Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Paul J Conroy"'
Autor:
Sarah Gilgunn, Silvia Millán Martín, Mark R Wormald, Julia Zapatero-Rodríguez, Paul J Conroy, Richard J O'Kennedy, Pauline M Rudd, Radka Saldova
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159859 (2016)
Recent exploitation of the avian immune system has highlighted its suitability for the generation of high-quality, high-affinity antibodies to a wide range of antigens for a number of therapeutic and biotechnological applications. The glycosylation p
Externí odkaz:
https://doaj.org/article/bce45fb658ad4471830e7848741478d6
Autor:
Adam J. Quek, Nathan P. Cowieson, Tom T. Caradoc-Davies, Paul J. Conroy, James C. Whisstock, Ruby H. P. Law
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14258 (2023)
Plasminogen (Plg) is the inactive form of plasmin (Plm) that exists in two major glycoforms, referred to as glycoforms I and II (GI and GII). In the circulation, Plg assumes an activation-resistant “closed” conformation via interdomain interactio
Externí odkaz:
https://doaj.org/article/0e25f129ee1a4bb79ced86f7bdf462b2
Autor:
Ruby H.P. Law, Guojie Wu, Eleanor W.W. Leung, Koushi Hidaka, Adam J. Quek, Tom T. Caradoc-Davies, Devadharshini Jeevarajah, Paul J. Conroy, Nigel M. Kirby, Raymond S. Norton, Yuko Tsuda, James C. Whisstock
Publikováno v:
Blood Advances, Vol 1, Iss 12, Pp 766-771 (2017)
Abstract: The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation of the plasminogen/plasmin system results in life-threate
Externí odkaz:
https://doaj.org/article/b3a0c868cfc44aa795c55be0ba7c2b58
Autor:
Sarah Gilgunn, Keefe Murphy, Henning Stöckmann, Paul J. Conroy, T. Brendan Murphy, R. William Watson, Richard J. O’Kennedy, Pauline M. Rudd, Radka Saldova
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9233 (2020)
The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly
Externí odkaz:
https://doaj.org/article/7155eeefe8874555b8a6201e91bab4c8
Autor:
Christoph Krisp, Carmen Sonntag, L. Hersey, A.J. Wood, Sara Gibertini, Alex J. Fulcher, Patricia R. Jusuf, A. Siegel, Marina Mora, Chi-Hung Lin, Peter D. Currie, Stefanie Dudczig, Sara Alaei, Nicolle H. Packer, M. Li, K. Nishtala, Lee B. Miles, Paul J. Conroy, Fernando J. Rossello
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
The muscular dystrophies encompass a broad range of pathologies with varied clinical outcomes. In the case of patients carrying defects in fukutin-related protein (FKRP), these diverse pathologies arise from mutations within the same gene. This is su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cabdaabec93cd531c0cf30e6b95309
https://doaj.org/article/5e6f8208fa384dfab7d8162c046eec48
https://doaj.org/article/5e6f8208fa384dfab7d8162c046eec48
Autor:
Paul J. Conroy, Kamil A. Sokolowski, Simon Puttick, S. John Weroha, Thomas Kryza, James C. Whisstock, Brittney S. Harrington, Samantha J. Stehbens, Paul Haluska, T. Cuda, Rohan Lourie, Sarah Reed, Brian W.C. Tse, Buddhika J. Arachchige, Lewis Perrin, Yaowu He, Tashbib Khan, Katherine K. Robbins, Ruby H. P. Law, Carlos Salomon, Pamela M. Pollock, John D. Hooper
Publikováno v:
Theranostics
CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface protein that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2. Its potential as a cancer target is supported by studies showing that anti-CDCP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bb66f483397ea45c9da3d3be260720
https://doi.org/10.7150/thno.30736
https://doi.org/10.7150/thno.30736
Autor:
Phillip I. Bird, Bart W. Hoogenboom, Adrian W. Hodel, Georg Ramm, Susan M. Ekkel, Hariprasad Venugopal, Charles Bayly-Jones, Mazdak Radjainia, Ilia Voskoboinik, Ruby H. P. Law, Paul J. Conroy, Yann Gambin, Siew Siew Pang, Michelle A. Dunstone, Emma Sierecki, Bradley A. Spicer, Edward S. Parsons, James C. Whisstock
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought to form pores in target membranes, however, its mode of action remains unknown. We use cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d562c790b77ea9ee8829a74700201af
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe
Autor:
Malkit Sami, Ben de Wet, Elizabeth A. Potter, Rory M. Crean, Katy A. Lloyd, Velupillai Srikannathasan, Nikolai Lissin, Milos Aleksic, Anitha Jeyanthan, Miriam Hock, David K. Cole, Peter Eamon Molloy, Pierre J. Rizkallah, Marco Lepore, Annelise Vuidepot, Christopher J. Holland, Brian Cameron, Thomas Blicher, Robert J. Pengelly, Christopher R. Pudney, Ross A. Robinson, Johanne M. Pentier, Thomas E. Spinner, Marc W. van der Kamp, Bent K. Jakobsen, Nathaniel Liddy, Paul J. Conroy, Stephen Harper, Angharad Lloyd
Publikováno v:
J Clin Invest
Tumor-associated peptide-human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface-expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbe9e3e9f83c5de1920113bed8d5316
https://europepmc.org/articles/PMC7190993/
https://europepmc.org/articles/PMC7190993/
Publikováno v:
Seminars in Cell & Developmental Biology. 72:117-123
Cytotoxic lymphocytes play a key role in immune homeostasis through elimination of virally-infected and transformed target cells. They do this by employing the potent pore-forming protein, perforin, a molecule that permits cytotoxic proteases, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dec2373fe0c8f1c9a45aafa970e9a1e
https://doi.org/10.1016/j.semcdb.2017.07.033
https://doi.org/10.1016/j.semcdb.2017.07.033
Autor:
James C. Whisstock, Tom T. Caradoc-Davies, Yuko Tsuda, Koushi Hidaka, Raymond S. Norton, Paul J. Conroy, Eleanor W. W. Leung, Guojie Wu, Nigel Kirby, Adam J. Quek, Ruby H. P. Law, Devadharshini Jeevarajah
Publikováno v:
Blood Advances. 1:766-771
The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation of the plasminogen/plasmin system results in life-threatening hemor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f5b271fadfcf104b82665ca06061c1
https://doi.org/10.1182/bloodadvances.2016004150
https://doi.org/10.1182/bloodadvances.2016004150