Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Paul Hebeisen"'
Autor:
David Adams, Sven Taylor, Stephan Röver, Hans Richter, Jean-Marc Plancher, Jacques Mizrahi, Craig S. Malcolm, Antony R. Knight, Guy A. Kennett, Paul Hebeisen, Ian A. Cliffe, Anne Bourson, Caterina Bissantz, Jon M. Bentley, Mike J. Bickerdike, Agnès Bénardeau, Steven P. Vickers
Publikováno v:
CHIMIA, Vol 58, Iss 9 (2004)
Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease and cancer. There is increasing evidence suggesting an important role for the 5-HT2C receptor in appetite contr
Externí odkaz:
https://doaj.org/article/704809a7a0ca49da9c0163e20d7760c5
Autor:
Erwin Goetschi, Fabienne Ricklin, Peter Reindl, Raffaello Masciadri, Thomas Luebbers, Helmut Link, Dirk Kostrewa, Paul Hebeisen, Hans Gmuender, Peter Angehrn, Frank-Peter Theil
Publikováno v:
CHIMIA, Vol 57, Iss 4 (2003)
Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally derived from this virtually neat enzyme inhibitor.
Externí odkaz:
https://doaj.org/article/ebfc36461a92485ba5c717ea4a86a719
Autor:
Chiara Borsari, Matthias P. Wymann, Pierre Boulay, Claudio Meyer, Uros Stojiljkovic, Paul Hebeisen, Denise Rageot
Publikováno v:
Synthesis. 55:499-509
Morpholine is a heterocyclic moiety that is widely used in medicinal chemistry as a building block. It has unique physicochemical properties, as it can improve both pharmacokinetic and pharmacodynamic properties of active pharmaceutical ingredients.
Autor:
Martina De Pascale, Lukas Bissegger, Chiara Tarantelli, Florent Beaufils, Alessandro Prescimone, Hayget Mohamed Seid Hedad, Omar Kayali, Clara Orbegozo, Luka Raguž, Thorsten Schaefer, Paul Hebeisen, Francesco Bertoni, Matthias P. Wymann, Chiara Borsari
Publikováno v:
European Journal of Medicinal Chemistry. 248:115038
Autor:
Wolfgang Löscher, Denise Rageot, Rohitha Sriramaratnam, Erhan Keles, Petra Hillmann, Matthias Hamburger, Andrea Treyer, Doriano Fabbro, Florent Beaufils, Paul Hebeisen, Anna Melone, Matthias P. Wymann, Martina De Pascale, Lukas Bissegger, Chiara Borsari, Thomas Bohnacker
Publikováno v:
Journal of Medicinal Chemistry. 63:13595-13617
The mechanistic target of rapamycin (mTOR) pathway is hyperactivated in cancer and neurological disorders. Rapalogs and mTOR kinase inhibitors (TORKi) have recently been applied to alleviate epileptic seizures in tuberous sclerosis complex (TSC). Her
Autor:
Markus Neuburger, Matthias P. Wymann, Florent Beaufils, Paul Hebeisen, Alix Dall’Asen, Chiara Borsari, Denise Rageot
Publikováno v:
Organic Process Research & Development. 23:2416-2424
A new, scalable, rapid, high yielding, and practical synthesis of 4-(difluoromethyl)pyridin-2-amine provides a key intermediate for the preparation of numerous protein kinase inhibitors and clinica...
Autor:
Chiara Borsari, Doriano Fabbro, Petra Hillmann, Florent Beaufils, Thomas Bohnacker, Matthias P. Wymann, Denise Rageot, Ivan Buslov, Erhan Keles, Alexander M. Sele, Anna Melone, Paul Hebeisen
Publikováno v:
ACS Medicinal Chemistry Letters
The phosphoinositide 3-kinase (PI3K)/mechanistic target of rapamycin (mTOR) pathway is a critical regulator of cell growth and is frequently hyperactivated in cancer. Therefore, PI3K inhibitors represent a valuable asset in cancer therapy. Herein we
Autor:
Petra Hillmann, Thomas Bohnacker, Matthias P. Wymann, Alix Dall’Asen, Eileen Jackson, Anna Melone, Florent Beaufils, Denise Rageot, Jean-Baptiste Langlois, Alexander M. Sele, Doriano Fabbro, Paul Hebeisen, Chiara Borsari
Publikováno v:
Journal of Medicinal Chemistry. 62:8609-8630
The mechanistic target of rapamycin (mTOR) plays a pivotal role in growth and tumor progression and is an attractive target for cancer treatment. ATP-competitive mTOR kinase inhibitors (TORKi) have the potential to overcome limitations of rapamycin d
Autor:
Denise Rageot, Thomas Bohnacker, Erhan Keles, Jacob A. McPhail, Reece M. Hoffmann, Anna Melone, Chiara Borsari, Rohitha Sriramaratnam, Alexander M. Sele, Florent Beaufils, Paul Hebeisen, Doriano Fabbro, Petra Hillmann, John E. Burke, Matthias P. Wymann
Publikováno v:
Journal of Medicinal Chemistry. 62:6241-6261
Autor:
Martina De Pascale, Matthias P. Wymann, Matthias Hamburger, Erhan Keles, Andrea Treyer, Chiara Borsari, Paul Hebeisen
Publikováno v:
RSC Medicinal Chemistry
Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound 11 showed predicted BBB permeability in a MDCK-MDR1 permeability in vitro assay, be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b246d81d62b5f3e46c0cb1920a1485
https://edoc.unibas.ch/83494/
https://edoc.unibas.ch/83494/