Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Paul Giblin"'
Autor:
Tarik Khaznadar, Helen Susanne Price, Andy Billinton, Martin E. Swarbrick, David Andrew Stevens, Gerard Martin Paul Giblin, Melanie A. Kay, Anton D. Michel, Nicholas Maughan Clayton, David J. Spalding, Alan Naylor, Alex W. Wilson, Amanda C. Allan, Mark Patrick Healy, Iain P. Chessell, Kristin Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1892-1896
A novel series of EP4 agonists and antagonists have been identified, and then used to validate their potential in the treatment of inflammatory pain. This paper describes these novel ligands and their activity within a number of pre-clinical models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c84be478cf9c9b8df7418e7ae7be9570
https://doi.org/10.1016/j.bmcl.2018.03.091
https://doi.org/10.1016/j.bmcl.2018.03.091
Autor:
Robert J. Watson, David Norton, John Skidmore, Christopher N. Johnson, Gerard Martin Paul Giblin, Jennifer Sweeting, Rivers Dean Andrew, Mahmood Ahmed, Andrea C. Haynes, Ian D. Wall, Sally Redshaw, Karen Louise Philpott, Jason Witherington, David N. Hurst, Umesh Kumar, James Myatt, Simon Taylor, Emmanuel Hubert Demont, Alexander J. Stevens, Tom D. Heightman, Rino A. Bit, D. Vesey, Jag Paul Heer, Andrew Peter Cridland
Publikováno v:
Journal of Medicinal Chemistry. 57:10424-10442
The efficacy of the recently approved drug fingolimod (FTY720) in multiple sclerosis patients results from the action of its phosphate metabolite on sphingosine-1-phosphate S1P1 receptors, while a variety of side effects have been ascribed to its S1P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294463cbddaca24a430719ebce700fab
https://doi.org/10.1021/jm5010336
https://doi.org/10.1021/jm5010336
Autor:
Paul Giblin
Publikováno v:
Journal of Spirituality in Mental Health. 16:74-88
Society as a whole, particularly men, is sorely in need of an integrated vision of sexuality and spirituality. In the absence of such a vision, men experience their sexuality as burden not blessing, as nonrelational sexuality, and unconnected lust. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a710d7299958e0096860a5772627a87
https://doi.org/10.1080/19349637.2014.896852
https://doi.org/10.1080/19349637.2014.896852
Autor:
Paul Giblin
Publikováno v:
Journal of Health Care Chaplaincy. 19:112-119
This article is a pastoral counselor's response to a lengthy and unique, theory-driven, chaplain–Parkinson's patient relationship. The author reviews elements of clinical theory, in general, and Narrative Theory, in particular. The chaplain's use o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d1573de4e275c59efa4016fd6760d29
https://doi.org/10.1080/08854726.2013.806120
https://doi.org/10.1080/08854726.2013.806120
Autor:
Paul Giblin
Publikováno v:
The American Journal of Family Therapy. 39:124-138
This article addresses the clinical encounter of men struggling to make and keep marital commitments. The “Male Code” limits mens' feeling and body awareness, thus leaving them information-deprived when it comes to making important decisions. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a34dd14e93eab281cc0d83b119c524
https://doi.org/10.1080/01926187.2010.530173
https://doi.org/10.1080/01926187.2010.530173
Autor:
Gerard Martin Paul Giblin, Beverley Smith, Alan Naylor, James R. Musgrave, Adrian Hall, Rosemary Z. Sasse, Ishrut Hussain, Richard L. Elliott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1306-1311
This Letter details the SAR of a novel series of piperidine-derived gamma-secretase modulators. Compound 10h was found to be a potent modulator in vitro, which on further profiling, was found to decrease Abeta42, increase Abeta38 and have no effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbec3026fbe81a0c341a3b229f3f47c
https://doi.org/10.1016/j.bmcl.2009.08.072
https://doi.org/10.1016/j.bmcl.2009.08.072
Autor:
Gerard Martin Paul Giblin, Paul Goldsmith, Andrew John Eatherton, William L. Mitchell, Brian Peter Slingsby, Andrew Billinton, Alan Naylor, Alex W. Wilson, Andrew J. Brown, Carl Haslam, Matthew R. Johnson, Iain P. Chessell, Alcide Perboni, Michael A. Briggs, Nick M. Clayton
Publikováno v:
Journal of Medicinal Chemistry. 52:5785-5788
We report the synthesis and SAR of a series of novel azaindole CB(2) agonists. 6-Azaindole 18 showed activity in an acute pain model but was inactive in a chronic model. 18 is a Pgp substrate with low brain penetration. The template was redesigned, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d31fdf1a41880ef864d92a59ab1d7e8
https://doi.org/10.1021/jm9009857
https://doi.org/10.1021/jm9009857
Autor:
Adrian Hall, Tiziana Scoccitti, Christopher Budd, Alan Naylor, D. Anthony Rawlings, David N. Hurst, Alex W. Wilson, Nicholas Maughan Clayton, Thomas George Christopher Hayhow, Susan H. Brown, Wendy J. Winchester, Gerard Martin Paul Giblin, Paul Goldsmith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:497-501
Herein we describe the medicinal chemistry programme to identify a potential back-up compound to the EP1 receptor antagonist GW848687X. This work started with the lipophilic 1,2-biaryl benzene derivative 4 which displayed molecular weight of 414.9 g/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d247aa411a40ee1876a94dc9d1a8657f
https://doi.org/10.1016/j.bmcl.2008.11.032
https://doi.org/10.1016/j.bmcl.2008.11.032