Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Paul H, Guth"'
Autor:
Izumi Kaji, Toshihiko Iwanaga, Jonathan D. Kaunitz, Eli Engel, Masahiko Watanabe, Paul H. Guth, Yasutada Akiba
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G188-G197
Bacterial or ingested food-derived short-chain fatty acids (SCFAs) are present in the duodenal lumen. Acetate, the most abundant SCFA in the foregut lumen, is absorbed immediately after ingestion, although the mechanism by which this absorption occur
Autor:
Takuya Inoue, Masaaki Higashiyama, Eli Engel, Kazuyuki Narimatsu, Ken-ichi Iwamoto, Izumi Kaji, Paul H. Guth, Masahiko Watanabe, Yasutada Akiba, Atsukazu Kuwahara, Jonathan D. Kaunitz
Publikováno v:
The Journal of Physiology. 593:585-599
Intraduodenal fatty acids (FA) and bacterial overgrowth, which generate short-chain FAs (SCFAs), have been implicated in the generation of functional dyspepsia symptoms. We studied the mechanisms by which luminal SCFA perfusion affects duodenal HCO3
Autor:
Maggie Ham, Joonho Wang, Chikako Watanabe, Jonathan D. Kaunitz, Paul H. Guth, Takanari Nakano, Misa Mizumori, Yasutada Akiba, Takuya Inoue, Eli Engel
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:607-613
Luminal ATP increases duodenal bicarbonate secretion (DBS) via brush border P2Y receptors. Because ATP is sequentially dephosphorylated to adenosine (ADO) and the brush border highly expresses adenosine deaminase (ADA), we hypothesized that luminal [
Publikováno v:
The Journal of Physiology. 587:3651-3663
Regulation of localized extracellular pH (pHo) maintains normal organ function. An alkaline microclimate overlying the duodenal enterocyte brush border protects the mucosa from luminal acid. We hypothesized that intestinal alkaline phosphatase (IAP)
Publikováno v:
Gastrointestinal Endoscopy. 69:546-550
Background Intermittent warm-water infusion in lieu of air insufflation permitted 52% of patients who accepted sedation on demand to complete colonoscopy without sedation. Objective To test the hypothesis that the water method enhances cecal intubati
Autor:
Paul H. Guth, Jonathan D. Kaunitz
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G1109-G1113
The Center for Ulcer Research and Education (CURE) from its onset was primarily the work of one man: Professor Morton Grossman, or “Mort” as he was known and called by all. Mort's legacy includes a large body of scientific publications, the first
Autor:
Paul H, Guth
Publikováno v:
Journal of gastroenterology and hepatology. 30
In 1951, I began a 2-year postdoctoral research fellowship under Dr Simon Komarov at Temple University. Later, as a staff gastroenterologist at the Orange County General Hospital in California, I was interested in the possible role of blood flow alte
Autor:
Jonathan D. Kaunitz, Eli Engel, Tetsu Takeuchi, Misa Mizumori, Claudiu T. Supuran, Paul H. Guth, Shu Lim, Paul W. N. Lee, Justin G. Meyerowitz, Yasutada Akiba
Publikováno v:
The Journal of Physiology. 573:827-842
The duodenum must absorb ∼450 mmol of H+ per 24 h in order to decrease [H+] of the luminal content by 6 log orders over its 15 cm length (Feldman & Colturi, 1984). HCl in the duodenal lumen is neutralized by HCO3− secreted by the pancreas and duo
Autor:
Eli Engel, Jonathan D. Kaunitz, Keishi Kawakubo, Yvette Taché, David W. Adelson, Yasutada Akiba, Paul H. Guth
Publikováno v:
Peptides. 26:1580-1589
RX 77368 (RX) increases gastric mucosal blood flow by a vagal cholinergic mechanism. The relative roles of mucosal and connective tissue mast cells (MMC and CTMC) were investigated in RX-injected rats. Blood flow and mast cell degranulation were meas
Autor:
Eli Engel, Jonathan D. Kaunitz, Paul H. Guth, Lening Zhang, Tetsu Takeuchi, Osamu Furukawa, Luke C. Bi, Yasutada Akiba, Masahiko Hirokawa
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 288:G557-G563
The proximal duodenum is exposed to extreme elevations of Pco2because of the continuous mixture of secreted HCO3−with gastric acid. These elevations (up to 80 kPa) are likely to place the mucosal cells under severe acid stress. Furthermore, we hypo