Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Paul J, Romaniuk"'
Autor:
Hans-Dieter Royer, Nicole Görldt, Brigitte Royer-Pokora, Paul J. Romaniuk, Stefan G. E. Roberts, Maike Busch, Manfred Beier, Artur Brandt, Heinrich Schwindt, Eneda Toska
Publikováno v:
Human Molecular Genetics
The WT1 gene encodes a zinc finger transcription factor important for normal kidney development. WT1 is a suppressor for Wilms tumour development and an oncogene for diverse malignant tumours. We recently established cell lines from primary Wilms tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8f17e9fc40bd4015035ddc1d69f4e7
https://doi.org/10.1093/hmg/ddu111
https://doi.org/10.1093/hmg/ddu111
Autor:
Paul J, Romaniuk
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1467
Equilibrium binding of WT1 to specific sites in DNA and potentially RNA molecules is central in mediating the regulatory roles of this protein. In order to understand the functional effects of mutations in the nucleic acid-binding domain of WT1 prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::113b9fd376fd993c8fcc7eecea181779
https://pubmed.ncbi.nlm.nih.gov/27417968
https://pubmed.ncbi.nlm.nih.gov/27417968
Publikováno v:
Biochemistry. 49:2732-2740
A class of RNA aptamers that demonstrates a high affinity for a large variety of C(2)H(2) zinc finger proteins was isolated from a library of random RNA sequences by the zinc finger protein TFIIIA. These aptamers have one or more copies of the consen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3156179180e829fa898e589d104512
https://doi.org/10.1021/bi9016654
https://doi.org/10.1021/bi9016654
Publikováno v:
Biochemistry. 49:679-686
The ZFY protein is a member of one of the most interesting classes of polydactyl zinc finger proteins. It has a domain of 13 tandem zinc fingers that is organized with an internal repeat of odd-even finger pairs. It has been proposed that each finger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d2a698ee9b6af5a0f651591a03b5da
https://doi.org/10.1021/bi9018626
https://doi.org/10.1021/bi9018626
Autor:
Paul J. Romaniuk, Tristen C. Weiss
Publikováno v:
Biochemistry. 48:148-155
In addition to binding to DNA, the zinc finger protein WT1 can also bind specifically to RNA. To determine the role of individual zinc fingers of the protein in this RNA binding activity, deletion and substitution mutants of the WT1 zinc finger domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cb27e8450ebcd044f1cc542e6af9b3
https://doi.org/10.1021/bi801586a
https://doi.org/10.1021/bi801586a
Autor:
Paul J. Romaniuk, Cheng YangC. Yang
Publikováno v:
Biochemistry and Cell Biology. 86:312-321
Alternative splicing of the primary transcript of the Wilms’ tumour suppressor gene WT1 involving 2 overlapping 5′ splice sites at the end of exon 9 results in the insertion of 2 amino acids (KTS) between zinc fingers 3 and 4 of the protein. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2eaf038e809b9deb286870031f496c4
https://doi.org/10.1139/o08-075
https://doi.org/10.1139/o08-075
Autor:
Paul J. Romaniuk
Publikováno v:
The Wilms' Tumor (WT1) Gene ISBN: 9781493940219
Equilibrium binding of WT1 to specific sites in DNA and potentially RNA molecules is central in mediating the regulatory roles of this protein. In order to understand the functional effects of mutations in the nucleic acid-binding domain of WT1 prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ccb1d3883da3f047916885f19fb7f39
https://doi.org/10.1007/978-1-4939-4023-3_14
https://doi.org/10.1007/978-1-4939-4023-3_14
Publikováno v:
Biochemistry. 40:2032-2040
The interaction of the zinc finger protein WT1 with RNA aptamers has been investigated using a quantitative binding assay, and the results have been compared to those from a previous study of the DNA binding properties of this protein. A recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d857ed05e7937d4d221d02c138da4691
https://doi.org/10.1021/bi001941r
https://doi.org/10.1021/bi001941r
Publikováno v:
Experimental Cell Research. 247:257-266
The product of the Wilm's tumor suppressor gene, WT1, is a zinc-finger DNA-binding protein, which is thought to be a transcription factor. Two genes, those encoding epidermal growth factor receptor and syndecan-1, are known to be endogenous targets o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb94e098789a94a61881393fdd630ae0
https://doi.org/10.1006/excr.1998.4361
https://doi.org/10.1006/excr.1998.4361
Publikováno v:
Journal of Biological Chemistry. 271:19464-19474
Nuclear hormone receptors bind to hormone response elements in DNA consisting of two half-sites of 6 base pairs. The P-box amino acids of each receptor determine the identities of the central nucleotides of the half-site. 57 P-box variants of the hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d2787227aa0493081c98d919a4bb9a
https://doi.org/10.1074/jbc.271.32.19464
https://doi.org/10.1074/jbc.271.32.19464