Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Paul H. Slagle"'
Autor:
Caroline Hebert, Steven J. Shire, Jun Liu, Rhona C. Kabakoff, Henry B. Lowman, Paul H. Slagle, Wayne J. Fairbrother
Publikováno v:
Protein Science. 6:598-608
IL-8 dimers have been observed in NMR and X-ray structures of the protein. We have engineered IL-8 monomers by mutations of residues throughout the dimer interface, which introduce hindrance determinants to dimerization. These IL-8 variants are shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8309f9adbeb0f43bdc48562ec4258974
https://doi.org/10.1002/pro.5560060309
https://doi.org/10.1002/pro.5560060309
Autor:
Wayne J. Fairbrother, James H. Bourell, Beth L. Gillece-Castro, Laura DeForge, Paul H. Slagle, Henry B. Lowman, Cynthia M. Wirth
Publikováno v:
The Journal of biological chemistry. 271(24)
Interleukin-8 (IL-8), a CXC chemokine, is known to bring about chemotaxis and activation of neutrophils through high affinity binding to at least two distinct receptors, receptor-A and receptor-B. The IL-8 homolog melanoma growth stimulating activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4a2be78515fc114029a733d6c499d7
https://pubmed.ncbi.nlm.nih.gov/8662882
https://pubmed.ncbi.nlm.nih.gov/8662882