3D quantitative imaging of unprocessed live tissue reveals epithelial defense against bacterial adhesion and subsequent traversal requires MyD88.

Autor: Connie Tam, Jeffrey LeDue, James J Mun, Paul Herzmark, Ellen A Robey, David J Evans, Suzanne M J Fleiszig

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e24008 (2011)

While a plethora of in vivo models exist for studying infectious disease and its resolution, few enable factors involved in the maintenance of health to be studied in situ. This is due in part to a paucity of tools for studying subtleties of bacteria

Externí odkaz: https://doaj.org/article/4a770f2649694bfca29d7ff106001349

Dynamics of T Cell, Antigen-Presenting Cell, and Pathogen Interactions during Recall Responses in the Lymph Node

Autor: Tatyana Chtanova, Boris Striepen, Paul Herzmark, Seong-Ji Han, Giel G. van Dooren, Ellen A. Robey, Marie Schaeffer

Publikováno v: Immunity. 31(2):342-355

SummaryMemory T cells circulate through lymph nodes where they are poised to respond rapidly upon re-exposure to a pathogen; however, the dynamics of memory T cell, antigen-presenting cell, and pathogen interactions during recall responses are largel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46da6f9e9d5d22ecc875179f12b4684

Bound attractant at the leading vs. the trailing edge determines chemotactic prowess

Autor: Hana El-Samad, Kit Wong, Fei Wang, Alex Groisman, Paul Herzmark, Kyle Campbell, Henry R. Bourne

Publikováno v: Proceedings of the National Academy of Sciences. 104:13349-13354

We have analyzed chemotaxis of neutrophil-differentiated HL60 cells in microfluidic devices that create exponential gradients of the chemoattractant, f-Met-Leu-Phe (fMLP). Such gradients expose each cell to a difference in fMLP concentration (ΔC) ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef1a3feb32b2bc4e88c49f9fa0ef114
https://doi.org/10.1073/pnas.0705889104

Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns

Autor: Ellen A. Robey, Arthur Weiss, Heather J. Melichar, Jenny O. Ross, Paul Herzmark, Byron B. Au-Yeung

Publikováno v: Ross, JO; Melichar, HJ; Au-Yeung, BB; Herzmark, P; Weiss, A; & Robey, EA. (2014). Distinct phases in the positive selection of CD8+T cells distinguished by intrathymic migration and T-cell receptor signaling patterns. Proceedings of the National Academy of Sciences of the United States of America, 111(25). doi: 10.1073/pnas.1408482111. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8062w4x0
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 25

Positive selection of CD8 T cells in the thymus is thought to be a multistep process lasting 3-4 d; however, the discrete steps involved are poorly understood. Here, we examine phenotypic changes, calcium signaling, and intrathymic migration in a syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbf6a2afb39491abaefb4a9df6052c2
https://europepmc.org/articles/PMC4078834/

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

Autor: Henry R. Bourne, Guy Servant, Orion D. Weiner, John W. Sedat, Paul Herzmark, Tamas Balla

Publikováno v: Science. 287:1037-1040

Morphologic polarity is necessary for chemotaxis of mammalian cells. As a probe of intracellular signals responsible for this asymmetry, the pleckstrin homology domain of the AKT protein kinase (or protein kinase B), tagged with the green fluorescent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b39026fe53acc74ad87d0c7470f54c
https://doi.org/10.1126/science.287.5455.1037