Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Paul Haberfield"'
Autor:
Orrette R. Wauchope, Frank W. Grasso, Paul Haberfield, Nicola S. Farina, Mo Qi, Aaron T. Frank, Nahed Sawwan, Edyta M. Brzostowska, Alexander Greer, Wang Chan
Publikováno v:
Molecular Diversity. 11:115-118
This paper examines ring size patterns of natural product macrocycles. Evidence is presented that natural macrocycles containing 14-, 16-, and 18-membered rings are of frequent occurrence based on a data mining study. The results raise a question abo
Publikováno v:
Structural Chemistry. 17:347-350
We propose a mechanism that bilateral symmetry yields an entropic advantage for enzyme recognition. We suggest that bilateral symmetry may be a guiding principle used by nature to produce some particularly effective receptor–ligand interactions. An
Autor:
Magdalena Kiprowska, Alexander Greer, Paul Haberfield, Tatyana Voloshchuk, Nicola S. Farina, Orrette R. Wauchope
Publikováno v:
Journal of Natural Products. 67:1141-1146
A literature survey and theoretical calculations have been applied to explore bilateral symmetry in natural product systems. Molecular bilateral symmetry is defined to include C(2) (sigma plane or axis), C(s)(), and C(2)(v)() point groups in molecule
Publikováno v:
Antiviral Chemistry and Chemotherapy. 3:55-63
Recent observations that haernin inhibited the replication of the human immunodeficiency virus (HIV-1) and the reaction between the HIV-1 envelope glycoprotein gp120 and antibodies specific for the V3 hypervariable loop of this glycoprotein were an e
Autor:
I. K. Hewlett, Shibo Jiang, Alexander Robert Neurath, B. Joshi, Nathan Strick, Paul Haberfield
Publikováno v:
Antiviral Chemistry and Chemotherapy. 2:303-312
The anionic triphenylmethane derivative aurintricarboxylic acid (ATA) was reported to inhibit the replication and cytopathogenicity of human immunodeficiency virus type 1 (HIV-1). This antiviral effect, ascribed to the inhibitory activity of ATA on t
Autor:
Paul Haberfield, Thomas P. Rizzo
Publikováno v:
Journal of Inclusion Phenomena and Molecular Recognition in Chemistry. 9:367-376
Three polyether complexing agents were prepared whose shapes could be photochemically altered by means of an azobenzene fragment incorporated into the middle of the polyether chain. The compounds are 1, bis-4,4′-[2-(methoxyethoxy)acetamido]azobenze
Autor:
Joseph J. Cincotta, Paul Haberfield
Publikováno v:
The Journal of Organic Chemistry. 55:1334-1338
Comparaison de la cinetique d'aminolyse de l'hexanoate de p-nitrophenyle et de (CH 3 ) 3 N + CH 2 CH 2 CH 2 COOC 6 H 4 p−NO 2 , par la benzylamine et − O 3 SCH 2 CH 2 NH 2
Autor:
Paul Haberfield
Publikováno v:
Structural Chemistry. 1:133-136
The anesthetic efficiencies of seven hydroxybenzyl alcohols were found to correlate well with their entropies of hydration. The correlation with lipid solubility was poor. This is taken to mean that the site of activity of these aspirin-like substanc
Autor:
Nathan Strick, Neurath Alexander Robert, Paul Haberfield, Shibo Jiang, Kang Lin, Asim K. Debnath
Publikováno v:
Journal of medicinal chemistry. 37(8)
Using comparative molecular field analysis (CoMFA), a 3D-QSAR model was developed for 21 porphyrin derivatives which have anti-HIV-1 activity and bind to the V3 loop of the envelope glycoprotein gp120 of the human immunodeficiency virus type 1. A sig
Autor:
Paul Haberfield
Publikováno v:
Journal of the American Chemical Society. 117:3314-3315