Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Paul J Caffrey"'
Publikováno v:
Chem Res Toxicol
[Image: see text] 1,N(6)-ethenoadenine (εA) is a mutagenic lesion and biomarker observed in numerous cancerous tissues. Two pathways are responsible for its repair: base excision repair (BER) and direct reversal repair (DRR). Alkyladenine DNA glycos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ee6d0488f53a0d103f41b8d0720d35
https://doi.org/10.1021/acs.chemrestox.0c00089
https://doi.org/10.1021/acs.chemrestox.0c00089
Autor:
Gregory J. S. Lohman, Léa Chuzel, Paul J Caffrey, Samantha L. Fossa, Andrew F. Gardner, Christopher H. Taron, Kelly M Zatopek, Katharina Bilotti, Alexandra M. Gehring
Publikováno v:
Applied and Environmental Microbiology. 88
It has been predicted that 30-80% of archaeal genomes remain annotated as hypothetical proteins with no assigned gene function. Further, many archaeal organisms are difficult to grow or are unculturable. To overcome these technical and experimental h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27adbff95b4f72a3446ea9134c5bf96c
https://doi.org/10.1128/aem.02137-21
https://doi.org/10.1128/aem.02137-21
Autor:
Sarah Delaney, Paul J. Caffrey
Publikováno v:
Biochemistry. 60(3)
A recently discovered post-translational modification of histone proteins is the irreversible proteolytic clipping of the histone N-terminal tail domains. This modification is involved in the regulation of various biological processes, including the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e280457ca77b285400a8a3340614e870
https://pubmed.ncbi.nlm.nih.gov/33426868
https://pubmed.ncbi.nlm.nih.gov/33426868
Publikováno v:
DNA Repair. 71:87-92
The base excision repair (BER) pathway removes modified nucleobases that can be deleterious to an organism. BER is initiated by a glycosylase, which finds and removes these modified nucleobases. Most of the characterization of glycosylase activity ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558b08834bef2610e36305ac5b056f14
https://doi.org/10.1016/j.dnarep.2018.08.011
https://doi.org/10.1016/j.dnarep.2018.08.011
Autor:
Sarah Delaney, Paul J. Caffrey
Publikováno v:
Mutagenesis. 35(1)
DNA is comprised of chemically reactive nucleobases that exist under a constant barrage from damaging agents. Failure to repair chemical modifications to these nucleobases can result in mutations that can cause various diseases, including cancer. For
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0d05ad574a07ba19c233a7eb3dabce
https://pubmed.ncbi.nlm.nih.gov/31612219
https://pubmed.ncbi.nlm.nih.gov/31612219