Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Paul Haines"'
Autor:
Vinay K Kartha, Lukasz Stawski, Rong Han, Paul Haines, George Gallagher, Vikki Noonan, Maria Kukuruzinska, Stefano Monti, Maria Trojanowska
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154645 (2016)
Carcinoma associated fibroblasts (CAFs) form the main constituents of tumor stroma and play an important role in tumor growth and invasion. The presence of CAFs is a strong predictor of poor prognosis of head and neck squamous cell carcinoma. Despite
Externí odkaz:
https://doaj.org/article/6e2a7b0e549c46f0b0bcf96cd7460e3a
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109763 (2014)
MMP-12, a macrophage-secreted elastase, is elevated in fibrotic diseases, including systemic sclerosis (SSc) and correlates with vasculopathy and fibrosis. The goal of this study was to investigate the role of MMP-12 in cardiac and cutaneous fibrosis
Externí odkaz:
https://doaj.org/article/d87bdb6ad8054b0887da4170cb35fb10
Autor:
Maria Trojanowska, Gintas P. Krisciunas, Susan E. Langmore, Michael P. Platt, Gregory A. Grillone, Paul Haines
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 125:228-234
Objectives: Radiation-induced fibrosis is a common complication for patients following head and neck cancer treatment. This study presents a novel minimally invasive protocol for molecular study of fibrosis in the stromal tissues. Methods: Subjects w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b4cbd2ed26df3671b306ba5d402f5c
https://doi.org/10.1177/0003489415607527
https://doi.org/10.1177/0003489415607527
Autor:
Agnieszka P. Looney, Maria Trojanowska, T. Toyama, Xaralabos Varelas, Robert W. Simms, Lukasz Stawski, Paul Haines, Aleksander D. Szymaniak, Brendon M. Baker
Publikováno v:
The Journal of investigative dermatology. 138(1)
Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment options. Fumaric acid esters, including dimethyl fumarate (DMF, Tecfidera; Biogen, Cambridge, MA), have shown therapeutic effects in several disease models, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede132465c6df478bdf907916b6d1609
https://pubmed.ncbi.nlm.nih.gov/28870693
https://pubmed.ncbi.nlm.nih.gov/28870693
Publikováno v:
Journal of Cellular and Molecular Medicine
Previous studies have shown that the transforming growth factor (TGF)β/Alk1/Smad1 signaling pathway is constitutively activated in a subset of systemic sclerosis (SSc) fibroblasts and this pathway is a critical regulator of CCN2 gene expression. Cav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ad899a0d956c375ee887c83f4e0660
https://doi.org/10.1111/j.1582-4934.2012.01537.x
https://doi.org/10.1111/j.1582-4934.2012.01537.x
Autor:
Paul Haines, Xiaochun Wei, Yingjie Guan, Richard M. Terek, Lei Wei, Qian Chen, Tingcun Zhao, Xu Yang, Ming Pei
Publikováno v:
American Journal of Physiology-Cell Physiology. 303:C33-C40
Regulatory mechanisms of chondrocyte differentiation in the growth plate are incompletely understood. Here, we find that histone deacetylase 4 (HDAC4) is located in the nucleus of chondrocytes in the proliferation zone and relocates to the cytoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e652ff1852c0e85e654f1f31f1437523
https://doi.org/10.1152/ajpcell.00348.2011
https://doi.org/10.1152/ajpcell.00348.2011
Publikováno v:
Journal of Dermatological Science. 64:210-216
Background Caveolar raft domains, also termed caveolae, are flask shaped invaginations that require the expression of the structural protein caveolin-1 (cav-1). Matrix metalloproteinase 1 (MMP-1) is a collagenase capable of degrading insoluble triple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a299aa98ef3e7b1305a0b32f669dcc6
https://doi.org/10.1016/j.jdermsci.2011.08.005
https://doi.org/10.1016/j.jdermsci.2011.08.005
Publikováno v:
Arthritis & Rheumatism. 63:1729-1737
Scleroderma (SSc) is an autoimmune connective tissue disorder characterized by vascular abnormalities and tissue fibrosis. In SSc, fibroblasts become activated and deposit large amounts of collagen and other extracellular matrix proteins. Although th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76e66d25f4ea612635dee0570de2d467
https://doi.org/10.1002/art.30284
https://doi.org/10.1002/art.30284
Publikováno v:
All Days.
This paper describes the architecture of the Lucius Subsea Production System and the drivers behind it. Novel technologies are detailed including suction pile mounted Pipeline End Manifolds (PLEMs) and chemical injection backpressure regulator valves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de29cd7f7767cae30e9b5e736065e1dc
https://doi.org/10.4043/26016-ms
https://doi.org/10.4043/26016-ms