Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer

Autor: Parkes, Eileen E., Savage, Kienan I., Lioe, Tong, Boyd, Clinton, Halliday, Sophia, Walker, Steven M., Lowry, Keith, Knight, Laura, Buckley, Niamh E., Grogan, Andrena, Logan, Gemma E., Clayton, Alison, Hurwitz, Jane, Kirk, Stephen J., Xu, Jiamei, Sidi, Fatima Abdullahi, Humphries, Matthew P., Bingham, Victoria, Ang, Melvyn, Askin, Conal, Bamford, Louise, Boyd, Ruth, Buckley, Miriam, Clarke, Jacqueline, Darragh, Lynn, Davis, Elaine, Foreman, Jennifer, Gallagher, Rebecca, Gill, Janine, Hanna, Michael, Hill, Naomi, Irwin, Gareth, Mallon, Peter, McAleer, Seamus, McAllister, Joanne, Morris, Melanie, Pierce, Nicole, Refsum, Sigi, Sloan, Samantha, Treanor, Sinead, James, Jacqueline, James, Colin R., Paul Harkin, D., Kennedy, Richard D., McIntosh, Stuart A.

Publikováno v: Parkes, E E, Savage, K I, Lioe, T, Boyd, C, Halliday, S, Walker, S M, Lowry, K, Knight, L, Buckley, N E, Grogan, A, Logan, G E, Clayton, A, Hurwitz, J, Kirk, S J, Xu, J, Sidi, F A, Humphries, M P, Bingham, V, Ang, M, Askin, C, Bamford, L, Boyd, R, Buckley, M, Clarke, J, Darragh, L, Davis, E, Foreman, J, Gallagher, R, Gill, J, Hanna, M, Hill, N, Irwin, G, Mallon, P, McAleer, S, McAllister, J, Morris, M, Pierce, N, Refsum, S, Sloan, S, Treanor, S, James, J, James, C R, Paul Harkin, D, Kennedy, R D & McIntosh, S A 2022, ' Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer ', British Journal of Cancer, vol. 126, no. 2, pp. 247-258 . https://doi.org/10.1038/s41416-021-01599-0
British Journal of Cancer

Background The DNA-damage immune-response (DDIR) signature is an immune-driven gene expression signature retrospectively validated as predicting response to anthracycline-based therapy. This feasibility study prospectively evaluates the use of this a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89093693d780af5cb3b489f2e8467878
https://pure.qub.ac.uk/en/publications/ddcf60ae-b538-40b3-8534-1226cc8804ab

Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer.

Autor: Parkes EE; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK.; Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK.; Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, UK., Savage KI; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK., Lioe T; Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK., Boyd C; Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK., Halliday S; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK., Walker SM; Almac Diagnostic Services, Almac Group, 19 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK., Lowry K; Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK., Knight L; Almac Diagnostic Services, Almac Group, 19 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK., Buckley NE; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK., Grogan A; Almac Diagnostic Services, Almac Group, 19 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK., Logan GE; Almac Diagnostic Services, Almac Group, 19 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK., Clayton A; Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK., Hurwitz J; Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK., Kirk SJ; South Eastern Health and Social Care Trust, Ulster Hospital, Upper Newtownards Road, BT 16 1RH, Dundonald, UK., Xu J; Precision Medicine Centre, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK., Sidi FA; Precision Medicine Centre, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK., Humphries MP; Precision Medicine Centre, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK., Bingham V; Precision Medicine Centre, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK., James JA; Precision Medicine Centre, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK., James CR; Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK., Paul Harkin D; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK.; Almac Diagnostic Services, Almac Group, 19 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK., Kennedy RD; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK.; Almac Diagnostic Services, Almac Group, 19 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK., McIntosh SA; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK. s.mcintosh@qub.ac.uk.; Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK. s.mcintosh@qub.ac.uk.

Publikováno v: British journal of cancer [Br J Cancer] 2022 Feb; Vol. 126 (2), pp. 247-258. Date of Electronic Publication: 2021 Nov 02.

Identification and validation of an anthracycline/cyclophosphamide-based chemotherapy response assay in breast cancer.

Autor: Mulligan JM; Affiliations of authors: Almac Diagnostics, Craigavon, UK (JMM, LAH, SD, KEK, OYR, FAM, EO, MB, SMW, PK, TSD, VP, PGJ, DPH, RDK); Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast, UK (GI, DB, JEQ, PBM, CRJ, JJ, TSD, MS-T, PGJ, DPH, RDK); Department of Health Science Research, Mayo Clinic, Scottsdale, AZ (NML); Department of Medical Genetics, Mayo Clinic, Rochester, MN (FJC)., Hill LA, Deharo S, Irwin G, Boyle D, Keating KE, Raji OY, McDyer FA, O'Brien E, Bylesjo M, Quinn JE, Lindor NM, Mullan PB, James CR, Walker SM, Kerr P, James J, Davison TS, Proutski V, Salto-Tellez M, Johnston PG, Couch FJ, Paul Harkin D, Kennedy RD

Publikováno v: Journal of the National Cancer Institute [J Natl Cancer Inst] 2014 Jan; Vol. 106 (1), pp. djt335.