Smoking-Associated Exposure of Human Primary Bronchial Epithelial Cells to Aldehydes: Impact on Molecular Mechanisms Controlling Mitochondrial Content and Function

Autor: Christy B. M. Tulen, Evert Duistermaat, Johannes W. J. M. Cremers, Walther N. M. Klerx, Paul H. B. Fokkens, Naömi Weibolt, Nico Kloosterboer, Mieke A. Dentener, Eric R. Gremmer, Phyllis J. J. Jessen, Evi J. C. Koene, Lou Maas, Antoon Opperhuizen, Frederik-Jan van Schooten, Yvonne C. M. Staal, Alexander H. V. Remels

Publikováno v: Cells, Vol 11, Iss 21, p 3481 (2022)

Chronic obstructive pulmonary disease (COPD) is a devastating lung disease primarily caused by exposure to cigarette smoke (CS). During the pyrolysis and combustion of tobacco, reactive aldehydes such as acetaldehyde, acrolein, and formaldehyde are f

Externí odkaz: https://doaj.org/article/2858f0d527984676b53f121e83d3e3b9

In Vitro Toxicity of Industrially Relevant Engineered Nanoparticles in Human Alveolar Epithelial Cells: Air–Liquid Interface versus Submerged Cultures

Autor: Maria João Bessa, Fátima Brandão, Paul H. B. Fokkens, Daan L. A. C. Leseman, A. John F. Boere, Flemming R. Cassee, Apostolos Salmatonidis, Mar Viana, Adriana Vulpoi, Simion Simon, Eliseo Monfort, João Paulo Teixeira, Sónia Fraga

Publikováno v: Nanomaterials, Vol 11, Iss 12, p 3225 (2021)

Diverse industries have already incorporated within their production processes engineered nanoparticles (ENP), increasing the potential risk of worker inhalation exposure. In vitro models have been widely used to investigate ENP toxicity. Air–liqui

Externí odkaz: https://doaj.org/article/862937ae12d043cb97329860ada6a1f1

Optimization of an air-liquid interface

Autor: Rui-Wen, He, Hedwig M, Braakhuis, Rob J, Vandebriel, Yvonne C M, Staal, Eric R, Gremmer, Paul H B, Fokkens, Claudia, Kemp, Jolanda, Vermeulen, Remco H S, Westerink, Flemming R, Cassee

Publikováno v: Journal of Aerosol Science

Inhalation exposure to environmental and occupational aerosol contaminants is associated with many respiratory health problems. To realistically mimic long-term inhalation exposure for toxicity testing, lung epithelial cells need to maintained and ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a39ceb19f68cde1f2b61b408af533d7d
https://pubmed.ncbi.nlm.nih.gov/33658726

Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats

Autor: Ingeborg M. Kooter, Miriam E. Gerlofs-Nijland, A. John F. Boere, Daan L. A. C. Leseman, Paul H. B. Fokkens, Henri M. H. Spronk, Kim Frederix, Hugo ten Cate, Ad M. Knaapen, Hendrik J. Vreman, Flemming R. Cassee

Publikováno v: Journal of Toxicology, Vol 2010 (2010)

This study was designed to determine the sequence of events leading to cardiopulmonary effects following acute inhalation of diesel engine exhaust in rats. Rats were exposed for 2 h to diesel engine exhaust (1.9 mg/m3), and biological parameters rela

Externí odkaz: https://doaj.org/article/c9dde9cda6e14617a4d0d861124eb3ff

Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation

Autor: Patrick W. F. Hadoke, Nicholas A. Boon, Laura Flint, Ken Donaldson, Jon Beveridge, Anders Blomberg, Rodger Duffin, Mark R. Miller, Paul H. B. Fokkens, Flemming R. Cassee, David E. Newby, Nicholas L. Mills, Thomas Sandström, A. John F. Boere, Andrew J. Lucking

Publikováno v: Mills, N L, Miller, M R, Lucking, A J, Beveridge, J, Flint, L, Boere, A J F, Fokkens, P H, Boon, N A, Sandstrom, T, Blomberg, A, Duffin, R, Donaldson, K, Hadoke, P W F, Cassee, F R & Newby, D E 2011, ' Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation ', European Heart Journal, vol. 32, no. 21, pp. 2660-2671 . https://doi.org/10.1093/eurheartj/ehr195
European Heart Journal

AimExposure to road traffic and air pollution may be a trigger of acute myocardial infarction, but the individual pollutants responsible for this effect have not been established. We assess the role of combustion-derived-nanoparticles in mediating th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730add1768988f4a22afb572f0fbe368
https://doi.org/10.1093/eurheartj/ehr195