Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Paul J Cockle"'
Autor:
Adam O Whelan, Michael Coad, Paul J Cockle, Glyn Hewinson, Martin Vordermeier, Stephen V Gordon
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8527 (2010)
Experiments in the late 19th century sought to define the host specificity of the causative agents of tuberculosis in mammals. Mycobacterium tuberculosis, the human tubercle bacillus, was independently shown by Smith, Koch, and von Behring to be avir
Externí odkaz:
https://doaj.org/article/9e9ff2ec38b347799e2c42e42465a8ed
Autor:
Karen E. Logan, R. Glyn Hewinson, Paul J. Cockle, Javier Nunez, Stephen V. Gordon, Jason Hinds, Philip J. Hogarth, Paul Golby, H. Martin Vordermeier, Katie J. Ewer
Publikováno v:
ResearcherID
Genome sequencing of Mycobacterium tuberculosis complex members has accelerated the search for new disease-control tools. Antigen mining is one area that has benefited enormously from access to genome data. As part of an ongoing antigen mining progra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878f3b644c961107e5b8f00f37cb9072
https://doi.org/10.1099/mic.0.2007/014548-0
https://doi.org/10.1099/mic.0.2007/014548-0
Publikováno v:
Clinical and Vaccine Immunology. 13:1119-1124
In the search for improved tools with which to control bovine tuberculosis, the development of enhanced immunodiagnostic reagents is a high priority. Such reagents are required to improve the performance of tuberculin-based reagents and allow the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3dc8c48cba9227305091b054117b3b
https://doi.org/10.1128/cvi.00209-06
https://doi.org/10.1128/cvi.00209-06
Autor:
Marc Govaerts, Karl Walravens, Sylvie Marché, Glyn Hewinson, Steve Gordon, Martin Vordermeier, Katie J. Ewer, Huma Mansoor, Paul J. Cockle
Publikováno v:
Clinical and Vaccine Immunology. 13:90-97
The definition of antigens for the diagnosis of human and bovine tuberculosis is a research priority. If diagnosis is to be used alongside Mycobacterium bovis BCG-based vaccination regimens, it will be necessary to have reagents that allow the discri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd9b80d914f4f129b4d061d4f644b08
https://doi.org/10.1128/cvi.13.1.90-97.2006
https://doi.org/10.1128/cvi.13.1.90-97.2006
Autor:
Adam O. Whelan, H. Martin Vordermeier, R. Glyn Hewinson, Mark A. Chambers, Paul J. Cockle, Jennifer Simmons
Publikováno v:
Infection and Immunity. 70:3026-3032
Vaccine development and the understanding of the pathology of bovine tuberculosis in cattle would be greatly facilitated by the definition of immunological correlates of protection and/or pathology. To address these questions, cattle were vaccinated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca90b6c4d7cd9b19300766fb97b0512d
https://doi.org/10.1128/iai.70.6.3026-3032.2002
https://doi.org/10.1128/iai.70.6.3026-3032.2002
Autor:
M.J. Colston, Paul J. Cockle, Douglas B. Lowrie, Kris Huygen, Shelley G. Rhodes, Mark A. Chambers, Adam O. Whelan, H. M. Vordermeier, Derek Clifford, Ricardo E. Tascon, R. G. Hewinson
Publikováno v:
Vaccine. 19:1246-1255
The current tuberculin test and slaughter strategy for the control of bovine tuberculosis in cattle has failed to prevent a sharp rise in cases over recent years, especially in the south-west of England. A recent scientific review has concluded that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ede0dd30b94cbe8417165d226d78d4a
https://doi.org/10.1016/s0264-410x(00)00238-3
https://doi.org/10.1016/s0264-410x(00)00238-3
Autor:
Paul J. Cockle, Tyler C. Thacker, Adrian V. S. Hill, Zhou Xing, Sarah C. Gilbert, R. Glyn Hewinson, Martin McAulay, H. Martin Vordermeier, Bernardo Villarreal-Ramos, Helen McShane, Shelley G. Rhodes
Previous work with small-animal laboratory models of tuberculosis has shown that vaccination strategies based on heterologous prime-boost protocols using Mycobacterium bovis bacillus Calmette-Guérin (BCG) to prime and modified vaccinia virus Ankara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b933c8b0feceb2c0daa4b4de9be6f507
https://europepmc.org/articles/PMC2715681/
https://europepmc.org/articles/PMC2715681/
Autor:
D. Neil Wedlock, R. Glyn Hewinson, Michel Denis, A.R McCarthy, Bryce M. Buddle, H. Martin Vordermeier, Paul J. Cockle, Natalie A. Parlane
Publikováno v:
Clinical and vaccine immunology : CVI. 14(11)
In this study, we determined if the sensitivity of the currently available in vitro test to detect bovine tuberculosis could be enhanced by adding the following immunomodulators: interleukin-2 (IL-2); granulocyte-macrophage colony-stimulating factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724c75a1c5accc0186357e0a0fbf5d54
https://pubmed.ncbi.nlm.nih.gov/17881504
https://pubmed.ncbi.nlm.nih.gov/17881504
Autor:
Shelley G. Rhodes, Derek Clifford, Michael Coad, G. S. Dean, R. Glyn Hewinson, Adam O. Whelan, H. Martin Vordermeier, Paul J. Cockle
The aim of this work was to determine the minimum infective dose of Mycobacterium bovis necessary to stimulate specific immune responses and generate pathology in cattle. Four groups of calves (20 animals) were infected by the intratracheal route wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f735c8aaa14ceb6df9e3919ceb7cf1c
https://europepmc.org/articles/PMC1230957/
https://europepmc.org/articles/PMC1230957/
Autor:
Rolf Hecker, Mahavir Singh, H. Martin Vordermeier, R. Glyn Hewinson, Paul J. Cockle, Lorne A. Babiuk, Brenda Karvonen, Sylvia van Drunen Littel-van den Hurk, Reno A. Pontarollo
Publikováno v:
Vaccine. 23(35)
Fully synthetic peptide vaccines possess attractive cost and safety attributes. However, peptide vaccines that induce cell-mediated immunity require both selection of appropriate peptides and the development of adjuvant formulations supporting the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6b9ba79b2f48918eb0ef85b7dec2d9
https://pubmed.ncbi.nlm.nih.gov/15908057
https://pubmed.ncbi.nlm.nih.gov/15908057