Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Paul J, Brighton"'
Autor:
Laura Fernández, Chow-Seng Kong, Majd Alkhoury, Maria Tryfonos, Paul J. Brighton, Thomas M. Rawlings, Joanne Muter, Maria Soledad Gori, Claudia Pérez Leirós, Emma S. Lucas, Jan J. Brosens, Rosanna Ramhorst
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Decidualization denotes the process of inflammatory reprogramming of endometrial stromal cells (EnSC) into specialized decidual cells (DC). During this process, EnSC are subjected to endoplasmic reticulum (ER) stress as well as acute cellula
Externí odkaz:
https://doaj.org/article/10a4a1168d4746c89760779899871377
Autor:
Paul J. Brighton, Abigail R. Walker, Oliver Mann, Chow-Seng Kong, Emma S. Lucas, Pavle Vrljicak, Jan J. Brosens, Aylin C. Hanyaloglu
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111170- (2024)
Summary: Decidualization denotes the differentiation of endometrial stromal cells into specialized decidual cells, essential for embryo implantation and pregnancy. The process requires coordination of progesterone and cAMP signaling, which converge o
Externí odkaz:
https://doaj.org/article/721ff821f6494eebbf78c87130c099a0
Autor:
Shreeya Tewary, Emma S. Lucas, Risa Fujihara, Peter K. Kimani, Angela Polanco, Paul J. Brighton, Joanne Muter, Katherine J. Fishwick, Maria José Minhoto Diniz Da Costa, Lauren J. Ewington, Lauren Lacey, Satoru Takeda, Jan J. Brosens, Siobhan Quenby
Publikováno v:
EBioMedicine, Vol 51, Iss , Pp - (2020)
Background: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury. Here, we
Externí odkaz:
https://doaj.org/article/de5eb3be77e347e7bc8637c113690891
Autor:
Paul J Brighton, Yojiro Maruyama, Katherine Fishwick, Pavle Vrljicak, Shreeya Tewary, Risa Fujihara, Joanne Muter, Emma S Lucas, Taihei Yamada, Laura Woods, Raffaella Lucciola, Yie Hou Lee, Satoru Takeda, Sascha Ott, Myriam Hemberger, Siobhan Quenby, Jan Joris Brosens
Publikováno v:
eLife, Vol 6 (2017)
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs), le
Externí odkaz:
https://doaj.org/article/667854c7f71a4875a2003ebd85d55dec
Autor:
Emma S. Lucas, Thomas M Rawlings, Amelia Hawkes, Joshua Odendaal, Katherine J. Fishwick, Maria Diniz-da-Costa, Siobhan Quenby, Jan J. Brosens, Pavle Vrljicak, Sascha Ott, Chow-Seng Kong, Paul J. Brighton
Pregnancy depends on the wholesale transformation of the endometrium, a process driven by differentiation of endometrial stromal cells (EnSC) into specialist decidual cells. Upon embryo implantation, decidual cells impart the tissue plasticity needed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6107bb31617fbc4a6b108edf695408c1
http://wrap.warwick.ac.uk/153073/1/WRAP-characterization-highly-proliferative-decidual-precursor-cells-window-implantation-human-endometrium-Brighton-2021.pdf
http://wrap.warwick.ac.uk/153073/1/WRAP-characterization-highly-proliferative-decidual-precursor-cells-window-implantation-human-endometrium-Brighton-2021.pdf
Autor:
Tina Tremaine, Chow-Seng Kong, Emma Salisbury, Rita Vassena, Paul J. Brighton, Alexandra Almansa Ordoñez, Emma S. Lucas, Geraldine M. Hartshorne, Joanne Muter, Ali A. Fouladi-Nashta, Sarah Turner, Jan J. Brosens, Gustavo Tiscornia
Publikováno v:
The FASEB Journal
Decidualizing endometrial stromal cells (EnSC) critically determine the maternal response to an implanting conceptus, triggering either menstruation‐like disposal of low‐fitness embryos or creating an environment that promotes further development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c77e1ae3e752b2fe944e2965f9b0fb
http://wrap.warwick.ac.uk/146317/17/WRAP-embryo-biosensing-uterine-natural-killer-cells-determines-endometrial-fate-decisions-implantation-Brighton-2020.pdf
http://wrap.warwick.ac.uk/146317/17/WRAP-embryo-biosensing-uterine-natural-killer-cells-determines-endometrial-fate-decisions-implantation-Brighton-2020.pdf
Autor:
Sarah Turner, Gustavo Tiscornia, Ali A. Fouladi-Nashta, Tina Tremaine, Joanne Muter, Alexandra Almansa Ordoñez, Chow-Seng Kong, Geraldine M. Hartshorne, Jan J. Brosens, Emma S. Lucas, Rita Vassena, Emma Salisbury, Paul J. Brighton
Decidualizing endometrial stromal cells (EnSC) critically determine the maternal response to an implanting conceptus, triggering either menstruation-like disposal of low-fitness embryos or creating an environment that promotes further development. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a39132550b760cb8ad03483c3614722
https://doi.org/10.1101/2020.08.14.251033
https://doi.org/10.1101/2020.08.14.251033
Autor:
Justin C. Konje, Paul J. Brighton, Lucy Sanders, Alexander Pearce, Shashi Rana, Jonathon M. Willets
Publikováno v:
Cellular Signalling. 38:182-191
Activation of Gs coupled receptors (e.g. β2-adrenoreceptor (β2AR)) expressed within the uterine muscle layer (myometrium), promotes intracellular cAMP generation, inducing muscle relaxation through short-term inhibition of contractile proteins, and
Autor:
Anatoly Shmygol, Andrew M. Blanks, Siobhan Quenby, Joanne Muter, Jan J. Brosens, Paul J. Brighton, Emma S. Lucas, Lauren Lacey
Publikováno v:
Endocrinology
Decidualization denotes the transformation of endometrial stromal cells into specialized decidual cells. In pregnancy, decidual cells form a protective matrix around the implanting embryo, enabling coordinated trophoblast invasion and formation of a
Autor:
Maria J. Costa, Satoru Takeda, Peter K. Kimani, Jan J. Brosens, Paul J. Brighton, Siobhan Quenby, Shreeya Tewary, Risa Fujihara, Katherine J. Fishwick, Angela Polanco, Emma S. Lucas, Joanne Muter, Lauren J. Ewington, Lauren Lacey
Publikováno v:
SSRN Electronic Journal.
Background: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury by prevent