Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paul H Quax"'
Autor:
Margreet R de Vries, Anouk Wezel, Erna H Peters, Jacco C Karper, Johan Kuiper, Ilze Bot, Paul H Quax
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Aim: Vein grafts are often used to bypass atherosclerotic lesions; however, patency rates are troublesome due to the development of vein graft disease. Deficiency of toll like receptor (TLR)4, a key initiator of inflammatory signaling, results in red
Autor:
Anouk Wezel, Sabine M Welten, Wida Razawy, H Maxime Lagraauw, Margreet R de Vries, Ekambar R Kandimalla, Johan Kuiper, Paul H Quax, A Yaël Nossent, Ilze Bot
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Introduction: Atherosclerosis is a multifactorial disease involving inflammatory, metabolic and lipid-related processes. As microRNAs (miRs) regulate expression of up to hundreds of target genes, we aimed to identify miRs that target genes involved i
Autor:
Margreet R de Vries, Jacco C Karper, Erna A Peters, Tineke C van der Pouw Kraan, Rob C de Jong, Jaap F Hamming, Paul H Quax, Anton J Horrevoets
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Introduction: Type I interferons (IFN) are implicated in the development of vascular proliferative diseases. Pathway analysis by gene set enrichment analysis of hypercholesterolemic ApoE3*Leiden murine vein grafts revealed that the type I IFN pathway
Autor:
Anouk Wezel, H Maxime Lagraauw, Daniël van der Velden, Saskia C de Jager, Paul H Quax, Johan Kuiper, Ilze Bot
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Rationale: Activated mast cells have been identified in atherosclerotic plaques. As mast cells have the ability to release chemokines that mediate leukocyte fluxes, we propose that activated mast cells play a pivotal role in leukocyte recruitment dur
Autor:
Margreet R de Vries, Rob C de Jong, Erna A Peters, Jaap F Hamming, Marie-José Goumans, Paul H Quax
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Immature plaque neovessels contribute to atherosclerotic plaque instability and intraplaque hemorrhage by leaking erythrocytes and leukocytes in the plaque. Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), together with the angiopoietin (Ang)-
Autor:
Eric P van der Veer, Ruben G de Bruin, Adriaan O Kraaijeveld, Margreet R de Vries, Tonio Pera, Filip M Segers, Stella Trompet, Janine M van Gils, Marko K Roeten, Cora M Beckers, Peter J van Santbrink, Anique Janssen, Coen van Solingen, Jim Swildens, Hetty C de Boer, Ilze Bot, Erna A Peters, Mat Rousch, Merijn Doop, Martin Jan Schalij, Allard C van der Wal, Stehpane Richard, Theo J van Berkel, J. G Pickering, Pieter S Hiemstra, Marie Jose Goumans, Ton J Rabelink, Antoine A de Vries, Paul H Quax, J. W Jukema, Erik A Biessen, Anton Jan van Zonneveld
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33
In response to vascular injury, smooth muscle cells (VSMC) adopt a proliferative, synthetic hypocontractile phenotype. This phenotype switch is deemed instrumental in vascular remodeling in both health and disease. Here, we detail a decisive role for
Autor:
Margreet R de Vries, Leonard Seghers, Imo E Hoefer, Evangelia Pardali, Beerend P Hierck, Peter Ten Dijke, Marie José Goumans, Paul H Quax
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32
Introduction: TGF- β stimulates both shear stress induced arteriogenesis and ischemia induced angiogenesis, by signaling through different receptors. In this study the role of TGF-β receptors ALK1 and endoglin is assessed in a murine model for hind
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32
Introduction Immune cells such as monocytes and T cells but also NK cells are proven contributors to atherosclerosis. Interestingly, C57BL/6 mice display profound induced vascular remodeling in arteriogenesis whereas BALB/c mice show less remodeling.