Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Paul H.M. Lohman"'
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 496:1-4
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. :37-50
The induction of double-strand breaks (DSBs) in DNA by exposure to DNA damaging agents or as intermediates in normal cellular processes, creates a severe threat for the integrity of the genome. Unrepaired or incorrectly repaired DSBs lead to broken c
Autor:
Albert Pastink, Michael van den Bosch, José B. M. Zonneveld, Paul H.M. Lohman, Marcel Lombaerts, Jourica A. Brandsma, Johanne M. Murray, Kees Vreeken
Publikováno v:
Mutation Research/DNA Repair. 461:311-323
The RAD52 gene of Saccharomyces cerevisiae is essential for repair of DNA double-strand breaks (DSBs) by homologous recombination. Inactivation of this gene confers hypersensitivity to DSB-inducing agents and defects in most forms of recombination. T
Autor:
Nicolaas G. J. Jaspers, Maria Kraakman-van der Zwet, Wilhelmina J. I. Overkamp, A.T. Natarajan, Małgorzata Z. Zdzienicka, Paul H.M. Lohman
Publikováno v:
Mutation Research-Dna Repair, 485, 177-185. Elsevier
Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) are rare autosomal recessive hereditary disorders characterized by radiosensitivity, chromosomal instability, immunodeficiency and proneness to cancer. Although the clinical features of
Publikováno v:
Proceedings of the National Academy of Sciences. 97:8403-8408
Somatic mutation accumulation has been implicated as a major cause of cancer and aging. By using a transgenic mouse model with a chromosomally integrated lacZ reporter gene, mutational spectra were characterized at young and old age in two organs gre
Publikováno v:
Molecular and Cellular Biology. 19:6269-6275
The RAD54 gene has an essential role in the repair of double-strand breaks (DSBs) via homologous recombination in yeast as well as in higher eukaryotes. A Drosophila melanogaster strain deficient in the RAD54 homolog DmRAD54 is characterized by incre
Autor:
Nicolaas G. J. Jaspers, Alina T. Midro, Friederike Eckardt-Schupp, Paul H.M. Lohman, Wilhelmina J. I. Overkamp, B. Klein, Maria Kraakman-van der Zwet, Anna A. Friedl, G. W. C. T. Verhaegh, Małgorzata Z. Zdzienicka
Publikováno v:
ResearcherID
Mutation Research, 14(434(1)), 17-27
Mutation Research, 14(434(1)), 17-27
Nijmegen Breakage Syndrome (NBS) is a very rare autosomal recessive chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency and a high incidence of malignancies. Cells from NBS patients are hypersensitive
Autor:
Petra P. H. Van Sloun, Paul H.M. Lohman, Jacob G. Jansen, Geert Weeda, Harry Vrieling, Albert A. van Zeeland, Leon H.F. Mullenders
Publikováno v:
Nucleic Acids Research, 27(16), 3276-3282. Oxford University Press
In this study the role of nucleotide excision repair (NER) in protecting mouse embryonic stem (ES) cells against the genotoxic effects of UV-photolesions was analysed. Repair of cyclobutane pyrimidine dimers (CPD) in transcribed genes could not be de
Autor:
Marius J. Giphart, Paul H.M. Lohman, Arnolda G. de Nooij-van Dalen, Micheline Giphart-Gassler
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 423:1-10
Loss of heterozygosity (LOH) contributes significantly to the inactivation of tumor suppressor genes and may involve a variety of mechanisms. Studying loss of HLA-A2 alleles in human lymphoblastoid cell lines, we previously showed that mitotic recomb
Autor:
Petra P. H. Van Sloun, Albert Pastink, Tonnie Rijkers, Willy M. Baarends, Bruno Morolli, Jody Van Den Ouweland, A. Rolink, Paul H.M. Lohman
Publikováno v:
Molecular and Cellular Biology, 18(11), 6423-6429. American Society for Microbiology
The RAD52 epistasis group is required for recombinational repair of double-strand breaks (DSBs) and shows strong evolutionary conservation. In Saccharomyces cerevisiae, RAD52 is one of the key members in this pathway. Strains with mutations in this g