Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Paul J Cullen"'
Autor:
Anil Kumar Vijjamarri, Xiao Niu, Matthew D Vandermeulen, Chisom Onu, Fan Zhang, Hongfang Qiu, Neha Gupta, Swati Gaikwad, Miriam L Greenberg, Paul J Cullen, Zhenguo Lin, Alan G Hinnebusch
Publikováno v:
eLife, Vol 12 (2023)
Degradation of most yeast mRNAs involves decapping by Dcp1/Dcp2. DEAD-box protein Dhh1 has been implicated as an activator of decapping, in coupling codon non-optimality to enhanced degradation, and as a translational repressor, but its functions in
Externí odkaz:
https://doaj.org/article/aa2f0c85f238450c866b4e82f7ac3f97
Autor:
Matthew D Vandermeulen, Paul J Cullen
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1009988 (2022)
Phenotypes can change during exposure to different environments through the regulation of signaling pathways that operate in integrated networks. How signaling networks produce different phenotypes in different settings is not fully understood. Here,
Externí odkaz:
https://doaj.org/article/71682d6a8a8b4cc5a885a619a13a5550
Autor:
Kaitlyn L Norman, Christian A Shively, Amberlene J De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J Cullen, Anuj Kumar
Publikováno v:
PLoS Genetics, Vol 14, Iss 6, p e1007493 (2018)
Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required for virulence in pathogenic fungi and provides an informative model of stress-res
Externí odkaz:
https://doaj.org/article/e2caf8690e2748e49d4a6deed4a703f1
Autor:
Carol A Woolford, Katherine Lagree, Wenjie Xu, Tatyana Aleynikov, Hema Adhikari, Hiram Sanchez, Paul J Cullen, Frederick Lanni, David R Andes, Aaron P Mitchell
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006487 (2016)
Biofilm formation on implanted medical devices is a major source of lethal invasive infection by Candida albicans. Filamentous growth of this fungus is tied to biofilm formation because many filamentation-associated genes are required for surface adh
Externí odkaz:
https://doaj.org/article/8096b2aeb554429d8841b6f3f370ea8c
Metabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway.
Autor:
Hema Adhikari, Paul J Cullen
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004734 (2014)
Evolutionarily conserved mitogen activated protein kinase (MAPK) pathways regulate the response to stress as well as cell differentiation. In Saccharomyces cerevisiae, growth in non-preferred carbon sources (like galactose) induces differentiation to
Externí odkaz:
https://doaj.org/article/2bf53b9af8444232953d433c6e764612
Autor:
Sumant Puri, Rohitashw Kumar, Sonia Chadha, Swetha Tati, Heather R Conti, Bernhard Hube, Paul J Cullen, Mira Edgerton
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e46020 (2012)
Perception of external stimuli and generation of an appropriate response are crucial for host colonization by pathogens. In pathogenic fungi, mitogen activated protein kinase (MAPK) pathways regulate dimorphism, biofilm/mat formation, and virulence.
Externí odkaz:
https://doaj.org/article/5344aa66891b4c73bd4fcae60b60c918
Autor:
Sheelarani Karunanithi, Jyoti Joshi, Colin Chavel, Barbara Birkaya, Laura Grell, Paul J Cullen
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e32294 (2012)
Fungal species exhibit diverse behaviors when presented with extracellular challenges. Pathogenic fungi can undergo cell differentiation and biofilm formation in response to fluctuating nutrient levels, and these responses are required for virulence.
Externí odkaz:
https://doaj.org/article/24853dc7670c4b0083e6b761de84a99c
Publikováno v:
PLoS Genetics, Vol 6, Iss 3, p e1000883 (2010)
An important emerging question in the area of signal transduction is how information from different pathways becomes integrated into a highly coordinated response. In budding yeast, multiple pathways regulate filamentous growth, a complex differentia
Externí odkaz:
https://doaj.org/article/c9333dbd7b4e4b27b5af1a4dd1e8f87c
Publikováno v:
Molecular and Cellular Biology. 43:200-222
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f2c1bc44423b0e1bdbcbab2ca7e26b
https://doi.org/10.1080/10985549.2023.2198171
https://doi.org/10.1080/10985549.2023.2198171
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT Candida albicans is an opportunistic, dimorphic fungus that causes candidiasis in immunocompromised people. C. albicans forms specialized structures called microcolonies that are important for surface adhesion and virulence. Microcolonies fo
Externí odkaz:
https://doaj.org/article/2b1aaa20ace7405ba35b889a51f4da65