Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Paul Gregorevic"'
Autor:
Kristy Swiderski, Timur Naim, Jennifer Trieu, Annabel Chee, Marco J. Herold, Andrew J. Kueh, Craig A. Goodman, Paul Gregorevic, Gordon S. Lynch
Publikováno v:
Physiological Reports, Vol 12, Iss 13, Pp n/a-n/a (2024)
Abstract The dystrophin protein has well‐characterized roles in force transmission and maintaining membrane integrity during muscle contraction. Studies have reported decreased expression of dystrophin in atrophying muscles during wasting condition
Externí odkaz:
https://doaj.org/article/e3f8dce52d1343ea87adfed715477910
Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
Autor:
Sheree D. Martin, Timothy Connor, Andrew Sanigorski, Kevin A. McEwen, Darren C. Henstridge, Brunda Nijagal, David De Souza, Dedreia L. Tull, Peter J. Meikle, Greg M. Kowalski, Clinton R. Bruce, Paul Gregorevic, Mark A. Febbraio, Fiona M. Collier, Ken R. Walder, Sean L. McGee
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-13 (2023)
Abstract Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we show that lipotoxicity increased h
Externí odkaz:
https://doaj.org/article/cb089318d6ca4cdc83eb1a778a2e7a37
Autor:
Kristy Swiderski, Audrey S. Chan, Marco J. Herold, Andrew J. Kueh, Jin D. Chung, Justin P. Hardee, Jennifer Trieu, Annabel Chee, Timur Naim, Paul Gregorevic, Gordon S. Lynch
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/0b8d5a9dc15b471b9c11baee9e4ca30c
Autor:
Trang T. Vu, Kyeongmin Kim, Millennium Manna, Justin Thomas, Bryan C. Remaily, Emma J. Montgomery, Travis Costa, Lauren Granchie, Zhiliang Xie, Yizhen Guo, Min Chen, Alyssa Marie M. Castillo, Samuel K. Kulp, Xiaokui Mo, Sridhar Nimmagadda, Paul Gregorevic, Dwight H. Owen, Latha P. Ganesan, Thomas A. Mace, Christopher C. Coss, Mitch A. Phelps
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107048- (2024)
High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, cachexia and ICI therapy failure are unknown
Externí odkaz:
https://doaj.org/article/2e67e650671f4d189b77c2eafc481db4
Autor:
Kate T. Murphy, Kristy Swiderski, James G. Ryall, Jonathan R. Davey, Hongwei Qian, Séverine Lamon, Victoria C. Foletta, Jennifer Trieu, Annabel Chee, Suzannah J. Read, Timur Naim, Paul Gregorevic, Gordon S. Lynch
Publikováno v:
JCSM Rapid Communications, Vol 5, Iss 1, Pp 102-116 (2022)
Abstract Background Cachexia is a debilitating complication of cancer characterized by progressive wasting and weakness of skeletal muscles that reduces quality of life and can compromise survival. Many anticancer treatments, such as chemotherapy, al
Externí odkaz:
https://doaj.org/article/4b80acbe02104dee8ebddccaedd7c9ba
Autor:
Jeffrey Molendijk, Ronnie Blazev, Richard J Mills, Yaan-Kit Ng, Kevin I Watt, Daryn Chau, Paul Gregorevic, Peter J Crouch, James BW Hilton, Leszek Lisowski, Peixiang Zhang, Karen Reue, Aldons J Lusis, James E Hudson, David E James, Marcus M Seldin, Benjamin L Parker
Publikováno v:
eLife, Vol 11 (2022)
Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we performed a proteomic analysis of gastrocnemius muscle from 73 genetically distinct inbred mouse
Externí odkaz:
https://doaj.org/article/76f8d20a7ebb449dbd9f9358e1869662
Autor:
Xiuqing Han, Lisbeth Liliendal Valbjørn Møller, Estelle De Groote, Kirstine Nyvold Bojsen‐Møller, Jonathan Davey, Carlos Henríquez‐Olguin, Zhencheng Li, Jonas Roland Knudsen, Thomas Elbenhardt Jensen, Sten Madsbad, Paul Gregorevic, Erik Arne Richter, Lykke Sylow
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 6, Pp 1241-1257 (2019)
Abstract Background Skeletal muscle wasting is often associated with insulin resistance. A major regulator of muscle mass is the transforming growth factor β (TGF‐β) superfamily, including activin A, which causes atrophy. TGF‐β superfamily lig
Externí odkaz:
https://doaj.org/article/dd8c8c9c3b104cf7b0bbb947b4cf7469
Autor:
Simon T. Bond, Aowen Zhuang, Christine Yang, Eleanor A.M. Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin I. Watt, Yanie Tan, Helen Kiriazis, Graeme I. Lancaster, Paul Gregorevic, Darren C. Henstridge, Julie R. McMullen, Peter J. Meikle, Anna C. Calkin, Brian G. Drew
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101292- (2021)
Objective: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest for the benefit of both research and therapeutic applications. Whilst many advances have, and continue to be made in this
Externí odkaz:
https://doaj.org/article/9b56d5f453674ef7a4d560824691508a
Autor:
Mitchel Tate, Nimna Perera, Darnel Prakoso, Andrew M. Willis, Minh Deo, Osezua Oseghale, Hongwei Qian, Daniel G Donner, Helen Kiriazis, Miles J. De Blasio, Paul Gregorevic, Rebecca H. Ritchie
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Diabetes is a major contributor to the increasing burden of heart failure prevalence globally, at least in part due to a disease process termed diabetic cardiomyopathy. Diabetic cardiomyopathy is characterised by cardiac structural changes that are c
Externí odkaz:
https://doaj.org/article/2b6aa04b548c47ee98472cd4def7dc08
Autor:
Aowen Zhuang, Anna C. Calkin, Shannen Lau, Helen Kiriazis, Daniel G. Donner, Yingying Liu, Simon T. Bond, Sarah C. Moody, Eleanor A.M. Gould, Timothy D. Colgan, Sergio Ruiz Carmona, Michael Inouye, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling, Gregory A. Quaife-Ryan, James E. Hudson, Enzo R. Porrello, Paul Gregorevic, Xiao-Ming Gao, Xiao-Jun Du, Julie R. McMullen, Brian G. Drew
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102537- (2021)
Summary: Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the maintenance and physiological function of various tissues including the heart. The lncRNA OIP5-AS1 (1700020I14
Externí odkaz:
https://doaj.org/article/453eb2947cf84c34a110e74e3feab67a