Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Paul H.A. Quax"'
Autor:
Eva van Ingen, Pleun A.M. Engbers, Tamar Woudenberg, M. Leontien van der Bent, Hailiang Mei, Johann Wojta, Paul H.A. Quax, A. Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 162-172 (2022)
C/D box small nucleolar RNAs (snoRNAs) of the DLK1-DIO3 locus are associated with vascular remodeling and cardiovascular disease. None of these snoRNAs has any known targets yet except for one, AF357425/SNORD113-6. We previously showed that this snoR
Externí odkaz:
https://doaj.org/article/611b5447849f4d83868b5251b99cc594
Autor:
Hugo Fernandes, Alessandra Zonnari, Ricardo Abreu, Sezin Aday, Marta Barão, Inês Albino, Miguel Lino, Ana Branco, Cátia Seabra, Tânia Barata, Ermelindo C. Leal, José Guilherme Tralhão, Lino Gonçalves, Alwin de Jong, Hendrika A.B. Peters, Margreet R. de Vries, Paula da Costa Martins, Paul H.A. Quax, Lino Ferreira
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 307-327 (2022)
Endothelial cell (EC) activity is essential for tissue regeneration in several (patho)physiological contexts. However, our capacity to deliver in vivo biomolecules capable of controlling EC fate is relatively limited. Here, we screened a library of m
Externí odkaz:
https://doaj.org/article/75ed63aad54641e397aa0c2c69a05474
Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia
Autor:
Reginald V.C.T. van der Kwast, Laura Parma, M. Leontien van der Bent, Eva van Ingen, Fabiana Baganha, Hendrika A.B. Peters, Eveline A.C. Goossens, Karin H. Simons, Meindert Palmen, Margreet R. de Vries, Paul H.A. Quax, A. Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 932-953 (2020)
Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs’ targetomes and thus their function. Using public RNA-sequencing data, we identified 35 vasoactive microRNAs that are A-to-I edited. We quantified A-to-
Externí odkaz:
https://doaj.org/article/2209272f4f534aa0b0f07a3770ab3c50
Autor:
Eva van Ingen, Amanda C. Foks, Mara J. Kröner, Johan Kuiper, Paul H.A. Quax, Ilze Bot, Anne Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 638-649 (2019)
We have previously shown that third-generation antisense (3GA) inhibition of 14q32 microRNA (miRNA)-494 reduced early development of atherosclerosis. However, patients at risk of atherosclerotic complications generally present with advanced and unsta
Externí odkaz:
https://doaj.org/article/c0ecfbcecf4a4e57b8835ececd858d65
Autor:
Angela Downie Ruiz Velasco, Sabine M.J. Welten, Eveline A.C. Goossens, Paul H.A. Quax, Juri Rappsilber, Gracjan Michlewski, A. Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 329-338 (2019)
After induction of ischemia in mice, 14q32 microRNAs are regulated in three distinct temporal patterns. These expression patterns, as well as basal expression levels, are independent of the microRNA genes’ order in the 14q32 locus. This implies tha
Externí odkaz:
https://doaj.org/article/49355aa60c26423686622c16118da574
Autor:
Nigel G. Kooreman, Patricia E. de Almeida, Jonathan P. Stack, Raman V. Nelakanti, Sebastian Diecke, Ning-Yi Shao, Rutger-Jan Swijnenburg, Veronica Sanchez-Freire, Elena Matsa, Chun Liu, Andrew J. Connolly, Jaap F. Hamming, Paul H.A. Quax, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Joseph C. Wu
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1978-1990 (2017)
There is growing interest in using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of human immune responses to stem cell-derived allografts is necessary for
Externí odkaz:
https://doaj.org/article/0a8eda0aa02542dc8e7d00ecadd53956
Autor:
Sabine M.J. Welten, Margreet R. de Vries, Erna A.B. Peters, Sudhir Agrawal, Paul H.A. Quax, A. Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 61-70 (2017)
Improving the efficacy of neovascularization is a promising strategy to restore perfusion of ischemic tissues in patients with peripheral arterial disease. The 14q32 microRNA cluster is highly involved in neovascularization. The Mef2a transcription f
Externí odkaz:
https://doaj.org/article/48bd5bf3a40c4a77a2a7816f7de54a77
Autor:
Laura Parma, Hendrika A.B. Peters, Maria E. Johansson, Saray Gutiérrez, Henk Meijerink, Sjef de Kimpe, Margreet R. de Vries, Paul H.A. Quax
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 13, p 4643 (2020)
VEGFR2 and VEGF-A play a pivotal role in the process of angiogenesis. VEGFR2 activation is regulated by protein tyrosine phosphatases (PTPs), enzymes that dephosphorylate the receptor and reduce angiogenesis. We aim to study the effect of PTPs blocka
Externí odkaz:
https://doaj.org/article/b30955f306f94ab493720e284a4e575d
Autor:
Eveline A.C. Goossens, Margreet R. de Vries, J. Wouter Jukema, Paul H.A. Quax, A. Yaël Nossent
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3508 (2020)
Myostatin is a negative regulator of muscle cell growth and proliferation. Furthermore, myostatin directly affects the expression of 14q32 microRNAs by binding the 14q32 locus. Direct inhibition of 14q32 microRNA miR-495-3p decreased postintervention
Externí odkaz:
https://doaj.org/article/c67ccd002e4844bf8ebb5ece2538e5ac
Autor:
Laura Parma, Hendrika A. B. Peters, Fabiana Baganha, Judith C. Sluimer, Margreet R. de Vries, Paul H.A. Quax
Publikováno v:
Cells, Vol 9, Iss 2, p 336 (2020)
Unstable atherosclerotic plaques frequently show plaque angiogenesis which increases the chance of rupture and thrombus formation leading to infarctions. Hypoxia plays a role in angiogenesis and inflammation, two processes involved in the pathogenesi
Externí odkaz:
https://doaj.org/article/5bcbb7e8cfaf4086aae1479c464c9d71