Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Paul Hinton"'
Autor:
Yue Wang, Jie Xue, Umesh Muchhal, Keyu Li, Angus Sinclair, Poonam Yakkundi, Rodnie Rosete, Bruce Keyt, Liqin Liu, Deepal Pandya, Vidhya Bai Krishnoji Rao, Elizabeth Perez, Paul Hinton, Gene Li, Kristene Mai, Nardeen Hanna, Zhongde Ye, Jinqiu Wang, Tina Mao, Palak Chudasama, Sachi Rahman, Zee Malik, Krzysztof Bzymek
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/48b4c1c1bc81453ba906e5b5b2b62cf8
Autor:
Umesh Muchhal, Angus Sinclair, Dean Ng, Bruce Keyt, Sarang Tartey, Vignesh Narayanaswamy, Deepal Pandya, Vidhya Bai Krishnoji Rao, Elizabeth Perez, Paul Hinton, Hyewon Phee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/e16717cae9f944beb89fd9aa4f3af8ac
Autor:
Adam Smith, Umesh Muchhal, Dean Ng, Poonam Yakkundi, Gary Bolton, Yuan Cao, Tasnim Kothambawala, Beatrice Wang, Deepal Pandya, Vidhya Bai Krishnoji Rao, Elizabeth Perez, Paul Hinton, Hyewon Phee, Sachi Rahman, Thin Wai, Natalia L dos Santos, Aditya Bharti, Balaji Banoth, Harrison Horwitz, Bruce A Keyt, Angus M Sinclair
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4c8e7d12c85d4daa81db1486279b066b
Autor:
Gene Li, Ling Wang, Poonam Yakkundi, Paul Hinton, Deepal Pandya, Keerthana Sekar, Rodine Rosete, Zhongde Ye, Nardeen Hanna, Maya F. Kotturi, Liz Bogaert, Jiyoung Hong, Christina Tsai, Thomas Manley, Bruce A. Keyt, Angus M. Sinclair, Liqin Liu
Publikováno v:
Cancer Research. 83:2933-2933
Novel therapeutics are needed for the effective treatment of acute myeloid leukemia (AML), as standard chemotherapeutics are poorly tolerated and ~50% of patients relapse primarily due to the incomplete elimination of leukemia stem cells (LSCs). CD12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6bab38bf508e62130e1680f5acf6766
https://doi.org/10.1158/1538-7445.am2023-2933
https://doi.org/10.1158/1538-7445.am2023-2933
Autor:
Maya Leabman, Bruce Keyt, Kevin C. Hart, Xingjie Chen, Rodnie Rosete, Angus M. Sinclair, Yuan Cao, Poonam Yakkundi, Eric W. Humke, Paul Hinton, Ling Wang, Mélanie Desbois, Maya F. Kotturi, Beatrice Tien-Yi Wang, Tasnim Kothambawala, Genevive Hernandez, Susan E. Calhoun, Katie Cha, Thomas J. Matthew
Publikováno v:
Cancer Research. 81:52-52
Death receptor 5 (DR5) is a member of the tumor necrosis factor (TNF) receptor superfamily that activates the extrinsic apoptotic pathway when bound and multimerized by its ligand, TNF-related apoptosis inducing ligand (TRAIL). DR5 is broadly express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d28ce101c386119952c7f84ce0efc46f
https://doi.org/10.1158/1538-7445.am2021-52
https://doi.org/10.1158/1538-7445.am2021-52
Autor:
Paul Hinton, Bruce Keyt, Daniel S. Chen, Madeline H. Tran, Chitra Saraiya, Ramesh Baliga, Stephen F. Carroll, Dean C. Ng, Marigold Manlusoc, Hai Lu, Yuan C. Cao, Sachi Rahman, Bing Shan, Marvin Peterson, Keyu Li, Avneesh Saini
Publikováno v:
Cancer Research. 80:5664-5664
We have developed a novel T cell engaging bispecific antibody platform that utilizes the high avidity of IgM antibodies, but further combines this with the high affinity and specificity of IgG antibodies. By grafting the affinity matured binding doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dec4ac4d1533b85b287cbaafcb38305
https://doi.org/10.1158/1538-7445.am2020-5664
https://doi.org/10.1158/1538-7445.am2020-5664
Autor:
Bruce Keyt, Chitra Saraiya, Dean Ng, Ramesh Baliga, Steve Carroll, Avneesh Saini, Paul Hinton, Sachi Rahman, Keyu Li, Madeline Tran, Bing Shan, Marigold Manlusoc, Hai Lu, Marvin Peterson, Yuan Cao, Wayne R. Godfrey
Publikováno v:
Journal of Clinical Oncology. 38:e15007-e15007
e15007 Background: Bispecific antibodies which tether T-cells to cancer cells, and additionally activate T-cell mediated killing, have shown promise in treating B-cell malignancies. Dose intensity, however, is limited by cytokine release from the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16915fffcd12570d1b4a753f489c2e6
https://doi.org/10.1200/jco.2020.38.15_suppl.e15007
https://doi.org/10.1200/jco.2020.38.15_suppl.e15007
Autor:
Steve Carroll, Marvin Peterson, Marigold Manlusoc, Bing Shan, Hai Lu, Sachi Rahman, Ramesh Baliga, Paul Hinton, Yuan Cao, Chitra Saraiya, Bruce Keyt, Daniel S. Chen, Dean Ng, Keyu Li, Madeline Tran, Avneesh Saini
Publikováno v:
Blood. 134:1574-1574
Unlike IgG antibodies, IgM antibodies are typically composed of a pentameric disc-like structure with 10 low affinity binding sites per molecule complexed with a joining chain (J-chain) protein. We have developed a novel T cell engaging bispecific an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0e6d26fddb5fbfb741e751a4cd37fc
https://doi.org/10.1182/blood-2019-131650
https://doi.org/10.1182/blood-2019-131650
Publikováno v:
Computer Law & Security Review. 28:340-346
While latency issues have always existed in IT systems, it is only in recent years that latency has become a significant focal point for both IT suppliers and customers. This paper will provide an overview as to how latency arises in IT systems, why
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ace49f0cf684da3713f60273aaff66e
https://doi.org/10.1016/j.clsr.2012.03.011
https://doi.org/10.1016/j.clsr.2012.03.011
Publikováno v:
Computer Law & Security Review. 27:139-151
It is now apposite to speak of the ‘data centric world’. Businesses are paying ever more attention to their own, and others’ data, as a way of adding value to the organisation and conferring competitive advantage. This in turn is focusing atten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f17326056b97865b7abe459ce0e943
https://doi.org/10.1016/j.clsr.2011.01.003
https://doi.org/10.1016/j.clsr.2011.01.003