Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Paul J Bonthuis"'
Autor:
Pranay Bharadwaj, Christine McInnis, Amanda M K Madden, Paul J Bonthuis, Susan Zup, Emilie F Rissman, Jin Ho Park
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69672 (2013)
Male sexual behavior (MSB) is modulated by gonadal steroids, yet this relationship is highly variable across species and between individuals. A significant percentage (~30%) of B6D2F1 hybrid male mice demonstrate MSB after long-term orchidectomy (her
Externí odkaz:
https://doaj.org/article/166f43bae8c642b5a3eb34c2dffd680c
Autor:
Paul J. Bonthuis, Wei-Chao Huang, Cornelia N. Stacher Hörndli, Elliott Ferris, Tong Cheng, Christopher Gregg
Publikováno v:
Cell Reports, Vol 12, Iss 6, Pp 979-991 (2015)
Here, we describe an RNA-sequencing (RNA-seq)-based approach that accurately detects even modest maternal or paternal allele expression biases at the tissue level, which we call noncanonical genomic imprinting effects. We profile imprinting in the ar
Externí odkaz:
https://doaj.org/article/a73cc39bc4e043ac9de2fb1698489876
Autor:
Paul J. Bonthuis, Susan Steinwand, Cornelia N. Stacher Hörndli, Jared Emery, Wei-Chao Huang, Stephanie Kravitz, Elliott Ferris, Christopher Gregg
Publikováno v:
Cell Reports. 38:110500
Noncanonical genomic imprinting can cause biased expression of one parental allele in a tissue; however, the functional relevance of such biases is unclear. To investigate ethological roles for noncanonical imprinting in dopa decarboxylase (Ddc) and
Autor:
Cornelia N. Stacher Hörndli, Jared Emery, Wei-Chao Huang, Elliott Ferris, Stephanie N Kravitz, Susan Steinwand, Paul J Bonthuis, Christopher Gregg
SUMMARYDopa decarboxylase (DDC) regulates the synthesis of monoaminergic neurotransmitters and is linked to psychiatric and metabolic disorders. Ddc exhibits complex genomic imprinting effects that have not been functionally studied. Here, we investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19274352089bdb7951cdf8aa94b96a0d
https://doi.org/10.1101/2020.06.23.168195
https://doi.org/10.1101/2020.06.23.168195
Publikováno v:
Hormones and Behavior. 80:132-138
The importance of gonadal steroids in modulating male sexual behavior is well established. Individual differences in male sexual behavior, independent of gonadal steroids, are prevalent across a wide range of species, including man. However, the gene
Autor:
Tong Cheng, Paul J. Bonthuis, Wei Chao Huang, Elliott Ferris, Christopher Gregg, Cornelia N. Stacher Hörndli
Publikováno v:
Cell Reports, Vol 12, Iss 6, Pp 979-991 (2015)
SummaryHere, we describe an RNA-sequencing (RNA-seq)-based approach that accurately detects even modest maternal or paternal allele expression biases at the tissue level, which we call noncanonical genomic imprinting effects. We profile imprinting in
Autor:
Rolf Turk, Mark A. Behlke, Donald W. Harms, Masato Ohtsuka, Garrett R. Rettig, Christopher Gregg, Rolen M. Quadros, Channabasavaiah B. Gurumurthy, Sarah A. Zeiner, Paul J. Bonthuis, Michael A. Collingwood, Ashley M. Jacobi
Publikováno v:
Methods (San Diego, Calif.)
Genome editing using the CRISPR/Cas9 system requires the presence of guide RNAs bound to the Cas9 endonuclease as a ribonucleoprotein (RNP) complex in cells, which cleaves the host cell genome at sites specified by the guide RNAs. New genetic materia
Autor:
Emilie F. Rissman, Paul J. Bonthuis
Publikováno v:
Endocrinology. 154:3826-3835
As for many human diseases, the incidence of obesity and its associated health risks are sexually dimorphic: worldwide the rate of obesity is higher in women. Sex differences in metabolism, appetite, body composition, and fat deposition are contribut
Publikováno v:
Hormones and Behavior. 61:565-572
Sex differences in the brain and behavior are primarily attributed to dichotomous androgen exposure between males and females during neonatal development, as well as adult responses to gonadal hormones. Here we tested an alternative hypothesis and as
Autor:
Paul J. Bonthuis, Kimberly Cox, Brian T. Searcy, Stuart A. Tobet, P. Kumar, Emilie F. Rissman
Publikováno v:
Frontiers in Neuroendocrinology. 31:341-358
Mice and rats are important mammalian models in biomedical research. In contrast to other biomedical fields, work on sexual differentiation of brain and behavior has traditionally utilized comparative animal models. As mice are gaining in popularity,