Výsledky vyhledávání - "Paul H. Weinreb"

Akademický článek

Characterization of tau binding by gosuranemab

Autor: Richelle Sopko, Olga Golonzhka, Joseph Arndt, Chao Quan, Julie Czerkowicz, Andrew Cameron, Benjamin Smith, Yogapriya Murugesan, Garrett Gibbons, Soo-Jung Kim, John Q. Trojanowski, Virginia M.Y. Lee, Kurt R. Brunden, Danielle L. Graham, Paul H. Weinreb, Heike Hering

Publikováno v: Neurobiology of Disease, Vol 146, Iss , Pp 105120- (2020)

Deposition of tau aggregates in the brain is a pathological hallmark of several neurodegenerative diseases, termed tauopathies, such as Alzheimer's disease (AD), corticobasal degeneration, and progressive supranuclear palsy (PSP). As transcellular sp

Externí odkaz: https://doaj.org/article/8601fbe561424bea9b0eeb1ca6a1160a

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Akademický článek

The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis

Autor: Shiv Ram Krishn, Israa Salem, Fabio Quaglia, Nicole M. Naranjo, Ekta Agarwal, Qin Liu, Srawasti Sarker, Jessica Kopenhaver, Peter A. McCue, Paul H. Weinreb, Shelia M. Violette, Dario C. Altieri, Lucia R. Languino

Publikováno v: Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)

Prostate cancer (PrCa) cells crosstalk with the tumour microenvironment by releasing small extracellular vesicles (sEVs). sEVs, as well as large extracellular vesicles (LEVs), isolated via iodixanol density gradients from PrCa cell culture media, exp

Externí odkaz: https://doaj.org/article/bd1b27636456482fba3d34cdb9721249

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Akademický článek

Inhibition of integrin αVβ6 changes fibril thickness of stromal collagen in experimental carcinomas

Autor: P. Olof Olsson, Renata Gustafsson, Alexei V. Salnikov, Maria Göthe, Kathrin S. Zeller, Tomas Friman, Bo Baldetorp, Louise A. Koopman, Paul H. Weinreb, Shelia M. Violette, Sebastian Kalamajski, Nils-Erik Heldin, Kristofer Rubin

Publikováno v: Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-11 (2018)

Abstract Background Chemotherapeutic efficacy can be improved by targeting the structure and function of the extracellular matrix (ECM) in the carcinomal stroma. This can be accomplished by e.g. inhibiting TGF-β1 and -β3 or treating with Imatinib,

Externí odkaz: https://doaj.org/article/fe3d1f86aca84e059d01cd634fae0c7c

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Akademický článek

Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration

Autor: Qin Wang, Luisette Delva, Paul H. Weinreb, Robert B. Pepinsky, Danielle Graham, Elvana Veizaj, Anne E. Cheung, Weiping Chen, Ivan Nestorov, Ellen Rohde, Robin Caputo, Geoffrey M. Kuesters, Tonika Bohnert, Liang-Shang Gan

Publikováno v: Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-10 (2018)

Abstract Background Many studies have focused on the challenges of small molecule uptake across the blood–brain barrier, whereas few in-depth studies have assessed the challenges with the uptake of antibodies into the central nervous system (CNS).

Externí odkaz: https://doaj.org/article/d36a79f39c3e4673962d0976b38bc14c

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Akademický článek

Fibronectin-guided migration of carcinoma collectives

Autor: Sandeep Gopal, Laurence Veracini, Dominique Grall, Catherine Butori, Sébastien Schaub, Stéphane Audebert, Luc Camoin, Emilie Baudelet, Agata Radwanska, Stéphanie Beghelli-de la Forest Divonne, Shelia M. Violette, Paul H. Weinreb, Samah Rekima, Marius Ilie, Anne Sudaka, Paul Hofman, Ellen Van Obberghen-Schilling

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Tumour microenvironment influences the migration of cancer cells. Here the authors analyse the proteomic constitution of the extracellular matrix and identify a role for fibronectin in regulating the collective migration of squamous cell carcinoma ce

Externí odkaz: https://doaj.org/article/73eecdf36c934aa6a3a90e0aae76a253

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