inflammatory bowel
Externí odkaz:
https://doaj.org/article/270e5324d5dd43e89ec58fc40eb92a62
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
The study of pancreatic cancer has prompted the development of numerous mouse models that aim to recapitulate the phenotypic and mechanistic features of this deadly malignancy. This review accomplishes two tasks. First, it provides an overview of the
Externí odkaz:
https://doaj.org/article/344459dd376541a590c5e371cdc24824
Autor:
Mark B. Wiley, Jessica Bauer, Kunaal Mehrotra, Jasmin Zessner-Spitzenberg, Zoe Kolics, Wenxuan Cheng, Karla Castellanos, Michael G. Nash, Xianyong Gui, Lyonell Kone, Ajay V. Maker, Guilin Qiao, Deepti Reddi, David N. Church, Rachel S. Kerr, David J. Kerr, Paul J. Grippo, Barbara Jung
Publikováno v:
Cancers, Vol 15, Iss 11, p 3003 (2023)
We have shown that activin A (activin), a TGF-β superfamily member, has pro-metastatic effects in colorectal cancer (CRC). In lung cancer, activin activates pro-metastatic pathways to enhance tumor cell survival and migration while augmenting CD4+ t
Externí odkaz:
https://doaj.org/article/72f8a1a77888447689c7b01216093d92
Autor:
Hidayatullah G. Munshi, Paul J. Grippo, David J. Bentrem, Krishan Kumar, Akash P. Patel, Vaibhav Sahai, Sania S. Raza, Christina R. Chow, Kazumi Ebine, Lawrence M. Knab
Supplementary Figure S1 - Effect of pancreatitis on mast cell infiltration. Supplementary Figure S2 - Snail expression in CD18 cells. Supplementary Figure S3 - Slug expression in AsPC1 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434efe43df5349104acb0c57fd932295
https://doi.org/10.1158/1541-7786.22514514
https://doi.org/10.1158/1541-7786.22514514
Autor:
Ajay Rana, Paul J. Grippo, Hidayatullah G. Munshi, Ronald McKinney, Carolina Torres, Jonathan Rubin, Navin Viswakarma, Sandeep Kumar, Matthew J. Dorman, Alex Park, Daniel R. Principe
Figure S1 shows that T-cell deficiency of TGFBR1 promotes an immune response against established pancreatic neoplasms. Interestingly, this was not recapitulated via systemic reduction of TGFBR1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06554333f77a4e2010b1adc8862823bb
https://doi.org/10.1158/1535-7163.22505817.v1
https://doi.org/10.1158/1535-7163.22505817.v1
Autor:
Hidayatullah G. Munshi, David J. Bentrem, Paul J. Grippo, M. Sambasiva Rao, Rosa F. Hwang, Morgan R. Barron, Eric C. Cheon, Surabhi Dangi-Garimella, Mario A. Shields, Seth B. Krantz
Pancreatic cancer is associated with a pronounced fibrotic reaction that was recently shown to limit delivery of chemotherapy. To identify potential therapeutic targets to overcome this fibrosis, we examined the interplay between fibrosis and the key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cc7528a58dd8fab45c3964ea2fd3d8
https://doi.org/10.1158/1541-7786.c.6542107
https://doi.org/10.1158/1541-7786.c.6542107
Autor:
Hidayatullah G. Munshi, David J. Bentrem, Paul J. Grippo, M. Sambasiva Rao, Rosa F. Hwang, Morgan R. Barron, Eric C. Cheon, Surabhi Dangi-Garimella, Mario A. Shields, Seth B. Krantz
PDF File (6111K)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9361cf7a51911d8626ba0eb9118eb202
https://doi.org/10.1158/1541-7786.22518745
https://doi.org/10.1158/1541-7786.22518745
Autor:
Ajay Rana, Paul J. Grippo, Hidayatullah G. Munshi, Ronald McKinney, Carolina Torres, Jonathan Rubin, Navin Viswakarma, Sandeep Kumar, Matthew J. Dorman, Alex Park, Daniel R. Principe
Pancreatic ductal adenocarcinoma (PDAC) remains remarkably lethal with a 5-year survival rate of 8%. This is mainly attributed to the late stage of presentation, as well as widespread resistance to conventional therapy. In addition, PDAC tumors are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d677048e550cb2909525bd646316a731
https://doi.org/10.1158/1535-7163.c.6538185.v1
https://doi.org/10.1158/1535-7163.c.6538185.v1
Autor:
Paul J. Grippo, Barbara Jung, Hidayatullah G. Munshi, David J. Bentrem, Deyu Fang, David W. Dawson, Boris Pasche, Rosa Hwang, Naomi Akagi, Andrew M. Diaz, Elizabeth A. Wayne, Emman Mascariñas, Brian DeCant, Daniel R. Principe
Figure S6. Global TGFBR-Deficiency does not Alter Non-Peripheral Tregs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0048aca13df700f66e9f2843438082f5
https://doi.org/10.1158/0008-5472.22411965.v1
https://doi.org/10.1158/0008-5472.22411965.v1