Výsledky vyhledávání - "Paul Hekerman"

BCL-6: a possible missing link for anti-inflammatory PPAR-δ signalling in pancreatic beta cells

Autor: Ronald M. Evans, Paul Hekerman, Martine I. Darville, Miriam Cnop, C.-H. Lee, Decio L. Eizirik, Ilham Kharroubi

Publikováno v: Diabetologia. 49:2350-2358

Inflammatory mediators contribute to pancreatic beta cell death in type 1 diabetes. Beta cells respond to cytokine exposure by activating gene networks that alter cellular metabolism, induce chemokine release (thereby increasing insulitis), and cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4369724e5e31eca1420913c7125d53
https://doi.org/10.1007/s00125-006-0366-5

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Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

Autor: Jan Tavernier, Paul Hekerman, Hans-Georg Joost, Julia Zeidler, Simone Bamberg-Lemper, Delphine Lavens, Holger Knobelspies, Walter Becker

Publikováno v: FEBS Journal. 272:109-119

The leptin receptor (LEPR) is a class I cytokine receptor signalling via both the janus kinase/signal transducer and activator of transcription (JAK/STAT) and the MAP kinase pathways. In addition, leptin has been shown previously to activate AMP-acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edb9368fb35d023b7938a105bb410e8b
https://doi.org/10.1111/j.1432-1033.2004.04391.x

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Characterization of Cyclin L2, a Novel Cyclin with an Arginine/Serine-rich Domain

Autor: Walter Becker, Gerhard Müller-Newen, Katrin de Graaf, Andreas Herrmann, Oliver Spelten, Konrad Büssow, Paul Hekerman, Len C. Packman

Publikováno v: Journal of Biological Chemistry. 279:4612-4624

A novel method employing filter arrays of a cDNA expression library for the identification of substrates for protein kinases was developed. With this technique, we identified a new member of the cyclin family, cyclin L2, as a substrate of the nuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eef8a53c5935dfa4ae385fb8b254f0ba
https://doi.org/10.1074/jbc.m310794200

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Mechanism of attenuation of leptin signaling under chronic ligand stimulation

Autor: Holger Knobelspies, Paul Hekerman, Julia Zeidler, Walter Becker, Simone Bamberg-Lemper

Publikováno v: BMC Biochemistry, Vol 11, Iss 1, p 2 (2010)
BMC Biochemistry
BMC biochemistry 11, 2 (2010). doi:10.1186/1471-2091-11-2

BMC biochemistry 11, 2 (2010). doi:10.1186/1471-2091-11-2
Published by BioMed Central, London

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577abb41a69e62740699e2309940ffbc
https://doi.org/10.1186/1471-2091-11-2

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The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4

Autor: Jan Hendrik Sitz, Walter Becker, Chrisovalantis Papadopoulos, Beat Lutz, Francisco J. Tejedor, Karsten Baumgärtel, Paul Hekerman, Barbara Hämmerle

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The dual-specific kinase DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A) is the mammalian orthologue of the Drosophila minibrain (MNB) protein kinase and executes diverse roles in neuronal development and adult brain physiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6ed23f9231d779787010b6c0e9ac7e
https://pubmed.ncbi.nlm.nih.gov/18938227

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Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

Autor: Zeynep Dogusan, Alessandra K Cardozo, Daisy Flamez, Paul Hekerman, Fernanda Ortis, Miriam Cnop, Laurence Ladrière, Michael Boyce, Junying Yuan, Decio L. Eizirik

Publikováno v: The Journal of biological chemistry. 282(6)

Free fatty acids cause pancreatic beta-cell apoptosis and may contribute to beta-cell loss in type 2 diabetes via the induction of endoplasmic reticulum stress. Reductions in eukaryotic translation initiation factor (eIF) 2alpha phosphorylation trigg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7f74ff07bc067ce2b948a991bc222a
https://pubmed.ncbi.nlm.nih.gov/17158450

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Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

Autor: Paul, Hekerman, Julia, Zeidler, Simone, Bamberg-Lemper, Holger, Knobelspies, Delphine, Lavens, Jan, Tavernier, Hans-Georg, Joost, Walter, Becker

Publikováno v: The FEBS journal. 272(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c1bbb4bbeeb1ec4d055ee38846b55a9
https://pubmed.ncbi.nlm.nih.gov/15634336

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Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors

Autor: Katrin, de Graaf, Paul, Hekerman, Oliver, Spelten, Andreas, Herrmann, Len C, Packman, Konrad, Büssow, Gerhard, Müller-Newen, Walter, Becker

Publikováno v: The Journal of biological chemistry. 279(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2519581c59304c88186920265db2ae45
https://pubmed.ncbi.nlm.nih.gov/14623875

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Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers

Autor: Hans-Georg Joost, Andreas Barthel, Iris Behrmann, Peter C. Heinrich, Walter Becker, Gregor Bahrenberg, Paul Hekerman

Publikováno v: Molecular endocrinology (Baltimore, Md.). 16(4)

Two predominant splice variants of the leptin receptor (LEPR) are coexpressed in leptin-responsive tissues: the long form, LEPRb, characterized as the signal-transducing receptor, and the signaling-defective short form, LEPRa. It is unknown whether h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900af1135f8a02e558aa1afb84ac9853
https://pubmed.ncbi.nlm.nih.gov/11923481

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