Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Paul Huter"'
Autor:
Michael Graf, Paul Huter, Cristina Maracci, Miroslav Peterek, Marina V. Rodnina, Daniel N. Wilson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
In bacteria, the process of translation termination is performed by three termination release factors RF1, RF2 and RF3. Here the authors provide detailed structural insights into the mechanism by which RF1 is dissociated from the ribosome by RF3 duri
Externí odkaz:
https://doaj.org/article/3b0348d792cc49c684d9dc7463803808
Publikováno v:
Trends in Biochemical Sciences. 42:669-680
Ribosomes that translate mRNAs lacking stop codons become stalled at the 3' end of the mRNA. Recycling of these stalled ribosomes is essential for cell viability. In bacteria three ribosome rescue systems have been identified so far, with the most ub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4aebf4760d0538cbafd701c5ab5cb6c
https://doi.org/10.1016/j.tibs.2017.05.009
https://doi.org/10.1016/j.tibs.2017.05.009
Autor:
Paul Huter, Daniel N. Wilson, Scott C. Blanchard, Stefan Arenz, Fabian Nguyen, Manuel F. Juette, Michael Graf, Yury S. Polikanov
Publikováno v:
Proceedings of the National Academy of Sciences. 113:7527-7532
The ribosome is one of the major targets for therapeutic antibiotics; however, the rise in multidrug resistance is a growing threat to the utility of our current arsenal. The orthosomycin antibiotics evernimicin (EVN) and avilamycin (AVI) target the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06d954fe29237266212734469948395
https://doi.org/10.1073/pnas.1604790113
https://doi.org/10.1073/pnas.1604790113
Autor:
Cristina Maracci, Marina V. Rodnina, Paul Huter, Miroslav Peterek, Michael Graf, Daniel N. Wilson
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
During translation termination in bacteria, the release factors RF1 and RF2 are recycled from the ribosome by RF3. While high-resolution structures of the individual termination factors on the ribosome exist, direct structural insight into how RF3 me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf29ecc2a445f2740316f3db2ba35412
Autor:
Kai Hilpert, Monica Benincasa, Natacha Pérébaskine, Mario Mardirossian, Claudia Müller, Sven Hofmann, Alessandro Tossi, C. Axel Innis, Daniel N. Wilson, Stefano Gambato, Paul Huter
Publikováno v:
Cell Chemical Biology
Proline-rich antimicrobial peptides (PrAMPs) internalize into susceptible bacteria using specific transporters and interfere with protein synthesis and folding. To date, mammalian PrAMPs have so far only been identified in artiodactyls. Since cetacea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c19785f1af488ae214333cf5423680a
http://hdl.handle.net/11368/2921544
http://hdl.handle.net/11368/2921544
Autor:
Helmut Grubmueller, Andrea C. Vaiana, Paul Huter, Stefan Arenz, Michael Graf, Lars V. Bock, Dan Wilson
Publikováno v:
Biophysical Journal
Ribosomal stalling during protein synthesis in bacteria occurs in different ways and under different conditions. Stalling of specific peptide sequences can be a pre-programmed means of detecting the presence of potentially lethal antibiotics and cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffe0daea7a2840708dc7edc00f2272a
https://hdl.handle.net/11858/00-001M-0000-002D-7484-B11858/00-001M-0000-002D-7482-F
https://hdl.handle.net/11858/00-001M-0000-002D-7484-B11858/00-001M-0000-002D-7482-F
Publikováno v:
Nucleic Acids Research
Ribosomes are the protein synthesizing machines of the cell. Recent advances in cryo-EM have led to the determination of structures from a variety of species, including bacterial 70S and eukaryotic 80S ribosomes as well as mitoribosomes from eukaryot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b88097a2d1588bf6f1211cbfea68db
Autor:
Michael Graf, Andrea C. Vaiana, Tanel Tenson, Agata L. Starosta, Roland Beckmann, André Heuer, Lauri Peil, Stefan Arenz, Helmut Grubmüller, Daniel N. Wilson, Jiří Nováček, Paul Huter, Marina V. Rodnina, Otto Berninghausen, Frank Peske, Ingo Wohlgemuth, Jan Ole Frister, Lars V. Bock
Publikováno v:
Molecular Cell
Ribosomes synthesizing proteins containing consecutive proline residues become stalled and require rescue via the action of uniquely modified translation elongation factors, EF-P in bacteria, or archaeal/eukaryotic a/eIF5A. To date, no structures exi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e1ff922c79b418f06bd4a1a649ace0
Publikováno v:
RNA Biology
Ribosomal decoding is an essential process in every living cell. During protein synthesis the 30S ribosomal subunit needs to accomplish binding and accurate decoding of mRNAs. From mutational studies and high-resolution crystal structures nucleotides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4f5c3e9779ed999a080cffae8654d78
https://pubmed.ncbi.nlm.nih.gov/27841727
https://pubmed.ncbi.nlm.nih.gov/27841727