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Akademický článek

L- and V-curves for optimal smoothing.

Autor: Frasso, Gianluca¹, Eilers, Paul HC²

Publikováno v: Statistical Modelling: An International Journal. Feb2015, Vol. 15 Issue 1, p91-111. 21p.

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Akademický článek

Quantile regression for the statistical analysis of immunological data with many non-detects

Autor: Eilers Paul HC, Röder Esther, Savelkoul Huub FJ, van Wijk Roy

Publikováno v: BMC Immunology, Vol 13, Iss 1, p 37 (2012)

Abstract Background Immunological parameters are hard to measure. A well-known problem is the occurrence of values below the detection limit, the non-detects. Non-detects are a nuisance, because classical statistical analyses, like ANOVA and regressi

Externí odkaz: https://doaj.org/article/ae38a62433784506945958fe78c60146

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Akademický článek

An R package 'VariABEL' for genome-wide searching of potentially interacting loci by testing genotypic variance heterogeneity

Autor: Struchalin Maksim V, Amin Najaf, Eilers Paul HC, van Duijn Cornelia M, Aulchenko Yurii S

Publikováno v: BMC Genetics, Vol 13, Iss 1, p 4 (2012)

Abstract Background Hundreds of new loci have been discovered by genome-wide association studies of human traits. These studies mostly focused on associations between single locus and a trait. Interactions between genes and between genes and environm

Externí odkaz: https://doaj.org/article/2cd207dce06346f29f8b8b3c15011227

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Akademický článek

MLPAinter for MLPA interpretation: an integrated approach for the analysis, visualisation and data management of Multiplex Ligation-dependent Probe Amplification

Autor: Morreau Hans, Cleton-Jansen Anne-Marie, Natté Remco, Eilers Paul HC, van Eijk Ronald, van Wezel Tom, Oosting Jan

Publikováno v: BMC Bioinformatics, Vol 11, Iss 1, p 67 (2010)

Abstract Background Multiplex Ligation-Dependent Probe Amplification (MLPA) is an application that can be used for the detection of multiple chromosomal aberrations in a single experiment. In one reaction, up to 50 different genomic sequences can be

Externí odkaz: https://doaj.org/article/2cc67ea1e4214ae6a0a6eccf33f48bb5

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GWAS with longitudinal phenotypes: performance of approximate procedures

Autor: Sikorska, Karolina, Mostafavi, Nahid, Uitterlinden, André, Rivadeneira, Fernando, Eilers, Paul HC, Lesaffre, Emmanuel, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, LS IRAS EEPI ME (Milieu epidemiologie)

Publikováno v: European Journal of Human Genetics, 23(10), 1384-1391. Nature Publishing Group
European Journal of Human Genetics, 23. Nature Publishing Group

Analysis of genome-wide association studies with longitudinal data using standard procedures, such as linear mixed model (LMM) fitting, leads to discouragingly long computation times. There is a need to speed up the computations significantly. In our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ae3b9d608a8a9f0de8a8b809c81a0d
https://doi.org/10.1038/ejhg.2015.1

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Akademický článek

Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis

Autor: Eilers Paul HC, van de Velde Cornelis, Karsten Tom, de Miranda Noel FCC, Oosting Jan, de Graaf Eelco JR, van Eijk Ronald, Lips Esther H, Tollenaar Rob AEM, van Wezel Tom, Morreau Hans

Publikováno v: BMC Cancer, Vol 8, Iss 1, p 314 (2008)

Abstract Background Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could distinguish adenoma from carcinoma tissue and that gain

Externí odkaz: https://doaj.org/article/0f2a8a8c8ead46d6914e3a878055af42

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Akademický článek

Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles

Autor: Medema Jan, van Krieken J Han JM, Marijnen Corrie AM, van Wezel Tom, Lombaerts Marcel, van der Zee Minke MC, van Eijk Ronald, Lips Esther H, van de Pas Simone, de Bruin Elza C, van de Velde Cornelis JH, Eilers Paul HC, Peltenburg Lucy TC

Publikováno v: BMC Genomics, Vol 6, Iss 1, p 142 (2005)

Abstract Background The molecular determinants of carcinogenesis, tumor progression and patient prognosis can be deduced from simultaneous comparison of thousands of genes by microarray analysis. However, the presence of stroma cells in surgically ex

Externí odkaz: https://doaj.org/article/bf045e47a4ac4009a5e5edf52a1a1d32

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Akademický článek

Discussion: The beauty of expectiles.

Autor: Eilers, Paul HC¹

Publikováno v: Statistical Modelling: An International Journal. Aug2013, Vol. 13 Issue 4, p317-322. 6p. 1 Chart.

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