Smoking-Associated Exposure of Human Primary Bronchial Epithelial Cells to Aldehydes: Impact on Molecular Mechanisms Controlling Mitochondrial Content and Function

Autor: Christy B. M. Tulen, Evert Duistermaat, Johannes W. J. M. Cremers, Walther N. M. Klerx, Paul H. B. Fokkens, Naömi Weibolt, Nico Kloosterboer, Mieke A. Dentener, Eric R. Gremmer, Phyllis J. J. Jessen, Evi J. C. Koene, Lou Maas, Antoon Opperhuizen, Frederik-Jan van Schooten, Yvonne C. M. Staal, Alexander H. V. Remels

Publikováno v: Cells, Vol 11, Iss 21, p 3481 (2022)

Chronic obstructive pulmonary disease (COPD) is a devastating lung disease primarily caused by exposure to cigarette smoke (CS). During the pyrolysis and combustion of tobacco, reactive aldehydes such as acetaldehyde, acrolein, and formaldehyde are f

Externí odkaz: https://doaj.org/article/2858f0d527984676b53f121e83d3e3b9

In Vitro Toxicity of Industrially Relevant Engineered Nanoparticles in Human Alveolar Epithelial Cells: Air–Liquid Interface versus Submerged Cultures

Autor: Maria João Bessa, Fátima Brandão, Paul H. B. Fokkens, Daan L. A. C. Leseman, A. John F. Boere, Flemming R. Cassee, Apostolos Salmatonidis, Mar Viana, Adriana Vulpoi, Simion Simon, Eliseo Monfort, João Paulo Teixeira, Sónia Fraga

Publikováno v: Nanomaterials, Vol 11, Iss 12, p 3225 (2021)

Diverse industries have already incorporated within their production processes engineered nanoparticles (ENP), increasing the potential risk of worker inhalation exposure. In vitro models have been widely used to investigate ENP toxicity. Air–liqui

Externí odkaz: https://doaj.org/article/862937ae12d043cb97329860ada6a1f1

Toxicity assessment of industrial engineered and airborne process-generated nanoparticles in a 3D human airway epithelial in vitro model

Autor: Apostolos Salmatonidis, Eliseo Monfort, Maria João Bessa, Sónia Fraga, Flemming R. Cassee, Adriana Vulpoi, Fátima Brandão, Mar Viana, Paul H. B. Fokkens, João Paulo Teixeira, Simion Simon

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nanotoxicology, 15(4), 542. Informa Healthcare

The advanced ceramic technology has been pointed out as a potentially relevant case of occupational exposure to nanoparticles (NP). Not only when nanoscale powders are being used for production, but also in the high-temperature processing of ceramic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb731596e078b3da75de4c27b0d970be

Exposure to acrolein disrupts the molecular regulation of mitochondrial metabolism in epithelial cells of the human airways

Autor: Paul H. B. Fokkens, E. Duistermaat, F.J. van Schooten, Yvonne C.M. Staal, N. Weibolt, Antoon Opperhuizen, Alexander Remels, Walther N M Klerx, Caspar Schiffers, Mieke A. Dentener, Hans W J M Cremers, C. van de Wetering, Niki L. Reynaert, Christy B. M. Tulen

Publikováno v: Toxicology Letters. 350:S167-S168

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aad5f1aa35bd7f091a313361588a5600
https://doi.org/10.1016/s0378-4274(21)00637-8

Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation

Autor: Patrick W. F. Hadoke, Nicholas A. Boon, Laura Flint, Ken Donaldson, Jon Beveridge, Anders Blomberg, Rodger Duffin, Mark R. Miller, Paul H. B. Fokkens, Flemming R. Cassee, David E. Newby, Nicholas L. Mills, Thomas Sandström, A. John F. Boere, Andrew J. Lucking

Publikováno v: Mills, N L, Miller, M R, Lucking, A J, Beveridge, J, Flint, L, Boere, A J F, Fokkens, P H, Boon, N A, Sandstrom, T, Blomberg, A, Duffin, R, Donaldson, K, Hadoke, P W F, Cassee, F R & Newby, D E 2011, ' Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation ', European Heart Journal, vol. 32, no. 21, pp. 2660-2671 . https://doi.org/10.1093/eurheartj/ehr195
European Heart Journal

AimExposure to road traffic and air pollution may be a trigger of acute myocardial infarction, but the individual pollutants responsible for this effect have not been established. We assess the role of combustion-derived-nanoparticles in mediating th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730add1768988f4a22afb572f0fbe368
https://doi.org/10.1093/eurheartj/ehr195