Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Paul H. M. Kullmann"'
Autor:
Paul H. M. Kullmann, John P. Horn
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Neurons in paravertebral sympathetic ganglia are innervated by converging nicotinic synapses of varying strength. Based upon intracellular recordings of excitatory postsynaptic potentials (EPSPs) with sharp microelectrodes these synapses were classif
Externí odkaz:
https://doaj.org/article/fabaf0cf0d644c4f9c5ca8318409a131
Publikováno v:
The Journal of Physiology. 593:803-823
Key points The synaptic organization of paravertebral sympathetic ganglia enables them to relay activity from the spinal cord to the periphery and thereby control autonomic functions, including blood pressure and body temperature. The present experim
Autor:
Margaret A. Twomey, Jayalakshmi Miriyala, Mark J. Zylka, Angela M. Mabb, Benjamin D. Philpot, Paul H. M. Kullmann
Publikováno v:
Proceedings of the National Academy of Sciences. 111:17290-17295
Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that topotecan reduces the expression of multiple long genes, including many neuronal genes linked to synapses and autism. However, wheth
Autor:
Elias Aizenman, Karen A. Hartnett, Kai He, Paul H. M. Kullmann, Ilana Lotan, John P. Horn, Meghan C. McCord
Publikováno v:
The Journal of Physiology. 592:3511-3521
Key points K+ efflux through newly membrane-inserted voltage-gated Kv2.1 K+ channels precedes neuronal apoptosis. In this study, we show that the binding site of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protei
Autor:
Irene Arduini, K. Lyles Clark, Mitchell G. Springer, John P. Horn, K.M. Sikora, Paul H. M. Kullmann
The influence of hyperpolarization-activated cation current (h-current; Ih) upon synaptic integration in paravertebral sympathetic neurons was studied together with expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) subunit isofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf5a9a6b7978725b6349ecad4972fd3
https://europepmc.org/articles/PMC4976122/
https://europepmc.org/articles/PMC4976122/
Autor:
John P. Horn, Paul H. M. Kullmann
Publikováno v:
Autonomic Neuroscience. 155:19-24
We compared the excitability of secretomotor B and vasomotor C neurons using virtual nicotinic synapses implemented with the dynamic clamp technique. In response to fast synaptic conductance (gsyn) waveforms modeled after B cell synaptic currents, it
Autor:
John P. Horn, Paul H. M. Kullmann
Publikováno v:
The Journal of Physiology. 588:923-938
We compared how vasomotor C neurons and secretomotor B neurons integrated identical patterns of virtual synaptic activity using dynamic clamp, perforated-patch recordings from dissociated bullfrog sympathetic ganglion cells. The synaptic template mod
Publikováno v:
The Journal of Neuroscience. 29:15414-15419
Cav1.3 (α1D) L-type Ca2+channels have been implicated in substantia nigra (SN) dopamine (DA) neuron pacemaking and vulnerability to Parkinson's disease. These effects may arise from the depolarizing current and cytoplasmic Ca2+elevation produced by
Publikováno v:
Journal of Neurophysiology. 101:926-933
Midbrain dopamine neuron activity results from the integration of the responses to metabo- and ionotropic receptors with the postsynaptic excitability of these intrinsic pacemakers. Interestingly, intrinsic pacemaker rate varies greatly between indiv
Autor:
Karl Kandler, Paul H. M. Kullmann
Publikováno v:
Neuroscience. 154:338-345
During development, GABA/glycinergic connections from the medial nucleus of the trapezoid body (MNTB) to the lateral superior olive (LSO) gradually change from being depolarizing to being hyperpolarizing. Previous studies have shown that depolarizing