Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Paul H.M. Lohman"'
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 496:1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b2e3a8fae094c49deefa4922878bc6f
https://doi.org/10.1016/s1383-5718(01)00226-1
https://doi.org/10.1016/s1383-5718(01)00226-1
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. :37-50
The induction of double-strand breaks (DSBs) in DNA by exposure to DNA damaging agents or as intermediates in normal cellular processes, creates a severe threat for the integrity of the genome. Unrepaired or incorrectly repaired DSBs lead to broken c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb402c4f49129433692c46f6ee70980
https://doi.org/10.1016/s0027-5107(01)00167-1
https://doi.org/10.1016/s0027-5107(01)00167-1
Autor:
Albert Pastink, Michael van den Bosch, José B. M. Zonneveld, Paul H.M. Lohman, Marcel Lombaerts, Jourica A. Brandsma, Johanne M. Murray, Kees Vreeken
Publikováno v:
Mutation Research/DNA Repair. 461:311-323
The RAD52 gene of Saccharomyces cerevisiae is essential for repair of DNA double-strand breaks (DSBs) by homologous recombination. Inactivation of this gene confers hypersensitivity to DSB-inducing agents and defects in most forms of recombination. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484bb6326b5d1dc87a631101fad1bca6
https://doi.org/10.1016/s0921-8777(00)00060-4
https://doi.org/10.1016/s0921-8777(00)00060-4
Autor:
Nicolaas G. J. Jaspers, Maria Kraakman-van der Zwet, Wilhelmina J. I. Overkamp, A.T. Natarajan, Małgorzata Z. Zdzienicka, Paul H.M. Lohman
Publikováno v:
Mutation Research-Dna Repair, 485, 177-185. Elsevier
Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) are rare autosomal recessive hereditary disorders characterized by radiosensitivity, chromosomal instability, immunodeficiency and proneness to cancer. Although the clinical features of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c47d445b0912a2e4006f73d10342233
https://doi.org/10.1016/s0921-8777(00)00078-1
https://doi.org/10.1016/s0921-8777(00)00078-1
Publikováno v:
Proceedings of the National Academy of Sciences. 97:8403-8408
Somatic mutation accumulation has been implicated as a major cause of cancer and aging. By using a transgenic mouse model with a chromosomally integrated lacZ reporter gene, mutational spectra were characterized at young and old age in two organs gre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be281f54e843ebefd4e01e36692c3fb2
https://doi.org/10.1073/pnas.97.15.8403
https://doi.org/10.1073/pnas.97.15.8403
Autor:
Nicolaas G. J. Jaspers, Alina T. Midro, Friederike Eckardt-Schupp, Paul H.M. Lohman, Wilhelmina J. I. Overkamp, B. Klein, Maria Kraakman-van der Zwet, Anna A. Friedl, G. W. C. T. Verhaegh, Małgorzata Z. Zdzienicka
Publikováno v:
ResearcherID
Mutation Research, 14(434(1)), 17-27
Mutation Research, 14(434(1)), 17-27
Nijmegen Breakage Syndrome (NBS) is a very rare autosomal recessive chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency and a high incidence of malignancies. Cells from NBS patients are hypersensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da67637867367a48f29fbac525cf93e6
https://pure.eur.nl/en/publications/b5fa379b-c735-4b11-9a3f-a54e664f02c7
https://pure.eur.nl/en/publications/b5fa379b-c735-4b11-9a3f-a54e664f02c7
Autor:
Marius J. Giphart, Paul H.M. Lohman, Arnolda G. de Nooij-van Dalen, Micheline Giphart-Gassler
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 423:1-10
Loss of heterozygosity (LOH) contributes significantly to the inactivation of tumor suppressor genes and may involve a variety of mechanisms. Studying loss of HLA-A2 alleles in human lymphoblastoid cell lines, we previously showed that mitotic recomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6598fca6a9eb1776e0647c8b0630a7a1
https://doi.org/10.1016/s0027-5107(98)00204-8
https://doi.org/10.1016/s0027-5107(98)00204-8
Autor:
Petra P. H. Van Sloun, Albert Pastink, Tonnie Rijkers, Willy M. Baarends, Bruno Morolli, Jody Van Den Ouweland, A. Rolink, Paul H.M. Lohman
Publikováno v:
Molecular and Cellular Biology, 18(11), 6423-6429. American Society for Microbiology
The RAD52 epistasis group is required for recombinational repair of double-strand breaks (DSBs) and shows strong evolutionary conservation. In Saccharomyces cerevisiae, RAD52 is one of the key members in this pathway. Strains with mutations in this g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778b5d08db434438de237658a4d0e611
https://doi.org/10.1128/mcb.18.11.6423
https://doi.org/10.1128/mcb.18.11.6423
Autor:
Micheline Giphart-Gassler, Paul H.M. Lohman, Vera H. A. van Buuren-van Seggelen, Arnolda G. de Nooij-van Dalen
Publikováno v:
Genes, Chromosomes and Cancer. 21:30-38
Loss of heterozygosity (LOH) plays an important role in the expression of recessive mutations in mammalian cells. To gain insight into the rate and mechanisms of LOH the autosomal HLA-A gene was used as a model system. Spontaneous HLA-A2 mutants orig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9647c220bd01e2d21d2115145685cf5
https://doi.org/10.1002/(sici)1098-2264(199801)21:1<30::aid-gcc5>3.0.co
https://doi.org/10.1002/(sici)1098-2264(199801)21:1<30::aid-gcc5>3.0.co
Autor:
Harry Vrieling, Hanneke J. M. Kool, Susan W.P. Wijnhoven, Paul H.M. Lohman, Albert A. van Zeeland, Geert Weeda, Petra P. H. Van Sloun, Rosalyn Slater
Publikováno v:
Proceedings of the National Academy of Sciences of the U.S.A., 95, 13759-13764. National Academy of Sciences
Genetic events leading to the loss of heterozygosity (LOH) have been shown to play a crucial role in the development of cancer. However, LOH events do not occur only in genetically unstable cancer cells but also have been detected in normal somatic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc7477c60c23450f01b978805e36545
https://doi.org/10.1073/pnas.95.23.13759
https://doi.org/10.1073/pnas.95.23.13759