Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Paul Heuschling"'
Autor:
Cindy Birck, Aurélien Ginolhac, Maria Angeliki S. Pavlou, Alessandro Michelucci, Paul Heuschling, Luc Grandbarbe
Publikováno v:
Cells, Vol 10, Iss 4, p 840 (2021)
The NF-κB signaling pathway is crucial during development and inflammatory processes. We have previously shown that NF-κB activation induces dedifferentiation of astrocytes into neural progenitor cells (NPCs). Here, we provide evidence that the NF-
Externí odkaz:
https://doaj.org/article/3927d0a841cb4142af41f5bc820af07b
Autor:
Cindy Birck, Eric Koncina, Tony Heurtaux, Enrico Glaab, Alessandro Michelucci, Paul Heuschling, Luc Grandbarbe
Publikováno v:
Genomics Data, Vol 7, Iss , Pp 7-11 (2016)
Astrocytes, the most abundant glial cell population in the central nervous system, have important functional roles in the brain as blood brain barrier maintenance, synaptic transmission or intercellular communications [1,2]. Numerous studies suggeste
Externí odkaz:
https://doaj.org/article/4b263038b56a467091ff38cd6ec21d12
Autor:
Claire Hoenen, Audrey Gustin, Cindy Birck, Mélanie Kirchmeyer, Nicolas Beaume, Paul Felten, Luc Grandbarbe, Paul Heuschling, Tony Heurtaux
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162717 (2016)
Parkinson's disease (PD) is histologically described by the deposition of α-synuclein, whose accumulation in Lewy bodies causes dopaminergic neuronal death. Although most of PD cases are sporadic, point mutations of the gene encoding the α-synuclei
Externí odkaz:
https://doaj.org/article/6cca9f41bfa64ac382a001fe5636d78d
Autor:
Audrey Gustin, Mélanie Kirchmeyer, Eric Koncina, Paul Felten, Sophie Losciuto, Tony Heurtaux, Aubry Tardivel, Paul Heuschling, Catherine Dostert
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130624 (2015)
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia, are able to trigger an appropriate response involving secretion of cytokines and chemokines,
Externí odkaz:
https://doaj.org/article/a651de33a360456c83b6f5c5120ba84f
Autor:
Aurélien Ginolhac, Cindy Birck, Paul Heuschling, Alessandro Michelucci, Maria Angeliki S. Pavlou, Luc Grandbarbe
Publikováno v:
Cells
Volume 10
Issue 4
Cells, Vol 10, Iss 840, p 840 (2021)
Volume 10
Issue 4
Cells, Vol 10, Iss 840, p 840 (2021)
The NF-κB signaling pathway is crucial during development and inflammatory processes. We have previously shown that NF-κB activation induces dedifferentiation of astrocytes into neural progenitor cells (NPCs). Here, we provide evidence 
th
th
Autor:
Alessandro Michelucci, Enrico Glaab, Cindy Birck, Luc Grandbarbe, G. Dorban, Eric Koncina, Tony Heurtaux, Sebastien Gabel, Paul Heuschling
Publikováno v:
Molecular Neurobiology, 53(8), 5041-5055. (2015).
Molecular Neurobiology
Molecular Neurobiology
Brain inflammation, a common feature in neurodegenerative diseases, is a complex series of events, which can be detrimental and even lead to neuronal death. Nonetheless, several studies suggest that inflammatory signals are also positively influencin
Autor:
Luc Grandbarbe, Mélanie Kirchmeyer, Paul Heuschling, Paul Felten, Tony Heurtaux, Cindy Birck, Nicolas Beaume, Claire Hoenen, Audrey Gustin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0162717 (2016)
PLoS ONE. San Franscisco, CA: Public Library of Science (2016).
PLoS ONE, Vol 11, Iss 9, p e0162717 (2016)
PLoS ONE. San Franscisco, CA: Public Library of Science (2016).
Parkinson’s disease (PD) is histologically described by the deposition of α-synuclein, whose accumulation in Lewy bodies causes dopaminergic neuronal death. Although most of PD cases are sporadic, point mutations of the gene encoding the α-synucl
Autor:
Tony Heurtaux, Paul Heuschling, Paul Felten, Eleonora Morga, Christian Gallotti, Sophie Losciuto, Luc Grandbarbe, Alessandro Michelucci, G. Dorban
Publikováno v:
Journal of Neurochemistry. 114:576-586
Alzheimer's disease (AD) is characterized by the presence of extracellular deposits referred to beta-amyloid (Abeta) complexes or senile plaques. Abeta peptide is firstly produced as monomers, readily aggregating to form multimeric complexes, of whic
Publikováno v:
Journal of Neuroimmunology. 210:3-12
M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS
Publikováno v:
Tetrahedron. 62:12025-12040
The synthesis of tocopherol fatty alcohols (TFAs), potent microglial activation modulators, was achieved via C -alkylation of trimethylhydroquinone. Several analogs, in particular water-soluble prodrugs, have been synthesized using a Wittig reaction