Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Paul H. Bernardo"'
Publikováno v:
Synlett. 2007:1935-1939
An efficient synthesis of the indolo[3,2- J]phenanthridine alkaloid calothrixin B is described. The relative ease and high yields of this synthesis make this an attractive route for the preparation of calothrixin B derivatives for structure-activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::308381543b528581f80be07017231d33
https://doi.org/10.1055/s-2007-984520
https://doi.org/10.1055/s-2007-984520
Synthesis, Electrochemistry, and Bioactivity of the Cyanobacterial Calothrixins and Related Quinones
Autor:
Graham A. Heath, Geoffrey D. Smith, Paul Waring, Paul H. Bernardo, Peter J. Mahon, Christina L. L. Chai, Bronwyn A. Wilkes
Publikováno v:
Journal of Medicinal Chemistry. 47:4958-4963
The calothrixins are quinone-based natural products isolated from Calothrix cyanobacteria which show potent antiproliferative properties against several cancer cell lines. Preliminary mechanistic studies suggest that the biological mode of action of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817398e6eacab33a89cc2ce56a7df73b
https://doi.org/10.1021/jm049625o
https://doi.org/10.1021/jm049625o
Autor:
Paul H. Bernardo, Christina L. L. Chai
Publikováno v:
The Journal of Organic Chemistry. 68:8906-8909
The total syntheses of calothrixins A and B starting from readily available indole and the acid chloride 4 are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1d6f378056b36f5891c5217a36796c
https://doi.org/10.1021/jo035049c
https://doi.org/10.1021/jo035049c
Publikováno v:
Tetrahedron Letters. 52:92-94
A series of 8-anilino and 9-anilinophenanthridine-7,10-diones was prepared and screened against various cancer cell lines to measure anti-proliferative activity. The compounds tested display potent cytotoxic activity in the micromolar and sub-micromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3acade7126b3e562ef4d033c720f2d2
https://doi.org/10.1016/j.tetlet.2010.10.170
https://doi.org/10.1016/j.tetlet.2010.10.170
Autor:
Eric Tam, Choon Boon Cheong, Vikrant A. Adsool, Yi Ling Goh, Paul H. Bernardo, Anthony D. William, Charles W. Johannes
Publikováno v:
ChemInform. 45
A novel one-pot two-step approach allows the conversion of iodo substituted azide (I) into the target amine (II) on multigram scale.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c6e59d567dfcea442f8cc79f44af89f
https://doi.org/10.1002/chin.201437069
https://doi.org/10.1002/chin.201437069
Autor:
Yi Ling Goh, Anthony D. William, Eric Tam, Choon Boon Cheong, Vikrant A. Adsool, Charles W. Johannes, Paul H. Bernardo
Publikováno v:
Organic letters. 16(7)
From a medicinal chemistry perspective, bicyclo[1.1.1]pentan-1-amine (1) has served as a unique and important moiety. Synthetically, however, this compound has received little attention, and only one scalable route to this amine has been demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1540de84626a2e5c09e9cc5909c5ed
https://pubmed.ncbi.nlm.nih.gov/24628135
https://pubmed.ncbi.nlm.nih.gov/24628135
Autor:
Paul H, Bernardo, Joo Chuan, Tong
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 800
Computational methods now play an integral role in modern drug discovery, and include the design and management of small molecule libraries, initial hit identification through virtual screening, optimization of the affinity and selectivity of hits, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35a5a60b0b2eec293c57a013a9dd9998
https://pubmed.ncbi.nlm.nih.gov/21964780
https://pubmed.ncbi.nlm.nih.gov/21964780
Autor:
Joo Chuan Tong, Paul H. Bernardo
Publikováno v:
Chemical Genomics and Proteomics ISBN: 9781617793486
Computational methods now play an integral role in modern drug discovery, and include the design and management of small molecule libraries, initial hit identification through virtual screening, optimization of the affinity and selectivity of hits, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db33f281f435f0a7ac0afe17a53b937d
https://doi.org/10.1007/978-1-61779-349-3_3
https://doi.org/10.1007/978-1-61779-349-3_3
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 685
CLEVER is a computational tool designed to support the creation, manipulation, enumeration, and visualization of combinatorial libraries. The system also provides a summary of the diversity, coverage, and distribution of selected compound collections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c273a27dfb8d0d5689d8bebfa9eb825
https://pubmed.ncbi.nlm.nih.gov/20981533
https://pubmed.ncbi.nlm.nih.gov/20981533
Publikováno v:
Methods in Molecular Biology ISBN: 9781607619307
CLEVER is a computational tool designed to support the creation, manipulation, enumeration, and visualization of combinatorial libraries. The system also provides a summary of the diversity, coverage, and distribution of selected compound collections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd976c4642e094a97fa59d660307ccde
https://doi.org/10.1007/978-1-60761-931-4_18
https://doi.org/10.1007/978-1-60761-931-4_18