Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Paul H. Kim"'
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTThe Lmna knockout mouse (Lmna–/–) created by Sullivan and coworkers in 1999 has been widely used to examine lamin A/C function. The knockout allele contains a deletion of Lmna intron 7–exon 11 sequences and was reported to be a null all
Externí odkaz:
https://doaj.org/article/a37af6463c93485393def069c89f5750
Autor:
Patrick J. Heizer, Ye Yang, Yiping Tu, Paul H. Kim, Natalie Y. Chen, Yan Hu, Yuko Yoshinaga, Pieter J. de Jong, Laurent Vergnes, Jazmin E. Morales, Robert L. Li, Nicholas Jackson, Karen Reue, Stephen G. Young, Loren G. Fong
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 413-421 (2020)
Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity
Externí odkaz:
https://doaj.org/article/13a63de43af34811a3f699cc04d6c57d
Publikováno v:
Nucleus, Vol 11, Iss 1, Pp 237-249 (2020)
The nuclear membranes function as a barrier to separate the cell nucleus from the cytoplasm, but this barrier can be compromised by nuclear membrane ruptures, leading to intermixing of nuclear and cytoplasmic contents. Spontaneous nuclear membrane ru
Externí odkaz:
https://doaj.org/article/4cb55d56a0a941d7b14f8d53e39ae9db
Autor:
Paul H. Kim, Natalie Y. Chen, Patrick J. Heizer, Yiping Tu, Thomas A. Weston, Jared L.-C. Fong, Navjot Kaur Gill, Amy C. Rowat, Stephen G. Young, Loren G. Fong
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The mutant nuclear lamin protein (progerin) produced in Hutchinson-Gilford progeria syndrome (HGPS) results in loss of arterial smooth muscle cells (SMCs), but the mechanism has been unclear. We found that progerin induces repetitive nuclear membrane
Externí odkaz:
https://doaj.org/article/782e92b7c80f4e82b3a9551cf8e5b14f
Autor:
Navjot Kaur Gill, Chau Ly, Paul H. Kim, Cosmo A. Saunders, Loren G. Fong, Stephen G. Young, G. W. Gant Luxton, Amy C. Rowat
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
DYT1 dystonia is a neurological movement disorder that is caused by a loss-of-function mutation in the DYT1/TOR1A gene, which encodes torsinA, a conserved luminal ATPases-associated with various cellular activities (AAA+) protein. TorsinA is required
Externí odkaz:
https://doaj.org/article/c2dcad65b8cd4da7bc906f93dd58d0ab
Publikováno v:
Global Spine Journal
Study Design Case report. Objective We report a case of spontaneous atlantoaxial rotatory fixation (AARF) presenting 9 months after onset in an 11-year-old boy. Methods This is a retrospective case report of spontaneous ankylosis of occiput to C2 fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43fe9a3bcf05ecc97d39ba6ccf09f32
https://doi.org/10.1055/s-0035-1549432
https://doi.org/10.1055/s-0035-1549432
Autor:
Seth S. Leopold, Paul H. Kim
Publikováno v:
Clinical Orthopaedics & Related Research. 477:2388-2388
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda84bb496d52f2ef0d8e7153f6896e4
https://doi.org/10.1097/corr.0000000000000950
https://doi.org/10.1097/corr.0000000000000950
Publikováno v:
Cancer Research. 79:587-587
Meta-analyses consistently show that postmenopausal women with elevated levels of estradiol have an increased risk for certain cancers, such as breast cancer. At the same time, estradiol therapy is used to treat menopausal symptoms. Data on blood lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aff5193fe604f87c0947be0f9b6e637
https://doi.org/10.1158/1538-7445.am2019-587
https://doi.org/10.1158/1538-7445.am2019-587
Autor:
Seth S. Leopold, Paul H. Kim
Publikováno v:
Clinical Orthopaedics & Related Research. 470:3270-3274
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02cdc7c89bcda6499ba23ca7be4e6f6c
https://doi.org/10.1007/s11999-012-2376-6
https://doi.org/10.1007/s11999-012-2376-6
Autor:
Paul H. Kim, Deborah Money, Mark Gilbert, Michael Chang, Rafael Meza, Robert C. Brunham, Michael L. Rekart
Publikováno v:
The Journal of Infectious Diseases. 207:30-38
Background. Many countries have witnessed a disturbing increase in cases of Chlamydia trachomatis infection despite enhanced control programs. Since the goal of Chlamydia control is to prevent reproductive complications such as pelvic inflammatory di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232e9dc7f46d51aa9acb526d46022d95
https://doi.org/10.1093/infdis/jis644
https://doi.org/10.1093/infdis/jis644