Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Paul Gontarz"'
Autor:
Xin Huang, Kyoung-mi Park, Paul Gontarz, Bo Zhang, Joshua Pan, Zachary McKenzie, Laura A. Fischer, Chen Dong, Sabine Dietmann, Xiaoyun Xing, Pavel V. Shliaha, Jihong Yang, Dan Li, Junjun Ding, Tenzin Lungjangwa, Maya Mitalipova, Shafqat A. Khan, Sumeth Imsoonthornruksa, Nick Jensen, Ting Wang, Cigall Kadoch, Rudolf Jaenisch, Jianlong Wang, Thorold W. Theunissen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Although the interactors of pluripotency factors have been identified in mouse embryonic stem cells (ESCs), their interactors in human ESCs remain unexplored. Here the authors map OCT4 protein interactions in naïve and primed human ESCs to find spec
Externí odkaz:
https://doaj.org/article/475ca4c998cb484bb6963209f6ebdc13
Autor:
Kesavan Meganathan, Ramachandran Prakasam, Dustin Baldridge, Paul Gontarz, Bo Zhang, Fumihiko Urano, Azad Bonni, Susan E. Maloney, Tychele N. Turner, James E. Huettner, John N. Constantino, Kristen L. Kroll
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-26 (2021)
Abstract Background Copy number variants (CNVs) linked to genes involved in nervous system development or function are often associated with neuropsychiatric disease. While CNVs involving deletions generally cause severe and highly penetrant patient
Externí odkaz:
https://doaj.org/article/28040e7bbee74beeb05f76bab9132942
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-25 (2020)
Abstract Background Transposable elements (TEs) are a significant component of eukaryotic genomes and play essential roles in genome evolution. Mounting evidence indicates that TEs are highly transcribed in early embryo development and contribute to
Externí odkaz:
https://doaj.org/article/bbc3d3e541ae48a3830ea0cc4b12fee1
Autor:
Emily M. A. Lewis, Kesavan Meganathan, Dustin Baldridge, Paul Gontarz, Bo Zhang, Azad Bonni, John N. Constantino, Kristen L. Kroll
Publikováno v:
Molecular Autism, Vol 10, Iss 1, Pp 1-23 (2019)
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with pronounced heritability in the general population. This is largely attributable to the effects of polygenic susceptibility, with inherited liability exhibiting d
Externí odkaz:
https://doaj.org/article/b771a97a74a446ba8807749dd5918580
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
AbstractThe mechanisms that determine the final topology of skeletal muscles remain largely unknown. We have been developing Drosophilaback seat driver, kon-tiki, thisbetumbleweedspalt-majorbarrenpatched
Externí odkaz:
https://doaj.org/article/3a9f2af94d194a8fb001855a8784d301
Autor:
Chen Dong, Mariana Beltcheva, Paul Gontarz, Bo Zhang, Pooja Popli, Laura A Fischer, Shafqat A Khan, Kyoung-mi Park, Eun-Ja Yoon, Xiaoyun Xing, Ramakrishna Kommagani, Ting Wang, Lilianna Solnica-Krezel, Thorold W Theunissen
Publikováno v:
eLife, Vol 9 (2020)
Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell fate decisions during pre-implantation development, but their lineage potential remains incompletely characterized. As naïve hPSCs share transcriptional and e
Externí odkaz:
https://doaj.org/article/675d04b3a8644c879266a76954cb9721
Autor:
Margot L. K. Williams, Atsushi Sawada, Terin Budine, Chunyue Yin, Paul Gontarz, Lilianna Solnica-Krezel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Anteroposterior axis extension during gastrulation is dynamically coordinated, but how this is regulated at a molecular level is unclear. Here, the authors show in zebrafish that the chromatin factor Gon4l, encoded by ugly duckling, coordinates axis
Externí odkaz:
https://doaj.org/article/cd8d2c162cea4451acb9c892aace8007
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
FeatSNP is an online tool and a curated database for exploring 81 million common SNPs’ potential functional impact on the human brain. FeatSNP uses the brain transcriptomes of the human population to improve functional annotation of human SNPs by i
Externí odkaz:
https://doaj.org/article/e149699d81554cea9239db88c765b0d8
Autor:
Grant A. Challen, Paul Gontarz, Katherine Y. King, Won Kyun Koh, Hamza Celik, Emily Haussler, Jiameng Sun, Cates Mallaney, Ostap Kukhar, Elizabeth L. Ostrander, Christine R. Zhang
Clonal hematopoiesis (CH) refers to the age-related expansion of specific clones in the blood system, and manifests from somatic mutations acquired in hematopoietic stem cells (HSCs). Most CH variants occur in the gene DNMT3A, but while DNMT3A-mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b62818a0b0bfebc33d5d27553b7205
https://doi.org/10.1158/2643-3230.c.6550686.v1
https://doi.org/10.1158/2643-3230.c.6550686.v1
Autor:
Grant A. Challen, Paul Gontarz, Katherine Y. King, Won Kyun Koh, Hamza Celik, Emily Haussler, Jiameng Sun, Cates Mallaney, Ostap Kukhar, Elizabeth L. Ostrander, Christine R. Zhang
Supplementary Figure from Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616d2d6c65b956e5273592cf8e0eaa10
https://doi.org/10.1158/2643-3230.22544559.v1
https://doi.org/10.1158/2643-3230.22544559.v1