Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Paul I. Mapp"'
Autor:
Peter R. W. Gowler, Paul I. Mapp, James J. Burston, Mohsen Shahtaheri, David A. Walsh, Victoria Chapman, Simon Beggs
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining sur
Externí odkaz:
https://doaj.org/article/e17abc8f5d8247c79aa78d0c3f36b30a
Autor:
Alasdair G. Kay, Alicia J. El Haj, Luting Xu, Hareklea Markides, Paul I. Mapp, Robert H. Morris, Oksana Kehoe, Devi Rani Sagar, James J. Burston, Victoria Chapman
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Stem Cells International
Stem Cells International
Background. Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58495ab6d2b9d0efd8a17873a64ab894
https://doi.org/10.1155/2017/2905104
https://doi.org/10.1155/2017/2905104
Autor:
Micah J. Niphakis, Victoria Chapman, David A. Barrett, Sarir Sarmad, James J. Burston, Paul I. Mapp, David A. Walsh, Benjamin F. Cravatt
Publikováno v:
British Journal of Pharmacology. 173:3134-3144
Background and purpose: Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate, or are associated with serious side effects. The endocannabinoid system may offer alternative targets for pain-rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d926d628c4041159dd5d97a554c4d1d9
https://doi.org/10.1111/bph.13574
https://doi.org/10.1111/bph.13574
Autor:
David A. Walsh, Paul I. Mapp, Victoria Chapman, Mohsen Shahtaheri, James J. Burston, Peter R W Gowler
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239663 (2020)
PLoS ONE, Vol 15, Iss 9, p e0239663 (2020)
The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cb7296fff1ede1a69b6e93b5001c2b
https://doi.org/10.1371/journal.pone.0239663
https://doi.org/10.1371/journal.pone.0239663
Publikováno v:
Cartilage, synovium and bone.
Background Knee osteoarthritis (OA) is associated with ongoing pain and joint damage that can be punctuated by acute flares of pain and inflammation. Acute synovitis in normal knees might resolve without long-term detriment to joint function. Objecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1cba43f5f9c742a0b3462cdf59ececf
https://doi.org/10.1136/annrheumdis-2018-eular.4560
https://doi.org/10.1136/annrheumdis-2018-eular.4560
Publikováno v:
Osteoarthritis and cartilage. 26(10)
Summary Objective Knee osteoarthritis (OA) is associated with ongoing pain and joint damage that can be punctuated by acute flares of pain and inflammation. Synovitis in normal knees might resolve without long-term detriment to joint function. We hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab4fa91213b9b90a56aa1d2e9f3bc98
https://pubmed.ncbi.nlm.nih.gov/30031926
https://pubmed.ncbi.nlm.nih.gov/30031926
Autor:
Junting Huang, Paul I. Mapp, Brigitte E. Scammell, Sadaf Ashraf, Andrew J. Bennett, Srinivasarao Ravipati, David A. Barrett, Petros Pousinis, Victoria Chapman, James J. Burston, Li Li
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Objective Pain is a major symptom of osteoarthritis (OA); currently available analgesics either do not provide adequate pain relief or are associated with serious side effects. The aim of this study was to investigate the therapeutic potential of tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28423c0f8ecb7c40764ea7d2bb211302
https://orca.cardiff.ac.uk/id/eprint/112055/1/Huang_et_al-2017-Arthritis_%26_Rheumatology.pdf
https://orca.cardiff.ac.uk/id/eprint/112055/1/Huang_et_al-2017-Arthritis_%26_Rheumatology.pdf
Autor:
Eamonn Ferguson, Brigitte E. Scammell, L.A. Wyatt, Bryan J. Moreton, Paul I. Mapp, David A. Walsh, D. Wilson, R. Hill
Publikováno v:
Osteoarthritis and cartilage. 25(1)
Objective: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd557072d6172ae4aab84d5d533cf60
https://pubmed.ncbi.nlm.nih.gov/27720884
https://pubmed.ncbi.nlm.nih.gov/27720884
Publikováno v:
British Journal of Pharmacology. 166:1261-1271
BACKGROUND AND PURPOSE We have tested the hypothesis that calcitonin gene-related peptide (CGRP) is a mediator of capsaicin-induced angiogenesis in vivo. EXPERIMENTAL APPROACH In a series of experiments, the knee joints of rats were injected with CGR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dcc68f3fe971f3bbb2427b57357451f
https://doi.org/10.1111/j.1476-5381.2012.01848.x
https://doi.org/10.1111/j.1476-5381.2012.01848.x
Autor:
David A. Walsh, Paul I. Mapp, Daniel F. McWilliams, Rebecca E. Fransès, D. Wilson, Matthew J. Turley, Madeleine R. Dixon
Publikováno v:
Rheumatology (Oxford, England)
Objectives. The osteochondral junction can be a source of pain in both RA and OA. Growth of blood vessels and nerves from the subchondral bone into articular cartilage may mediate the association between joint pathology and symptoms. We have investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ad806bf253ff80024a88bbca587598
https://doi.org/10.1093/rheumatology/keq188
https://doi.org/10.1093/rheumatology/keq188