Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Paul J Fitzgerald"'
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215554 (2019)
Major depression is a stress-linked disease with significant morbidity and the anesthetic drug ketamine is of growing interest in the treatment of depression, since in responsive individuals a single dose has rapid (within hours) antidepressant effec
Externí odkaz:
https://doaj.org/article/16fac2738b3d420ca514184aa6f50fa5
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165256 (2016)
The medial prefrontal cortex (mPFC) plays a crucial role in emotional learning and memory in rodents and humans. While many studies suggest a differential role for the prelimbic (PL) and infralimbic (IL) subdivisions of mPFC, few have considered the
Externí odkaz:
https://doaj.org/article/1798131d59f443ffad96c8091e8772b8
Autor:
Paul J Fitzgerald
Publikováno v:
Clinical Epidemiology, Vol 2010, Iss default, Pp 1-3 (2009)
Paul J FitzgeraldThe Zanvyl Krieger Mind/Brain Institute, Solomon H. Snyder, Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USAAbstract: Recently, I put forth the hypothesis that the signaling molecule, norepinephrine (NE), is a
Externí odkaz:
https://doaj.org/article/755d463e649a4010b22fd13938286f2e
Autor:
Brendon O. Watson, Joanna L. Spencer-Segal, Paul J. Fitzgerald, Ali Gheidi, Jonathan D. Morrow, Savannah K Kounelis-Wuillaume
Publikováno v:
Stress
Ketamine has emerged as a novel treatment for common psychiatric conditions such as Major Depressive Disorder (MDD) and anxiety disorders, many of which can be initiated and exacerbated by psychological stress. Sex differences in the frequency of bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264e2896cc55bf9579e3bd6769ce573c
https://doi.org/10.1080/10253890.2021.1871600
https://doi.org/10.1080/10253890.2021.1871600
Autor:
Paul J. Fitzgerald
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience
Major depressive disorder (MDD) remains a significant public health problem worldwide, and revised treatment strategies are therefore urgently needed, including the creation of novel antidepressant compounds or using existing molecular entities in ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab73b1220811ef46b23d3a32619b762e
https://www.frontiersin.org/articles/10.3389/fnbeh.2021.673634/full
https://www.frontiersin.org/articles/10.3389/fnbeh.2021.673634/full
Autor:
Brendon O. Watson, Paul J. Fitzgerald
Publikováno v:
Experimental Brain Research
Antidepressant drugs are a standard biological treatment for various neuropsychiatric disorders, yet relatively little is known about their electrophysiologic and synaptic effects on mood systems that set moment-to-moment emotional tone. In vivo elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5fc9d9febd0eb5490e91e19b0be84b
https://doi.org/10.1007/s00221-019-05556-5
https://doi.org/10.1007/s00221-019-05556-5
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fear relapse represents a significant problem for individuals suffering from stress- and trauma-related disorders such as posttraumatic stress disorder. Here, we show that locus coeruleus norepinephrine activation produces fear relapse i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cebe5d98a575bc92a02f5f577b36e97
http://europepmc.org/articles/PMC6486780
http://europepmc.org/articles/PMC6486780
Autor:
Paul J. Fitzgerald
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7364, p 7364 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
While much of biomedical research since the middle of the twentieth century has focused on molecular pathways inside the cell, there is increasing evidence that extracellular signaling pathways are also critically important in health and disease. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d03340b8ec650f29ebe97706781a20
https://www.mdpi.com/1422-0067/22/14/7364
https://www.mdpi.com/1422-0067/22/14/7364
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Frontiers in Psychiatry
Frontiers in Psychiatry
The anesthetic drug ketamine has been successfully repurposed as an antidepressant in human subjects. This represents a breakthrough for clinical psychopharmacology, because unlike monoaminergic antidepressants, ketamine has rapid onset, including in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93823bc1a744a1ab721a7b13c931a0ef
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.659052/full
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.659052/full
Autor:
Paul J. Fitzgerald
Publikováno v:
Acta Neurologica Scandinavica. 145:3-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234af580a9bac6952d4feb373ebde848
https://doi.org/10.1111/ane.13526
https://doi.org/10.1111/ane.13526